A5088320688- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Schizophrenia research and treatment
- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Mental Health Research Topics
- Epilepsy research and treatment
- Bipolar Disorder and Treatment
- Neurological disorders and treatments
- Psychosomatic Disorders and Their Treatments
- Neurotransmitter Receptor Influence on Behavior
- Obsessive-Compulsive Spectrum Disorders
- Electroconvulsive Therapy Studies
- Psychedelics and Drug Studies
- Metabolomics and Mass Spectrometry Studies
- Diet and metabolism studies
- Tryptophan and brain disorders
- Autism Spectrum Disorder Research
- Global Health Workforce Issues
- Cannabis and Cannabinoid Research
- Traumatic Brain Injury Research
- Fetal and Pediatric Neurological Disorders
- Attention Deficit Hyperactivity Disorder
- EEG and Brain-Computer Interfaces
University of Alabama at Birmingham
2016-2025
The Ohio State University
2023-2025
Walter Reed National Military Medical Center
2025
Emory University
2021-2025
Neurobehavioral Systems
2025
VA Palo Alto Health Care System
2021-2025
Stanford University
2021-2025
Uniformed Services University of the Health Sciences
2025
University of Minnesota
2021-2025
Yale University
2025
Data on COVID-19 supports targeted social distancing could be an effective way to reduce morbidity and mortality, but inadvertently increase stigma for affected populations. As health care providers we must aware of the facts COVID-19, cultural implications, potential stigmatization populations by COVID-2019. It is important consider real economic impact related lost workdays due quarantine isolation efforts as well travel restrictions that may negatively access ability pay care. Efforts...
Since Emil Kraepelin's conceptualization of endogenous psychoses as dementia praecox and manic depression, the separation between primary psychotic disorders affective has been much debated. We conducted a systematic review case-control studies contrasting magnetic resonance imaging in schizophrenia bipolar disorder. A literature search PubMed published January 2005 December 2016 was conducted, 50 structural, 29 functional, 7 spectroscopy, 8 combined genetic were deemed eligible for review....
Alterations in glutamatergic neurotransmission have been postulated to be a key pathophysiologic mechanism schizophrenia.To evaluate hippocampal volumetric measures and neurometabolites unmedicated patients with schizophrenia the correlations between these markers. Our priori hypothesis was that glutamate levels would negatively correlate volume schizophrenia.Combined 3-T structural magnetic resonance imaging single-voxel proton spectroscopy study at Department of Psychiatry Behavioral...
To better characterize hippocampal pathophysiology in schizophrenia, we conducted a longitudinal study evaluating functional connectivity during resting state, using seeds prescribed its anterior and posterior regions. We enrolled 34 unmedicated patients with schizophrenia or schizoaffective disorder (SZ) matched healthy controls. SZ were scanned while off medication, then treated risperidone for 6 weeks re-scanned ( n = 22). Group differences connectivity, as well changes over time,...
A number of neuroimaging studies have provided evidence in support the hypothesis that faulty interactions between spatially disparate brain regions underlie pathophysiology schizophrenia, but it remains unclear to what degree antipsychotic medications affect these. We hypothesized balance functional integration and segregation networks is impaired unmedicated patients with can be partially restored by medications. included 32 schizophrenia (SZ) matched healthy controls (HC) this study....
To describe abnormalities in large scale functional networks unmedicated patients with schizophrenia and to examine effects of risperidone on networks.34 34 matched healthy controls were enrolled this longitudinal study. We collected resting state MRI data a 3T scanner at baseline six weeks after they started risperidone. In addition, group 19 scanned twice apart. Four networks, the dorsal attention network, executive control salience default mode network identified seed based connectivity...
Proton magnetic resonance spectroscopy (1H-MRS) allows the non-invasive measurement of several metabolites, including N-acetyl-aspartate (NAA), an amino acid exclusively synthesized in mitochondria neurons, and glutamate, involved excitatory neurotransmission metabolism. In view recent postmortem studies schizophrenia (SZ) revealing mitochondrial abnormalities as well perturbed expression enzymes regulating glutamate–glutamine cycle, we hypothesized that a disruption homeostasis NAA...
Evidence points toward a relationship between longer duration of untreated psychosis (DUP) and worse long-term outcomes in patients with first episode (FEP), but the underlying neurobiology remains poorly understood. Proton magnetic resonance spectroscopy studies have reported altered hippocampus glutamatergic neurotransmission, structural MRI as hippocampal atrophy that may be associated memory impairment schizophrenia. Here, we quantify left glutamate (Glx) subfield volumes 54...
Schizophrenia is often characterized by dysconnections in the brain, which can be estimated via functional connectivity analyses. Commonly measured using resting-state magnetic resonance imaging (fMRI) order to characterize intrinsic or baseline function of fMRI has significantly contributed understanding schizophrenia. However, these measures may not capture full extent abnormalities schizophrenia as temporally limited hemodynamic response. In extend findings, complementary modality...