A5052037843- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Schizophrenia research and treatment
- Metabolomics and Mass Spectrometry Studies
- Memory and Neural Mechanisms
- Cannabis and Cannabinoid Research
- Neural and Behavioral Psychology Studies
- Advanced NMR Techniques and Applications
- Neural dynamics and brain function
- Diet and metabolism studies
- Medical Imaging Techniques and Applications
- Atomic and Subatomic Physics Research
- Psychedelics and Drug Studies
- Neurotransmitter Receptor Influence on Behavior
- Biochemical Analysis and Sensing Techniques
- Medicinal Plants and Neuroprotection
- Fetal and Pediatric Neurological Disorders
- Pain Management and Placebo Effect
- Spatial Cognition and Navigation
- Amino Acid Enzymes and Metabolism
- Neurological and metabolic disorders
- Eicosanoids and Hypertension Pharmacology
- Sleep and related disorders
Auburn University
2015-2024
Advanced Imaging Research (United States)
2018-2024
University of Alabama at Birmingham
2010-2021
Albert Einstein College of Medicine
2002
Montefiore Medical Center
2002
SLC7A11, the catalytic subunit of cystine/glutamate antiporter, System x c − (SXC), is up-regulated in a subpopulation patient gliomas, where it responsible for excitotoxic glutamate release, accelerated tumor growth, and tumor-associated seizures.
Alterations in glutamatergic neurotransmission have been postulated to be a key pathophysiologic mechanism schizophrenia.To evaluate hippocampal volumetric measures and neurometabolites unmedicated patients with schizophrenia the correlations between these markers. Our priori hypothesis was that glutamate levels would negatively correlate volume schizophrenia.Combined 3-T structural magnetic resonance imaging single-voxel proton spectroscopy study at Department of Psychiatry Behavioral...
Recent magnetic resonance spectroscopy (MRS) studies suggest that abnormalities of the glutamatergic system in schizophrenia may be dependent on illness stage, medication status, and symptomatology. Glutamatergic metabolites appear to elevated prodromal early stages but unchanged or reduced below normal chronic, medicated patients. However, few these have measured with high-field 7T MR scanners, which offer higher signal-to-noise ratio better spectral resolution than 3T scanners facilitate...
Proton magnetic resonance spectroscopy (1H-MRS) allows the non-invasive measurement of several metabolites, including N-acetyl-aspartate (NAA), an amino acid exclusively synthesized in mitochondria neurons, and glutamate, involved excitatory neurotransmission metabolism. In view recent postmortem studies schizophrenia (SZ) revealing mitochondrial abnormalities as well perturbed expression enzymes regulating glutamate–glutamine cycle, we hypothesized that a disruption homeostasis NAA...
Impairment in episodic memory is one of the most robust findings schizophrenia. Disruptions fronto-temporal functional connectivity that could explain some aspects these deficits have been reported. Recent work has identified abnormal hippocampal function unmedicated patients with schizophrenia (SZ), such as increased metabolism and glutamate content are not always seen medicated SZ. For reasons, we hypothesized altered might originate from hippocampus be partially restored by antipsychotic...
Schizophrenia is often characterized by dysconnections in the brain, which can be estimated via functional connectivity analyses. Commonly measured using resting-state magnetic resonance imaging (fMRI) order to characterize intrinsic or baseline function of fMRI has significantly contributed understanding schizophrenia. However, these measures may not capture full extent abnormalities schizophrenia as temporally limited hemodynamic response. In extend findings, complementary modality...
ABSTRACT Abnormalities in resting state connectivity schizophrenia (SZ) are now well established, but the biological substrates of these functional alterations remain to be elucidated. We performed a combined magnetic resonance imaging and spectroscopy study 22 unmedicated patients with SZ matched healthy controls (HCs) evaluate hippocampus Glx/Cr (a glutamate + glutamine peak normalized creatine) investigate neurometabolic abnormalities examine relationship between these. Functional left...
Schizophrenia (SZ) is associated with a reduced ability to set meaningful goals reach desired outcomes. The delay-discounting (DD) task, in which one chooses between sooner smaller and later larger rewards, has proven useful revealing executive function reward deficits various clinical groups. We used fMRI patients SZ healthy controls (HC) compare brain activation during performance of DD task. Prior the neuroimaging session, we obtained each participant's rate DD, k, on task it select...
Previous studies have observed impairments in both brain function and neurometabolite levels schizophrenia. In this study, we investigated the relationship between activity neurochemistry unmedicated patients with schizophrenia if is altered following antipsychotic medication by combining proton magnetic resonance spectroscopy (1H-MRS) functional imaging (fMRI). We used single voxel MRS acquired bilateral dorsal anterior cingulate cortex (ACC) fMRI during performance of a Stroop color-naming...
To understand the mechanism of cognitive control dysfunction in schizophrenia, it is critical to characterize brain function without confounding effect medication. It also important establish extent which antipsychotic medication restores and whether those changes are related psychosis improvement. Twenty-two patients with initially unmedicated after a 6-week course risperidone, 20 healthy controls (HC) studied twice, 6 weeks apart, performed an fMRI task. We examined group longitudinal...
Abstract Background: Because dopamine neurons signal a mismatch between expected and actual reward called prediction error (PE), aberrant PE signals in schizophrenia have been attributed to known dopaminergic abnormalities. However, dysfunction of N -methyl-D-aspartate receptors on cortical γ-aminobutyric acid neurons, as hypothesized schizophrenia, could lead excess glutamate release the substantia nigra (SN) affect processing. Aims: The aim this study was investigate contribution SN...
Abstract Acquisition of multimodal brain imaging data for the same subject has become more common leading to a growing interest in determining intermodal relationships between modalities further elucidate pathophysiology schizophrenia. Multimodal have previously been individually analyzed and subsequently integrated; however, these analysis techniques lack ability examine true modality inter‐relationships. The utilization multiset canonical correlation joint independent component (mCCA +...