A5089747839- Metabolomics and Mass Spectrometry Studies
- Lipid Membrane Structure and Behavior
- Cellular transport and secretion
- Neuroscience and Neuropharmacology Research
- Hemoglobin structure and function
- Analytical Chemistry and Chromatography
- Cancer, Hypoxia, and Metabolism
- Microbial Metabolic Engineering and Bioproduction
- Mitochondrial Function and Pathology
- Photoreceptor and optogenetics research
Max Planck Institute for Biophysical Chemistry
2016
ETH Zurich
2009-2011
Life Science Zurich
2009
Quantitative metabolomics is under intense development, and no commonly accepted standard analytical technique has emerged, yet. The employed methods were mostly chosen based on educated guesses. So far, there been systematic cross-platform comparison of different separation detection for quantitative metabolomics. Generally, the chromatographic metabolites followed by their selective in a mass spectrometer (MS) most promising approach terms sensitivity power. Using defined mixture 91...
Neurotransmitter release is mediated by the fast, calcium-triggered fusion of synaptic vesicles with presynaptic plasma membrane, followed endocytosis and recycling membrane vesicles. While many proteins governing these processes are known, their regulation only beginning to be understood. Here we have applied quantitative phosphoproteomics identify changes in phosphorylation status resting stimulated nerve terminals isolated from brains Wistar rats. Using rigorous quantification, identified...