Randy L. Buckner
A5048946975- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Neural dynamics and brain function
- Memory and Neural Mechanisms
- Advanced MRI Techniques and Applications
- Neural and Behavioral Psychology Studies
- Memory Processes and Influences
- Dementia and Cognitive Impairment Research
- Genetic Associations and Epidemiology
- Neurobiology of Language and Bilingualism
- Genomic variations and chromosomal abnormalities
- Mental Health Research Topics
- Alzheimer's disease research and treatments
- Health, Environment, Cognitive Aging
- Genetics and Neurodevelopmental Disorders
- Visual perception and processing mechanisms
- Face Recognition and Perception
- Congenital heart defects research
- Bioinformatics and Genomic Networks
- Vestibular and auditory disorders
- EEG and Brain-Computer Interfaces
- Medical Imaging Techniques and Applications
- Epigenetics and DNA Methylation
- Schizophrenia research and treatment
- Hemispheric Asymmetry in Neuroscience
Harvard University
2016-2025
Athinoula A. Martinos Center for Biomedical Imaging
2016-2025
Massachusetts General Hospital
2016-2025
Harvard University Press
2015-2025
Center for Pain and the Brain
2012-2025
Western University
2024
Alzheimer’s Disease Neuroimaging Initiative
2023
Broad Institute
2016-2021
Simons Foundation
2021
Stanley Foundation
2019
Information processing in the cerebral cortex involves interactions among distributed areas. Anatomical connectivity suggests that certain areas form local hierarchical relations such as within visual system. Other patterns, particularly association areas, suggest presence of large-scale circuits without clear relations. In this study organization networks human cerebrum was explored using resting-state functional MRI. Data from 1,000 subjects were registered surface-based alignment. A...
The striatum is connected to the cerebral cortex through multiple anatomical loops that process sensory, limbic, and heteromodal information. Tract-tracing studies in monkey reveal these corticostriatal connections form stereotyped patterns striatum. Here organization of was explored human with resting-state functional connectivity MRI (fcMRI). Data from 1,000 subjects were registered nonlinear deformation combination surface-based alignment cortex. fcMRI maps derived seed regions placed...
Although it is being successfully implemented for exploration of the genome, discovery science has eluded functional neuroimaging community. The core challenge remains development common paradigms interrogating myriad systems in brain without constraints a priori hypotheses. Resting-state MRI (R-fMRI) constitutes candidate approach capable addressing this challenge. Imaging during rest reveals large-amplitude spontaneous low-frequency (<0.1 Hz) fluctuations fMRI signal that are temporally...
Recent evidence suggests that some brain areas act as hubs interconnecting distinct, functionally specialized systems. These nexuses are intriguing because of their potential role in integration and also they may augment metabolic cascades relevant to disease. To identify regions high connectivity the human cerebral cortex, we applied a computationally efficient approach map degree intrinsic functional across brain. Analysis two separate magnetic resonance imaging datasets (each n = 24)...
Alzheimer's disease (AD) and antecedent factors associated with AD were explored using amyloid imaging unbiased measures of longitudinal atrophy in combination reanalysis previous metabolic functional studies. In total, data from 764 participants compared across five vivo methods. Convergence effects was seen posterior cortical regions, including cingulate, retrosplenial, lateral parietal cortex. These regions active default states young adults also showed deposition older AD. At early...
Abstract Nine previous positron emission tomography (PET) studies of human visual information processing were reanalyzed to determine the consistency across experiments blood flow decreases during active tasks relative passive viewing same stimulus array. Areas showing consistent included posterior cingulate/precuneous (Brodmann area, BA 31/7), left (BAS 40 and 39/19) right (BA 40) inferior parietal cortex, dorsolateral frontal cortex S), lateral 10/47), temporal gyrus @A 20), a strip medial...
Resting state functional connectivity MRI (fcMRI) is widely used to investigate brain networks that exhibit correlated fluctuations. While fcMRI does not provide direct measurement of anatomic connectivity, accumulating evidence suggests it sufficiently constrained by anatomy allow the architecture distinct systems be characterized. particularly useful for characterizing large-scale span distributed areas (e.g., polysynaptic cortical pathways, cerebro-cerebellar circuits, cortical-thalamic...
Two functionally distinct, and potentially competing, brain networks have been recently identified that can be broadly distinguished by their contrasting roles in attention to the external world versus internally directed mentation involving long-term memory. At core of these two are dorsal system hippocampal-cortical memory system, a component brain's default network. Here spontaneous blood-oxygenation-level-dependent (BOLD) signal correlations were used three separate functional magnetic...
Abstract The Open Access Series of Imaging Studies is a series magnetic resonance imaging data sets that publicly available for study and analysis. initial set consists cross-sectional collection 416 subjects aged 18 to 96 years. One hundred the included older than 60 years have been clinically diagnosed with very mild moderate Alzheimer's disease. are all right-handed include both men women. For each subject, three or four individual T1-weighted scans obtained in single sessions included....