Magdalena Lange
A5007757699- Mast cells and histamine
- Urticaria and Related Conditions
- Asthma and respiratory diseases
- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Autoimmune Bullous Skin Diseases
- melanin and skin pigmentation
- Cutaneous lymphoproliferative disorders research
- Drug-Induced Adverse Reactions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Dermatology and Skin Diseases
- T-cell and B-cell Immunology
- Nail Diseases and Treatments
- Oral Health Pathology and Treatment
- Parvovirus B19 Infection Studies
- Eosinophilic Disorders and Syndromes
- Immunodeficiency and Autoimmune Disorders
- Cancer and Skin Lesions
- Plant Pathogens and Fungal Diseases
- Dermatological and Skeletal Disorders
- Cytokine Signaling Pathways and Interactions
- Veterinary Oncology Research
- Immunotherapy and Immune Responses
- Histiocytic Disorders and Treatments
- Immune Cell Function and Interaction
Gdańsk Medical University
2016-2025
Roche Pharma AG (Germany)
2014-2022
Medical University of Vienna
2021
University of Gdańsk
2015
Institut für Berufliche Aus- und Fortbildung
2012
Helmholtz Zentrum München
2011
Boehringer Ingelheim (Germany)
2008-2010
Institute of Bioinformatics and Systems Biology
2004
Schwarzwald-Baar Klinikum
2003
Mast cell activation (MCA) is common and occurs in a number of pathologic conditions, including IgE-dependent independent allergic reactions, atopic disorders, autoimmune processes, mastocytosis. In subset patients, no underlying disease known trigger MCA are found. When the symptoms severe, systemic, recurrent, accompanied by diagnostic increase serum tryptase level or other mast mediators, an syndrome (MCAS) may be diagnosed. these typically respond to drugs suppressing MCA, mediator...
Abstract Background In indolent systemic mastocytosis (ISM), several risk factors of disease progression have been identified. Previous studies, performed with limited patient numbers, also shown that the clinical course in ISM is stable and comparable to cutaneous (CM). The aim this project was compare prognosis patients CM. Methods We employed a dataset 1993 from registry European Competence Network on Mastocytosis (ECNM) outcomes Results found overall survival (OS) worse compared...
Hepatocellular carcinoma (HCC), the sixth most common cancer worldwide, has an incidence rate equal to mortality. Over 80% of HCC cases occur within a high‐risk population, mainly patients with both cirrhosis and chronic hepatitis B or C. With 5‐year survival ranging from <16% for advanced >90% early stage HCC, there is high medical need detection HCC. In this study, we systematically evaluated biomarkers mentioned in international guidelines peer‐reviewed literature surveillance...
Hypersensitivity reactions (HR) are common in mastocytosis. However, little is known about triggers and risk factors. The registry of the European Competence Network on Mastocytosis (ECNM) enables reliable studies a larger cohort mastocytosis patients. We assessed prevalence, factors HR adults with ECNM registry.
We present an interesting image of eruptive syringoma confirmed by histopathological assessment in a 37-year-old male who was consulted due to numerous brownish small macules and papules resembling maculopapular cutaneous mastocytosis (MPCM). show difficulties diagnosing ES, given its rare occurrence resemblance other dermatological disorders. Moreover, we discuss the role dermoscopy reflectance confocal microscopy differential diagnosis syringoma.
Summary Onychomycosis was considered uncommon in children. This survey carried out to estimate the frequency of fungal nail infections children and adolescents (0–18 years age) attending our clinic last decade gain more insight into aetiology clinics this entity paediatric age group. study is based on data obtained from 2320 suspected superficial infection. diagnosed 99 cases, representing 19.8% all mycologically confirmed mycoses (500 cases) material. Fingernail onychomycosis recognized 52...
In systemic mastocytosis (SM), the clinical features and survival vary greatly.Patient-related factors determining outcome in SM are largely unknown. Ivyspring International
Mastocytosis is a clonal disease of the hematopoietic stem cell. The condition consists heterogeneous group disorders characterized by pathological accumulation mast cells in tissues including skin, bone marrow, liver, spleen and lymph nodes. rare which occurs both children adults. Childhood onset mastocytosis usually cutaneous transient while adults commonly progresses to systemic form. heterogeneity clinical presentation typically related tissue cell burden, symptoms due release mediators,...
We previously reported that human carboxylesterase 1 (CES1), a serine esterase containing unique N-linked glycosyl group at Asn79 (N79 CES1), is candidate serological marker of hepatocellular carcinoma (HCC). CES1 normally present low-to-undetectable levels in normal plasma, HCC tumors, and major liver cancer cell lines. To investigate the potential mechanism underlying suppression expression cells, we took advantage low detectability this tumors by overexpressing multiple lines, including...