A5013246959- Treatment of Major Depression
- Mental Health Research Topics
- Bipolar Disorder and Treatment
- Schizophrenia research and treatment
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Tryptophan and brain disorders
- Child and Adolescent Psychosocial and Emotional Development
- Mental Health Treatment and Access
- Electroconvulsive Therapy Studies
- Functional Brain Connectivity Studies
- Stress Responses and Cortisol
- Health Systems, Economic Evaluations, Quality of Life
- Sleep and Wakefulness Research
- Sleep and related disorders
- Attention Deficit Hyperactivity Disorder
- Maternal Mental Health During Pregnancy and Postpartum
- Vagus Nerve Stimulation Research
- Advanced Proteomics Techniques and Applications
- Neurological disorders and treatments
- Suicide and Self-Harm Studies
- Mental Health and Psychiatry
- Psychotherapy Techniques and Applications
- Cardiac Health and Mental Health
- Obsessive-Compulsive Spectrum Disorders
- Neurotransmitter Receptor Influence on Behavior
National University of Singapore
2016-2025
Duke University
2015-2025
Duke-NUS Medical School
2014-2024
GGZ inGeest
2023-2024
Vrije Universiteit Amsterdam
2023-2024
Amsterdam University Medical Centers
2023-2024
Helmholtz Zentrum München
2023-2024
Arkansas State University
2024
Emory University
2002-2024
University of South Carolina
2024
ContextUncertainties exist about prevalence and correlates of major depressive disorder (MDD).ObjectiveTo present nationally representative data on MDD by Diagnostic Statistical Manual Mental Disorders, Fourth Edition (DSM-IV) criteria, study patterns treatment adequacy from the recently completed National Comorbidity Survey Replication (NCS-R).DesignFace-to-face household survey conducted February 2001 to December 2002.SettingThe 48 contiguous United States.ParticipantsHousehold residents...
Objective: This report describes the participants and compares acute longer-term treatment outcomes associated with each of four successive steps in Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial. Method: A broadly representative adult outpatient sample nonpsychotic major depressive disorder received one (N=3,671) (N=123) steps. Those not achieving remission or unable tolerate a step were encouraged move next step. an acceptable benefit, preferably symptom remission,...
Selective serotonin reuptake inhibitors (SSRIs) are widely used to treat depression, but the rates, timing, and baseline predictors of remission in "real world" patients not established. The authors' primary objectives this study were evaluate effectiveness citalopram, an SSRI, using measurement-based care actual practice, identify symptom outpatients with major depressive disorder.This clinical included disorder who treated 23 psychiatric 18 settings. received flexible doses citalopram...
Synopsis The psychometric properties of the 28- and 30-item versions Inventory Depressive Symptomatology, Clinician-Rated (IDS-C) Self-Report (IDS-SR) are reported in a total 434 (28-item) 337 (30-item) adult out-patients with current major depressive disorder 118 euthymic subjects (15 remitted depressed 103 normal controls). Cronbach's α ranged from 0·92 to 0·94 for sample 0·76 0·82 those depression. Item correlations, as well several tests concurrent discriminant validity reported. Factor...
A need exists for technologies that permit the direct quantification of differences in protein and posttranslationally modified expression levels. Here we present a strategy absolute (termed AQUA) proteins their modification states. Peptides are synthesized with incorporated stable isotopes as ideal internal standards to mimic native peptides formed by proteolysis. These synthetic can also be prepared covalent modifications (e.g., phosphorylation, methylation, acetylation, etc.) chemically...
Patients with chronic forms of major depression are difficult to treat, and the relative efficacy medications psychotherapy is uncertain.
After unsuccessful treatment for depression with a selective serotonin-reuptake inhibitor (SSRI), it is not known whether switching to one antidepressant more effective than another.We randomly assigned 727 adult outpatients nonpsychotic major depressive disorder who had no remission of symptoms or could tolerate the SSRI citalopram receive following drugs up 14 weeks: sustained-release bupropion (239 patients) at maximal daily dose 400 mg, sertraline (238 200 extended-release venlafaxine...
<h3>Background:</h3> Depression is a major cause of morbidity and mortality in children adolescents. To date, randomized, controlled, double-blind trials antidepressants (largely tricyclic agents) have yet to reveal that any antidepressant more effective than placebo. This article double-blind, placebo-controlled trial fluoxetine adolescents with depression. <h3>Method:</h3> Ninety-six child adolescent outpatients (aged 7-17 years) nonpsychotic depressive disorder were randomized (stratified...
Although clinicians frequently add a second medication to an initial, ineffective antidepressant drug, no randomized controlled trial has compared the efficacy of this approach.
Background. The present study provides additional data on the psychometric properties of 30-item Inventory Depressive Symptomatology (IDS) and recently developed Quick (QIDS), a brief 16-item symptom severity rating scale that was derived from longer form. Both IDS QIDS are available in matched clinician-rated (IDS-C 30 ; QIDS-C 16 ) self-report (IDS-SR QIDS-SR formats. Method. patient samples included 544 out-patients with major depressive disorder (MDD) 402 bipolar (BD) drawn 19 regionally...
About half of outpatients with major depressive disorder also have clinically meaningful levels anxiety. The authors conducted a secondary data analysis to compare antidepressant treatment outcomes for patients anxious and nonanxious depression in Levels 1 2 the STAR*D study.A total 2,876 adult disorder, enrolled from 18 primary 23 psychiatric care sites, received citalopram Level STAR*D. In 2, 1,292 who did not remit or tolerate were randomly assigned either switch sustained-release...
Objective: This report describes the participants and compares acute longer-term treatment outcomes associated with each of four successive steps in Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial. Method: A broadly representative adult outpatient sample nonpsychotic major depressive disorder received one (N=3,671) (N=123) steps. Those not achieving remission or unable tolerate a step were encouraged move next step. an acceptable benefit, preferably symptom remission,...
Major depressive disorder is associated with considerable morbidity, disability, and risk for suicide. Treatments depression most commonly include antidepressants, psychotherapy, or the combination. Little known about predictors of treatment response depression. In this study, 681 patients chronic forms major were treated an antidepressant (nefazodone), Cognitive Behavioral Analysis System Psychotherapy (CBASP), Overall, effects alone psychotherapy equal significantly less effective than...