A5006306448- Mast cells and histamine
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Eosinophilic Disorders and Syndromes
- Food Allergy and Anaphylaxis Research
- Asthma and respiratory diseases
- Chronic Lymphocytic Leukemia Research
- Allergic Rhinitis and Sensitization
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Urticaria and Related Conditions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Polyamine Metabolism and Applications
- Monoclonal and Polyclonal Antibodies Research
- Protein Degradation and Inhibitors
- Click Chemistry and Applications
- melanin and skin pigmentation
- Drug-Induced Adverse Reactions
- Acute Lymphoblastic Leukemia research
- Multiple Myeloma Research and Treatments
- Hematopoietic Stem Cell Transplantation
- Contact Dermatitis and Allergies
- Autoimmune Bullous Skin Diseases
- Hematological disorders and diagnostics
- Lymphoma Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
Medical University of Vienna
2016-2025
Ludwig Boltzmann Institute for Digital Health and Prevention
2019-2025
Vienna General Hospital
2007-2024
Hanusch Hospital
2008-2024
Comprehensive Cancer Center Vienna
2012-2024
University of Vienna
2006-2023
TU Wien
2020-2023
Massachusetts General Hospital
2023
University of Oxford
2023
Slovak University of Technology in Bratislava
2020-2022
Purpose The karyotype is a strong independent prognostic factor in myelodysplastic syndromes (MDS). Since the implementation of International Prognostic Scoring System (IPSS) 1997, knowledge concerning impact abnormalities has increased substantially. present study proposes new and comprehensive cytogenetic scoring system based on an international data collection 2,902 patients. Patients Methods were included from German-Austrian MDS Study Group (n = 1,193), Risk Analysis Workshop 816),...
A complementary DNA encoding a pollen allergen from white birch ( Betula verrucosa ) that was isolated library with serum immunoglobulin E pollen-allergic individual revealed significant sequence homology to profilins. The recombinant protein showed high affinity poly-L-proline. Immunoglobulin antibodies allergic individuals bound natural and profilin also human profilin. In addition, induced histamine release blood basophils of profilin-allergic individuals, but not sensitized other plant...
Type I allergy is a major health problem in industrialized countries where up to 15% of the population suffer from allergic symptoms (rhinitis, conjunctivitis, and asthma). Previously, we identified cDNA clone that encoded birch pollen allergen as profilin. Profilins constitute ubiquitous family proteins control actin polymerization eukaryotic cells; particular, profilin participates acrosomal reaction animal sperm cells. Although profilins had been unknown plants so far, our finding led...
Activation of tissue mast cells (MCs) and their abnormal growth accumulation in various organs are typically found primary MC disorders also referred to as mastocytosis. However, increasing numbers patients now being informed that clinical findings due activation (MCA) is neither associated with mastocytosis nor a defined allergic or inflammatory reaction. In other MCA, MCs appear be clonal cells, but criteria for diagnosing not met. A working conference was organized 2010 the aim define MCA...
BACKGROUND: Risk stratification and therapeutic decision-making for myelodysplastic syndromes (MDS) are based on the International Prognostic Scoring System–Revised (IPSS-R), which considers hematologic parameters cytogenetic abnormalities. Somatic gene mutations not yet used in risk of patients with MDS. METHODS: To develop a clinical-molecular prognostic model (IPSS-Molecular [IPSS-M]), pretreatment diagnostic or peridiagnostic samples from 2957 MDS were profiled 152 genes. Clinical...
Advanced systemic mastocytosis comprises rare hematologic neoplasms that are associated with a poor prognosis and lack effective treatment options. The multikinase inhibitor midostaurin inhibits KIT D816V, primary driver of disease pathogenesis. We conducted an open-label study oral at dose 100 mg twice daily in 116 patients, whom 89 mastocytosis-related organ damage were eligible for inclusion the efficacy population; 16 had aggressive mastocytosis, 57 neoplasm, mast-cell leukemia. outcome...
The discipline of Cardio-Oncology has seen tremendous growth over the past decade. It is devoted to cardiovascular (CV) care cancer patient, especially mitigation and management CV complications or toxicities therapies, which can have profound implications on prognosis. To that effect, many studies assessed in patients undergoing various types therapies; however, direct comparisons proven difficult due lack uniformity toxicity endpoints. Similarly, clinical practice, there be substantial...
The history of phenothiazines, from methylene blue via chlorpromazine to recently synthesized isomeric derivatives various neuroleptics, is reviewed in the light their antimicrobial activity and Paul Ehrlich's receptor concept. latter clearly line with most modern theories concerning drug action stereo-isomeric compounds.
Objective — A number of studies have shown that statins decrease morbidity and mortality in patients with cardiovascular diseases. The anti-inflammatory effects recently been implicated the clinical benefit can be obtained treatment atherosclerosis. Little is known about mechanisms by which counteract inflammation. Methods Results In this study, we asked whether simvastatin influence vitro vivo production proinflammatory cytokines interleukin (IL)-6, IL-8, monocyte chemoattractant protein-1....
IgE-mediated allergy affects >25% of the population in industrialized countries. Repeated contact with disease-eliciting allergens induces rises allergen-specific IgE Abs and progression disease to more severe manifestations. Our study uses a type vaccine that is based on genetically modified allergen derivatives treat allergic patients. We developed hypoallergenic major birch pollen allergen, Bet v 1, by genetic engineering vaccinated pollen-allergic patients (n = 124) double-blind,...