A5082893222- Acute Myeloid Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Multiple Myeloma Research and Treatments
- Cancer Genomics and Diagnostics
- Chronic Myeloid Leukemia Treatments
- Hemoglobinopathies and Related Disorders
- Immune Cell Function and Interaction
- Blood groups and transfusion
- Protein Degradation and Inhibitors
- Cutaneous lymphoproliferative disorders research
- Acute Lymphoblastic Leukemia research
- Immunodeficiency and Autoimmune Disorders
- Hematological disorders and diagnostics
- Viral-associated cancers and disorders
- Blood disorders and treatments
- Autoimmune and Inflammatory Disorders Research
- Erythrocyte Function and Pathophysiology
- CAR-T cell therapy research
- Childhood Cancer Survivors' Quality of Life
- Heparin-Induced Thrombocytopenia and Thrombosis
- T-cell and Retrovirus Studies
- Platelet Disorders and Treatments
- Parvovirus B19 Infection Studies
Chulalongkorn University
2014-2024
King Chulalongkorn Memorial Hospital
2014-2024
Thai Red Cross Society
2020
Cleveland Clinic
2013-2017
Srinakharinwirot University
2009-2013
Abstract Germ line DDX41 variants have been implicated in late-onset myeloid neoplasms (MNs). Despite an increasing number of publications, many important features DDX41-mutated MNs remain to be elucidated. Here we performed a comprehensive characterization MNs, enrolling total 346 patients with pathogenic/likely-pathogenic (P/LP) germ and/or somatic mutations from 9082 MN patients, together 525 first-degree relatives and wild-type (WT) patients. P/LP explained ∼80% known predisposition...
Abstract Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare subtype of peripheral affecting younger patients and associated with hemophagocytic lymphohistiocytosis. To clarify the molecular pathogenesis SPTCL, we analyzed paired tumor germline DNAs from 13 by whole-exome sequencing. All cases were Asians phenotypically sporadic no family history SPTCL. Consistent recent report, mutations in HAVCR2, encoding immunoglobulin mucin 3 (TIM3), identified 11 (85%) cases. mutated...
Angioimmunoblastic T-cell lymphoma (AITL) is a nodal-based mature with distinctive clinical symptomatology and histology. Research into its pathogenesis supports cellular derivation from follicular helper T cells overexpression of genes related to B cells, dendritic vascular growth. Recently, novel recurring somatic mutation in RHOA, encoding p.Gly17Val, was discovered nearly 70% AITLs smaller proportion peripheral lymphomas, not otherwise specified (PTCL-NOS). We investigated series compare...
// Naoko Hosono 1, 2 , Hideki Makishima * Reda Mahfouz 1 Bartlomiej Przychodzen Kenichi Yoshida 3, 4 Andres Jerez Thomas LaFramboise 5 Chantana Polprasert Michael J. Clemente Yuichi Shiraishi 6 Chiba Hiroko Tanaka 7 Satoru Miyano 6, Masashi Sanada Edward Cui Amit K. Verma 8 A. McDevitt 9 Alan F. List 10 Yogen Saunthararajah Mikkael Sekeres 12, 13 Jacqueline Boultwood Seishi Ogawa Jaroslaw P. Maciejewski 11, Department of Translational Hematology and Oncology Research, Taussig Cancer...
Abstract High-dose methotrexate (HD-MTX) is a widely used chemotherapy regimen for hematologic malignancies such as lymphomas and acute lymphoblastic leukemia, but its use can lead to adverse effects, including kidney injury (AKI), impaired liver function, mucositis, causing extended hospital stays delayed subsequent chemotherapy. Our study aimed investigate the predictive factors renal toxicities associated with HD-MTX in Thai patients undergoing treatment malignancies. We enrolled 80 who...
The programmed cell death 1/programmed ligands (PD-1/PD-Ls) axis is a potential immune escape mechanism of cancers. However, data on the PD-1/PD-Ls pathway in EBV-associated extranodal natural killer/T lymphoma (ENKTL) and its clinical implication are limited. Herein, we characterized PD-1/PD-L expression prognosis relevance 49 ENKTL patients Thailand. PD-L1 was expressed frequently both cells (61.2%) stroma (77.5%), whereas PD-L2 more common (63.2%) than stromal cells. PD-1 positive 20.5%...
Nano-delivery of natural compounds has gained increasing attention in the food and pharmaceutical ingredients industry. Avocado seed was extracted by a total lipid extraction presence two acetogenin confirmed high-performance liquid chromatography (LC-MS) technique. Then, avocado extract (Avo) encapsulated into zein nanoparticles liquid-liquid dispersion formation loaded with (Avo-ZNPs) FTIR analysis. The Avo-ZNPs various Avo contents showed an average size ranging from 166.9 ± 14.1 to 305.2...
Next generation sequencing technologies have provided insights into the molecular heterogeneity of various myeloid neoplasms, revealing previously unknown somatic genetic events. In our cohort 1444 cases analyzed by next sequencing, mutations in gene BRCA1-BRCA2-containing complex 3 (BRCC3) were identified 28 (1.9%). BRCC3 is a member JAMM/MPN+ family zinc metalloproteases capable cleaving Lys-63 linked polyubiquitin chains, and implicated DNA repair. The located throughout its coding...
Extranodal NK/T cell lymphomas (ENKTCLs) are aggressive Epstein-Barr virus-associated T/NK neoplasms that predominantly affect Asians. To explore the causative somatic events, we conducted a comprehensive genetic analysis of 19 ENKTCL patients by whole-genome (N = 2), whole-exome 16), and targeted sequencing 15). Commonly deregulated gene pathways in ENKTCLs included epigenetic modifiers (58%, 11/19) followed human leukocyte antigens (HLAs) related genes including HLA-A, B2M, TAP1, CD274,...
T-cell prolymphocytic leukemia (T-PLL) is a rare, mature which usually presents with aggressive behavior. We report an asymptomatic T-PLL patient diagnosed by clinical features, lymphocyte morphology, and flow cytometry. Incidentally, she was found to have lymphocytosis lymphadenopathy. Flow cytometry from blood revealed abnormally increased CD4+ population. receptor clonality assessment next-generation sequencing dominant clone in the ß-chain constant region. No pathogenic mutations 25...
Anemia is one of the most common problems in chronic kidney disease (CKD). In several cases, despite comprehensive investigations, definite causes anemia frequently remain unknown. We aimed to analyze factors that possibly affect CKD patients who were referred for hematology consultation. A total 87 retrospectively included cohort. Forty-four cases excluded, 30 with unavailable intact parathyroid hormone (iPTH) data, 11 bone marrow diseases (8 Pure red cell aplasia, 3 Myelodysplastic...
Background: We identified 3 adolescents with alpha-beta subtype subcutaneous panniculitis-like T-cell lymphoma. Case Presentation: Three patients presented prolonged fever, abnormal skin lesions, and cytopenia described in the context. All had same disease entity, which showed duration of B systemic symptoms till diagnosis, difficulty to distinguish from autoimmune diseases, presence hemophagocytic lymphohistiocytosis syndrome, good response, remained on long-term remission nonchemotherapy...
Adult immune thrombocytopenia (ITP) commonly relapses after stopping treatments. This may be preventable by low-dose steroids. In this multicenter study, adult patients with ITP who had been responding to corticosteroids were randomized the 2 strata of newly diagnosed and relapsed prednisolone 7.5 mg/d or observation for 6 months. Relapses defined a platelet count below 30 × 10 9 /L and/or clinical bleeding. There 75 evaluable efficacy 77 safety. The recurrent comprised 57.3%. During median...
SARS-CoV-2 and other respiratory co-infections may occur. As Mycoplasma pneumoniae various viruses can cause cold agglutinin disease (CAD), the presence of CAD in COVID-19 patients should indicate need investigations for those pathogens.