A5083780025- Lipid Membrane Structure and Behavior
- Cellular transport and secretion
- Neuroscience and Neuropharmacology Research
- Mitochondrial Function and Pathology
- Hemoglobin structure and function
- Alzheimer's disease research and treatments
- Biomedical Text Mining and Ontologies
- Photoreceptor and optogenetics research
- Retinal Diseases and Treatments
- Machine Learning in Bioinformatics
- Genetics and Neurodevelopmental Disorders
- Ocular Diseases and Behçet’s Syndrome
- Neonatal Health and Biochemistry
- Lung Cancer Research Studies
- S100 Proteins and Annexins
- Trace Elements in Health
- Glycosylation and Glycoproteins Research
- Cardiovascular and Diving-Related Complications
- Nerve injury and regeneration
- Congenital heart defects research
- Bioinformatics and Genomic Networks
- Autism Spectrum Disorder Research
- Retinal and Macular Surgery
- Erythrocyte Function and Pathophysiology
Roche Pharma AG (Germany)
2022
Max Planck Institute for Biophysical Chemistry
2014-2019
Neurotransmitter release is mediated by the fast, calcium-triggered fusion of synaptic vesicles with presynaptic plasma membrane, followed endocytosis and recycling membrane vesicles. While many proteins governing these processes are known, their regulation only beginning to be understood. Here we have applied quantitative phosphoproteomics identify changes in phosphorylation status resting stimulated nerve terminals isolated from brains Wistar rats. Using rigorous quantification, identified...
Delivery of neurotrophins and neuropeptides via long-range trafficking dense core vesicles (DCVs) from the cell soma to nerve terminals is essential for synapse modulation circuit function. But mechanism by which transiting DCVs are captured at specific sites unknown. Here, we discovered that Synaptotagmin-4 (Syt4) regulates capture spatial distribution in hippocampal neurons. We found highly mobile undergo translocation but switch directions only distal ends axons, revealing a circular...
Alzheimer’s disease is the most prevalent neurodegenerative disorder leading to progressive cognitive decline. Despite decades of research, understanding AD progression at molecular level, especially its early stages, remains elusive. Here, we identified several presymptomatic markers by investigating brain proteome changes over course neurodegeneration in a transgenic mouse model (3×Tg-AD). We show that one these markers, heme-binding protein 1 (Hebp1), elevated brains both 3×Tg-AD mice and...
Autism spectrum disorders (ASDs) are neurodevelopmental characterized by impaired social interaction and communication, restricted behavior interests. A disruption in the balance of excitatory inhibitory neurotransmission has been hypothesized to underlie these disorders. Here we demonstrate that genes both pathways affected ASD, gene expression is altered cerebral cortex adult but not younger autistic individuals. We have developed a measure for difference level excitation inhibition based...
X-linked retinoschisis (XLRS) is a vitreoretinal degenerative disorder causing vision deterioration, due to structural defects in retina. The hallmark of this disease includes radial streaks arising from the fovea and splitting inner retinal layers (schisis). Although these changes are attributed mutations retinoschisin gene, schisis also observed patients who do not carry mutations. In addition, origin intraschisis fluid, triggering point formation its progression largely unknown still. So...
Haptoglobin (Hp) is an abundant acute-phase protein secreted mainly by the liver into bloodstream. There are three Hp phenotypes (Hp type 1-1, 2-1, and 2-2), which differ in number of α- β-chains, α-chain (the β-chain remains same all phenotypes), polymers that they form via disulfide bonds. has four N-glycosylation sites on β-chain. Glycosylation been reported frequently as a potential glycobiomarker for many diseases; however, whether polymorphism affects its glycosylation not yet...
Background There is a need for new serum biomarkers early detection of hepatocellular carcinoma (HCC). Haptoglobin (Hp) N-glycosylation altered in HCC, but the diagnostic value site-specific Hp glycobiomarkers rarely reported. We aimed to determine glycosylation profile early-stage HCC diagnosis. Method was analyzed plasma patients with liver diseases (n=57; controls), (n=50) and late-stage (n=32). phenotype determined by immunoblotting. immunoisolated digested into peptides. N-glycopeptides...