A5079547959- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Mental Health and Psychiatry
- Receptor Mechanisms and Signaling
- Genetics and Neurodevelopmental Disorders
- Genetic Associations and Epidemiology
- Autism Spectrum Disorder Research
- Schizophrenia research and treatment
- Genomics and Rare Diseases
- Mental Health Research Topics
- Neuroethics, Human Enhancement, Biomedical Innovations
- Memory and Neural Mechanisms
- Personality Disorders and Psychopathology
- Neuropeptides and Animal Physiology
- Functional Brain Connectivity Studies
- Stress Responses and Cortisol
- Bioinformatics and Genomic Networks
- Child and Adolescent Psychosocial and Emotional Development
- Treatment of Major Depression
- Bipolar Disorder and Treatment
- Health, Environment, Cognitive Aging
- Mental Health Treatment and Access
- Attention Deficit Hyperactivity Disorder
- Neuroendocrine regulation and behavior
- Health Systems, Economic Evaluations, Quality of Life
Harvard University
2014-2024
Broad Institute
2015-2024
Massachusetts Institute of Technology
2012-2024
Stanley Center for Psychiatric Research
2024
Harvard University Press
2004-2023
Stanley Foundation
2023
Harvard Stem Cell Institute
2011-2022
Massachusetts General Hospital
1987-2021
University of Southern California
2006-2021
University of California, Los Angeles
2021
Following approval of the ICD‐11 by World Health Assembly in May 2019, Organization (WHO) member states will transition from ICD‐10 to ICD‐11, with reporting health statistics based on new system begin January 1, 2022. The WHO Department Mental and Substance Abuse publish Clinical Descriptions Diagnostic Guidelines (CDDG) for Mental, Behavioural Neurodevelopmental Disorders following ICD‐11’s approval. development CDDG over past decade, principles clinical utility global applicability, has...
Dopaminergic neurons exert a major modulatory effect on the forebrain. Dopamine and adenosine 3′,5′-monophosphate–regulated phosphoprotein (32 kilodaltons) (DARPP-32), which is enriched in all that receive dopaminergic input, converted response to dopamine into potent protein phosphatase inhibitor. Mice generated contain targeted disruption of DARPP-32 gene showed profound deficits their molecular, electrophysiological, behavioral responses dopamine, drugs abuse, antipsychotic medication....
Chronic treatment of rats with cocaine leads to long-term biochemical changes in the nucleus accumbens (NAc), a brain region implicated mediating reinforcing effects and other drugs abuse. Immediate early genes (IEGs) their protein products appear play an important role transducing extracellular stimuli into altered patterns cellular gene expression and, therefore, functioning. We therefore examined mRNA levels for IEGs c-fos, c-jun, fosB, junB, zif268 NAc treated acutely chronically...
The World Health Organization is in the process of preparing eleventh revision International Classification Diseases (ICD-11), scheduled for presentation to Assembly approval 2017. Advisory Group Revision ICD-10 Mental and Behavioural Disorders made improvement clinical utility an organizing priority revision. uneven nature diagnostic information included Clinical Descriptions Diagnostic Guidelines (CDDG), especially with respect differential diagnosis, a major shortcoming terms its...
Drug discovery is at a near standstill for psychiatric disorders such as schizophrenia, bipolar disorder, and depression.