A5005661088- Treatment of Major Depression
- Mental Health Research Topics
- Bipolar Disorder and Treatment
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Schizophrenia research and treatment
- Functional Brain Connectivity Studies
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Child and Adolescent Psychosocial and Emotional Development
- Mental Health Treatment and Access
- Attention Deficit Hyperactivity Disorder
- Suicide and Self-Harm Studies
- Electroconvulsive Therapy Studies
- Cardiac Health and Mental Health
- Substance Abuse Treatment and Outcomes
- Neurotransmitter Receptor Influence on Behavior
- Opioid Use Disorder Treatment
- Advanced MRI Techniques and Applications
- Digital Mental Health Interventions
- Vascular Procedures and Complications
- Eating Disorders and Behaviors
- Advanced Neuroimaging Techniques and Applications
- Maternal Mental Health During Pregnancy and Postpartum
- Physical Activity and Health
- Aortic aneurysm repair treatments
The University of Texas Southwestern Medical Center
2016-2025
Mayo Clinic Health System
2022-2025
Southwestern Medical Center
2011-2023
BP (Canada)
2023
Columbia College - Missouri
2023
Flagstaff Medical Center
2023
WinnMed
2022
Mayo Clinic
2022
Mayo Clinic in Florida
2022
Cleveland Clinic
2022
The use of naltrexone plus bupropion to treat methamphetamine disorder has not been well studied. We conducted this multisite, double-blind, two-stage, placebo-controlled trial with the a sequential parallel comparison design evaluate efficacy and safety extended-release injectable (380 mg every 3 weeks) oral (450 per day) in adults moderate or severe disorder. In first stage trial, participants were randomly assigned 0.26:0.74 ratio receive naltrexone-bupropion matching placebo for 6 weeks....
Abstract This paper describes the rationale and methods entailed in developing Inventory of Depressive Symptomatology (IDS) both clinician‐rated (IDS‐C) self‐reported (IDS‐SR) formats. Psychometric features IDS‐C IDS‐SR are presented. These scales compared to Hamilton Rating Scale for Depression (HRS‐D) detection symptom change patients with major depressive (n = 184) or bipolar disorder 141). The face validity established psychometric indicate that either may be useful detecting change, as...
Postpartum depressive disorders lead to maternal disability and disturbed mother-infant relationships, but information regarding the rates of major disorder in minority women is noticeably lacking. The goal this study was determine whether risk factors for rate postpartum a predominantly African American Hispanic clinic population would be similar those reported Caucasian women.Investigators systematically screened all scheduled their first visit on selected days at four publicly funded...
<h3>Context</h3> The Texas Medication Algorithm Project is an evaluation of algorithm-based disease management program for the treatment self-declared persistently and seriously mentally ill in public mental health sector. <h3>Objective</h3> To present clinical outcomes patients with major depressive disorder (MDD) during 12-month algorithm-guided (ALGO) compared as usual (TAU). <h3>Design</h3> Effectiveness, intent-to-treat, prospective trial comparing patient clinics offering ALGO matched...
The purpose of this study was to determine whether adjunctive use a psychostimulant (mixed amphetamine salts) safe and efficacious for treatment symptoms attention deficit hyperactivity disorder (ADHD) in pediatric outpatients with bipolar I or II concurrent ADHD whose manic had been stabilized through divalproex sodium.An 8-week open-label trial sodium control discern the effect on followed by 4-week randomized, double-blind, placebo-controlled crossover if mixed salts effective symptoms....
Article Abstract Objective: Most patients with major depressive disorder (MDD) require second-step treatments to achieve remission. The TReatment Exercise Augmentation for Depression (TREAD) study was designed test the efficacy of aerobic exercise as an augmentation treatment MDD who had not remitted antidepressant treatment. Method: Eligible participants in this randomized controlled trial were sedentary individuals (men and women aged 18-70 years) diagnosed DSM-IV nonpsychotic selective...
Objective: Case series and follow-up studies suggest that clozapine may have mood-stabilizing properties in addition to antipsychotic action patients with schizoaffective disorder, bipolar type, I but the generalizability of these findings is limited. This article describes a randomized, open study add-on therapy versus treatment as usual for treatment-resistant illness history mania. Method: Thirty-eight meeting DSM-IV criteria or disorder was deemed were randomly assigned (N=19) (no...
The authors compared fluoxetine and placebo in continuation treatment to prevent relapse of major depressive disorder children adolescents.After a detailed evaluation, adolescents 7-18 years age with were treated openly fluoxetine. Those who had an adequate response after 12 weeks, as indicated by Clinical Global Impression improvement score 1 or 2 decrease at least 50% Children's Depression Rating Scale-Revised score, randomly assigned receive for additional 6 months. primary outcome...
Abstract In the last decade, many studies have used automated processes to analyze magnetic resonance imaging (MRI) data such as cortical thickness, which is one indicator of neuronal health. Due convenience image processing software (e.g., FreeSurfer), standard practice rely on results without performing visual inspection intermediate processing. this work, structural MRIs 40 healthy controls who were scanned twice determine test–retest reliability FreeSurfer‐derived measures in four groups...
Major depressive disorder (MDD) remains challenging to treat. Although several clinical and demographic variables have been found predict poor antidepressant response, these markers not robustly replicated warrant implementation in care. Increased pretreatment rostral anterior cingulate cortex (rACC) theta activity has linked better outcomes. However, no prior study evaluated whether this marker incremental predictive validity over measures.To determine increased rACC would symptom...
Major depressive disorder (MDD) is prevalent among patients with chronic kidney disease (CKD) and associated morbidity mortality. The efficacy adverse events of selective serotonin reuptake inhibitors in these are unknown.To determine whether treatment sertraline improves symptoms CKD MDD.The Chronic Kidney Disease Antidepressant Sertraline Trial (CAST) was a randomized, double-blind, placebo-controlled trial involving 201 stage 3, 4, or 5 non-dialysis-dependent CKD, who were enrolled at 3...
Objective: Major depressive disorder is associated with aberrant resting-state functional connectivity across multiple brain networks supporting emotion processing, executive function, and reward processing. The purpose of this study was to determine whether patterns between regions predict differential outcome antidepressant medication (sertraline) compared placebo. Methods: Participants in the Establishing Moderators Biosignatures Antidepressant Response Clinical Care (EMBARC) underwent...
Objective: Anhedonia, disrupted reward processing, is a core symptom of major depressive disorder. Recent findings demonstrate altered reward-related ventral striatal reactivity in depressed individuals, but the extent to which this specific anhedonia remains poorly understood. The authors examined effect on expectancy (expected outcome value) and prediction error- (discrepancy between expected actual outcome) related reactivity, as well relationship these measures. Method: A total 148...
Abstract Further research is needed to help improve both the standard of care and outcome for patients with treatment-resistant depression. A particularly critical evidence gap exists respect whether pharmacological or non-pharmacological augmentation superior antidepressant switch, vice-versa. The objective this study was compare effectiveness aripiprazole repetitive transcranial magnetic stimulation versus switching venlafaxine XR (or duloxetine those not eligible receive venlafaxine) In...
Corticosteroids, such as prednisone and dexamethasone, are frequently prescribed medications sometimes associated with severe systemic side effects. Currently there limited data regarding the psychiatric effects of these medications, although mood changes even psychoses have been reported. This study was designed to quantify during brief courses in patients asthma. Outpatients asthma (N = 32) receiving bursts (>40 mg/day) were evaluated before, during, after corticosteroid therapy by use...
This study evaluated the validity of prescriber, patient, and research assistant ratings adherence to prescribed oral antipsychotic medication among outpatients with schizophrenia or schizoaffective disorder in comparison electronic monitoring.Adult (N=35) (N=26) received assessments via electronically monitored vial caps as well by monthly report for up six months.Electronic monitoring detected greater nonadherence rates (57%) than either prescribers (7%) patients (5%), though were 54%. No...