A5010932294- Wireless Communication Networks Research
- Advanced Wireless Communication Techniques
- Speech and Audio Processing
- Speech Recognition and Synthesis
- Advanced Data Compression Techniques
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Phonetics and Phonology Research
- Estrogen and related hormone effects
- Neurotransmitter Receptor Influence on Behavior
- Advanced MIMO Systems Optimization
- Ion channel regulation and function
- Advanced Wireless Network Optimization
- Hypothalamic control of reproductive hormones
- Natural Language Processing Techniques
- Music and Audio Processing
- Stress Responses and Cortisol
- Advanced Adaptive Filtering Techniques
- Power Line Communications and Noise
- Digital Filter Design and Implementation
- Speech and dialogue systems
- Signaling Pathways in Disease
- Neuroendocrine regulation and behavior
- Neuropeptides and Animal Physiology
- Image and Signal Denoising Methods
University of Minnesota
2015-2025
Twin Cities Orthopedics
2020-2024
University of Minnesota System
2016
Institut National de la Recherche Scientifique
1998-2008
Université du Québec à Montréal
2002-2008
University of Miami
2008
McGill University
1983-2005
Haskins Laboratories
1974-2005
Bell (Canada)
1982-2005
Natural Sciences and Engineering Research Council
2003
Several parametric representations of the acoustic signal were compared with regard to word recognition performance in a syllable-oriented continuous speech system. The vocabulary included many phonetically similar monosyllabic words, therefore emphasis was on ability retain significant information face syntactic and duration variations. For each parameter set (based mel-frequency cepstrum, linear frequency prediction spectrum, or reflection coefficients), templates generated using an...
The group I metabotropic glutamate receptors (mGluR1a and mGluR5) are important modulators of neuronal structure function. Although these share common signaling pathways, they capable having distinct effects on cellular plasticity. We investigated the individual mGluR1a or mGluR5 activation dendritic spine density in medium spiny neurons nucleus accumbens (NAc), which has become relevant with potential use mGluR based therapeutics treatment drug addiction. found that systemic administration...
Dopaminergic neurons exert a major modulatory effect on the forebrain. Dopamine and adenosine 3′,5′-monophosphate–regulated phosphoprotein (32 kilodaltons) (DARPP-32), which is enriched in all that receive dopaminergic input, converted response to dopamine into potent protein phosphatase inhibitor. Mice generated contain targeted disruption of DARPP-32 gene showed profound deficits their molecular, electrophysiological, behavioral responses dopamine, drugs abuse, antipsychotic medication....
In addition to mediating sexual maturation and reproduction through stimulation of classical intracellular receptors that bind DNA regulate gene expression, estradiol is also thought influence various brain functions by acting on localized the neuronal membrane surface. Many signaling pathways modulatory proteins are affected via this unconventional route, including regulation transcription factor cAMP response element-binding protein (CREB). However, mechanisms which acts at surface poorly...
Study of midsagittal x-ray tracings reveals that the vocal-tract outline can be accurately represented by means variables specifying positions jaw, tongue body, tip, lips, velum, and hyoid. As articulators move, they modify cross-sectional area transfer function computed thereform. The speech signal may synthesized concatenating responses to repeated excitation quasistatic vocal tract. Vowels are specified in terms denoting velum. Consonants implemented as transformations on underlying...
As a first step toward automatic phonetic analysis of speech, one desires to segment the signal into syllable-sized units. Experiments were conducted in segmentation techniques for continuous, reading-rate speech derive such A new algorithm is described that allows assessment significance loudness minimum be potential syllabic boundary from difference between convex hull function and itself. Tested on roughly 400 syllables continuous text, results 6.9% missed 2.6% extra relative nominal,...
In rats, female sexual behavior is regulated by a well defined limbic–hypothalamic circuit that integrates sensory and hormonal information. Estradiol activation of this results in μ-opioid receptor (MOR) internalization the medial preoptic nucleus, an important step for full expression receptivity. acts through both membrane intracellular receptors to influence neuronal activity behavior, yet mechanism(s) physiological significance estradiol-mediated responses vivo have remained elusive....
It has become widely accepted that along with its ability to directly regulate gene expression, estradiol also influences cell signaling and brain function via rapid membrane-initiated events. Many of these novel processes are dependent on estrogen receptors (ERs) localized the neuronal membrane. However, mechanism(s) by which ERs able trigger when targeted membrane surface yet be determined. In hippocampal neurons, we find caveolin proteins essential for regulation CREB (cAMP response...
Activity-dependent gene expression in neurons shows a remarkable ability to differentiate between different types of stimulation: orthodromic inputs that engage synaptic transmission are much more effective than antidromic stimuli do not. We have studied the basis such selectivity cultured hippocampal which nuclear cAMP response element-binding protein (CREB) phosphorylation is induced by activity but not action potential (AP) stimulation absence EPSPs, although spikes themselves generate...
A software articulatory synthesizer, based upon a model developed by P. Mermelstein [J. Acoust. Soc. Am. 53, 1070–1082 (1973)], has been implemented on laboratory computer. The synthesizer is designed as tool for studying the linguistically and perceptually significant aspects of events. prominent feature this system that it easily permits modification limited set key parameters control positions major articulators: lips, jaw, tongue body, tip, velum, hyoid bone. Time-varying over...
We model the vocal tract as a lossless acoustic tube and consider relationship between resonant frequencies cross-sectional area function. Empirical results show that if logarithm of function is band limited preserving only 2n Fourier components, lowest n pole zero admittance measured at lips uniquely determine coefficients. The formant determined from speech signal, normal tract, correspond to poles. They alone do not suffice for unique determination unless even coefficients are constrained...
Five groups of ovariectomized rats were tested during in vivo microdialysis, and concentrations dopamine (DA) its metabolites determined dialysate. In striatum, DA increased more hormone-primed female pacing copulation than those engaging sex that could not pace, hormone primed but without a male present, or oil-treated (p < .02). Administration estrogen before microdialysis resulted enhanced striatal response to rat relative the animals .06). Female sexual behavior also exhibited greater...
A member of the neurotrophin family, brain-derived neurotrophic factor (BDNF) regulates neuronal survival and differentiation during development. Within adult brain, BDNF is also important in adaptive processes, such as activity-dependent plasticity that underlies learning memory. These long-term changes synaptic strength are mediated through alterations gene expression. However, many mechanisms by which linked to transcriptional translational regulation remain unknown. Recently,...
An exploratory implementation of a syllable-based recognizer is described. Continuous speech first divided into syllabic units, and the units are then matched against syllable templates using dynamic programming algorithm. A hierarchical transition network used to limit search possible continuations current partial sentence hypotheses. Competing hypotheses pruned by 'beam search'. Experiments reported on automatic recognition English sentences with 70-word vocabulary restricted syntax...