A5082633371- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Blood Pressure and Hypertension Studies
- Potassium and Related Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Functional Brain Connectivity Studies
- Mechanical Circulatory Support Devices
- Cardiac Arrest and Resuscitation
- Multiple Sclerosis Research Studies
- Schizophrenia research and treatment
- Cardiac pacing and defibrillation studies
- Geriatric Care and Nursing Homes
- Emergency and Acute Care Studies
- Cardiac electrophysiology and arrhythmias
- Advanced Neuroimaging Techniques and Applications
- Chronic Disease Management Strategies
- Prostate Cancer Treatment and Research
- Cardiovascular Health and Risk Factors
- Anesthesia and Pain Management
- Advanced MRI Techniques and Applications
- Epilepsy research and treatment
- Meta-analysis and systematic reviews
- Hormonal Regulation and Hypertension
- Pharmaceutical Practices and Patient Outcomes
- Statistical Methods in Clinical Trials
University of Alabama at Birmingham
2016-2025
Tufts University
2025
Veterans Health Administration
2014-2024
London North West Healthcare NHS Trust
2024
North East London NHS Foundation Trust
2019
Georgetown University
2015-2018
Washington Hospital
2016-2018
George Washington University
2015-2018
Cancer Research And Biostatistics
2018
Washington University Medical Center
2017
Elucidating virus-host interactions responsible for HIV-1 transmission is important advancing prevention strategies. To this end, single genome amplification (SGA) and sequencing of within the context a model random virus evolution has made possible first time an unambiguous identification transmitted/founder viruses precise estimation their numbers. Here, we applied approach to env analyses in cohort acutely infected men who have sex with (MSM) found that high proportion (10 28; 36%) had...
The distant organs to which breast cancer preferentially metastasizes are of significant clinical importance.We explored the relationship between clinicopathologic factors and common sites metastasis in 531 consecutive patients with advanced cancer.Breast subtype as a variable was significantly associated all five relapse by multivariate analysis. luminal tumors were remarkable for their bone-seeking phenotype less frequently observed lung, brain, pleural metastases likely be multiorgan...
Recent studies indicate that sexual transmission of human immunodeficiency virus type 1 (HIV-1) generally results from productive infection by only one virus, a finding attributable to the mucosal barrier. Surprisingly, recent study injection drug users (IDUs) St. Petersburg, Russia, also found most subjects be acutely infected single virus. Here, we show single-genome amplification and sequencing in different IDU cohort 60% were more than including subject who was at least 16 viruses....
Background— Inotrope use in heart failure treatment was associated with improved symptoms, but worse survival clinical trials. However, these studies predated of modern therapies. This study evaluates contemporary outcomes on long-term inotropes. Methods and Results— We collected baseline postinotrope data 197 patients discharged inotropes between January 2007 March 2013. Baseline characteristics, hemodynamic changes inotropes, were evaluated. Patients initiated had refractory failure,...
To determine whether early coagulopathy affects the mortality associated with severe civilian pediatric trauma, trauma patients younger than 18 years admitted to a intensive care unit from 2001 2010 were evaluated. Patients burns, primary asphyxiation, preexisting bleeding diathesis, lack of coagulation studies, or transferred other hospitals more 24 h after injury excluded. Age, sex, race, mechanism injury, initial systolic blood pressure, Glasgow Coma Scale score, Injury Severity Score,...
Lower systolic blood pressure (SBP) levels are associated with poor outcomes in patients heart failure. Less is known about this association failure preserved ejection fraction (HFpEF).
Background and objectives Quadratus lumborum (QL) block is a new regional analgesic technique for upper lower abdominal surgeries as part of multimodal regime. It has also been reported to relieve pain after total hip arthroplasty (THA). In this prospective, randomized, double-blind study, we compared QL with control (no block) in patients undergoing primary THA. Methods Eighty THA surgery under spinal anesthesia were randomized into two groups, one without block. The both groups sedation,...
The pericapsular nerve group (PENG) block is a novel regional anaesthesia technique that has been proposed as an effective motor-sparing for total hip arthroplasty. Recent randomised studies show conflicting results regarding the analgesic efficacy of PENG arthroplasty.We conducted controlled observer-blinded single-centre superiority trial comparing with no patients undergoing primary arthroplasty under spinal anaesthesia. All subjects received multimodal analgesia consisting paracetamol...
Zero-inflated Poisson (ZIP) and zero-inflated negative binomial (ZINB) models are recommended for handling excessive zeros in count data. For various reasons, researchers may not address zero inflation. This paper helps educate on (1) the importance of accounting inflation (2) consequences misspecifying statistical model. Using simulations, we found that when data was ignored, estimation poor statistically significant findings were missed. When overdispersion within inflated Type I errors...
Background— According to the 2004 Surgeon General’s Report on Health Consequences of Smoking, after >15 years abstinence, cardiovascular risk former smokers becomes similar that never-smokers. Whether this health benefit smoking cessation varies by amount and duration prior remains unclear. Methods Results— Of 4482 adults ≥65 without prevalent heart failure (HF) in Cardiovascular Study, 2556 were never-smokers, 629 current smokers, 1297 with cessation, whom 312 heavy (highest quartile;...
Background Black individuals are at greater risk of stroke and vitamin D deficiency than white individuals. Epidemiologic studies have shown that low 25-hydroxyvitamin concentrations associated with increased stroke, but these had limited representation black Methods We examined the association incident in Reasons for Geographic Racial Differences Stroke (REGARDS) study, a cohort adults ≥45 years age. Using case–cohort study design, plasma was measured 610 participants who developed (cases)...
Background Trauma is the leading cause of death and disability in patients aged 1–46 y. Severely injured experience considerable blood loss hemorrhagic shock requiring treatment with massive transfusion red cells (RBCs). Preclinical retrospective human studies trauma have suggested that poorer therapeutic efficacy, increased severity organ injury, bacterial infection are associated large volumes stored RBCs, although mechanisms not fully understood. Methods findings We developed a murine...