Kelly L. Bolton
A5035097079- Acute Myeloid Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Ovarian cancer diagnosis and treatment
- Cancer, Lipids, and Metabolism
- Neutropenia and Cancer Infections
- Childhood Cancer Survivors' Quality of Life
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Gene expression and cancer classification
- Radiomics and Machine Learning in Medical Imaging
- Hematopoietic Stem Cell Transplantation
- Hematological disorders and diagnostics
- RNA modifications and cancer
- AI in cancer detection
- Cancer-related molecular mechanisms research
- PARP inhibition in cancer therapy
- BRCA gene mutations in cancer
- Multiple Myeloma Research and Treatments
- Hemoglobinopathies and Related Disorders
- Acute Lymphoblastic Leukemia research
- Single-cell and spatial transcriptomics
- Prostate Cancer Treatment and Research
- Chromatin Remodeling and Cancer
- Epigenetics and DNA Methylation
- Hormonal Regulation and Hypertension
Washington University in St. Louis
2020-2025
Memorial Sloan Kettering Cancer Center
2018-2023
Cancer Research UK
2009-2023
University of Cambridge
2009-2023
Division of Cancer Epidemiology and Genetics
2010-2023
NYU Langone Health
2023
Emory University
2023
Cancer Genetics (United States)
2011-2023
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2022
Cornell University
2006-2020
Context-Approximately 10 percent of women with invasive epithelial ovarian cancer (EOC) carry deleterious germline mutations in BRCA1 or BRCA2.A recent report suggested that BRCA2 related EOC was associated an improved prognosis, but the effect remains unclear.Objective-To characterize survival BRCA carriers compared to non-carriers and determine whether show similar patterns.Design, Setting, Participants-We pooled data from 26 studies on cancer.This included 1,213 cases pathogenic (909)...
Coronavirus-2019 (COVID-19) mortality is higher in patients with cancer than the general population, yet cancer-associated risk factors for COVID-19 adverse outcomes are not fully characterized.
Although clonal hematopoiesis (CH) is well described in aging healthy populations, few studies have addressed the practical clinical implications of these alterations solid-tumor sequencing.To identify and quantify CH-related mutations patients with solid tumors using matched tumor-blood sequencing, to establish proportion that would be misattributed tumor based on tumor-only sequencing (unmatched analysis).Retrospective analysis samples from 17 469 cancers who underwent prospective DNA...
Acquired somatic mutations in hematopoietic stem and progenitor cells (clonal hematopoiesis or CH) are associated with advanced age, increased risk of cardiovascular malignant diseases, decreased overall survival. These adverse sequelae may be mediated by altered inflammatory profiles observed patients CH. A pro-inflammatory immunologic profile is also worse outcomes certain infections, including SARS-CoV-2 its disease Covid-19. Whether CH predisposes to severe Covid-19 other infections...
Spaceflight induces molecular, cellular and physiological shifts in astronauts poses myriad biomedical challenges to the human body, which are becoming increasingly relevant as more humans venture into space
To analyze the effect of germline mutations in BRCA1 and BRCA2 on mortality patients with ovarian cancer up to 10 years after diagnosis.
Genome-wide association studies (GWAS) have mapped risk alleles for at least 10 distinct cancers to a small region of 63 000 bp on chromosome 5p15.33. This harbors the TERT and CLPTM1L genes; former encodes catalytic subunit telomerase reverse transcriptase latter may play role in apoptosis. To investigate further genetic architecture common susceptibility this region, we conducted an agnostic subset-based meta-analysis (association analysis based subsets) across six 34 248 cases 45 036...
Abstract Purpose: In this era of precision-based medicine, for optimal patient care, results reported from commercial next-generation sequencing (NGS) assays should adequately reflect the burden somatic mutations in tumor being sequenced. Here, we sought to determine prevalence clonal hematopoiesis leading possible misattribution mutation calls on unpaired Foundation Medicine NGS assays. Experimental Design: This was a retrospective cohort study individuals undergoing solid tumors two large...
Abstract Stably acquired mutations in hematopoietic cells represent substrates of selection that may lead to clonal hematopoiesis (CH), a common state cancer patients is associated with heightened risk leukemia development. Owing technical and sample size limitations, most CH studies have characterized gene or mosaic chromosomal alterations (mCAs) individually. Here we leverage peripheral blood sequencing data from 32,442 jointly characterize ( n = 14,789) mCAs 383) CH. Recurrent composite...
To identify molecular subclasses of clear cell ovarian carcinoma (CCOC) and assess their impact on clinical presentation outcomes.
To prospectively examine the association between clonal hematopoiesis (CH) and subsequent risk of lung cancer.
Abstract Background The Inspiration4 (I4) mission, the first all-civilian orbital flight investigated physiological effects of short-duration spaceflight through a multi-omic approach. Despite advances, there remains much to learn about human adaptation spaceflight's unique challenges, including microgravity, immune system perturbations, and radiation exposure. Methods To provide detailed genetics analysis we collected dried blood spots pre-, during, post-flight for DNA extraction. Telomere...