Jiwoon Park
A5003780992- Spaceflight effects on biology
- COVID-19 Clinical Research Studies
- Liver physiology and pathology
- COVID-19 and healthcare impacts
- SARS-CoV-2 and COVID-19 Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Single-cell and spatial transcriptomics
- Mercury impact and mitigation studies
- Isotope Analysis in Ecology
- Lung Cancer Diagnosis and Treatment
- Marine and coastal ecosystems
- Long-Term Effects of COVID-19
- Liver Disease Diagnosis and Treatment
- Pancreatic function and diabetes
- Health, Environment, Cognitive Aging
- Cancer Genomics and Diagnostics
- Medical and Biological Ozone Research
- RNA Interference and Gene Delivery
- High Altitude and Hypoxia
- Adenosine and Purinergic Signaling
- Digital Marketing and Social Media
- Impact of Technology on Adolescents
- Liver Disease and Transplantation
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Immune responses and vaccinations
Cornell University
2018-2025
Weill Cornell Medicine
2018-2025
Rockefeller University
2022-2023
University of Washington
2021-2023
Tri-Institutional PhD Program in Chemical Biology
2023
Korea University
2023
Sungkyunkwan University
2021
Cooper Union
2015
Social media influencer (SMI) advertising is on the rise; however, extant theory regarding determinants of SMI effectiveness undeveloped. The present research establishes when and how type based number followers influences effectiveness. Specifically, findings four experimental studies show that micro-influencers (those who have 10,000 to 100,000 followers) are more persuasive than mega-influencers 1 million because endorsements by (versus mega-influencers) bestow higher perceptions...
Spaceflight induces molecular, cellular and physiological shifts in astronauts poses myriad biomedical challenges to the human body, which are becoming increasingly relevant as more humans venture into space
Spaceflight induces an immune response in astronauts. To better characterize this effect, we generated single-cell, multi-ome, cell-free RNA (cfRNA), biochemical, and hematology data for the SpaceX Inspiration4 (I4) mission crew. We found that 18 cytokines/chemokines related to inflammation, aging, muscle homeostasis changed after spaceflight. In I4 single-cell multi-omics data, identified a "spaceflight signature" of gene expression characterized by enrichment oxidative phosphorylation, UV...
Maintenance of astronaut health during spaceflight will require monitoring and potentially modulating their microbiomes. However, documenting microbial shifts has been difficult due to mission constraints that lead limited sampling profiling. Here we executed a six-month longitudinal study quantify the high-resolution human microbiome response three days in orbit for four individuals. Using paired metagenomics metatranscriptomics alongside single-nuclei immune cell profiling, characterized...
Human spaceflight has historically been managed by government agencies, such as in the NASA Twins Study
A nanoreporter noninvasively detects endolysosomal lipids, revealing that short-term changes in diet have enduring effects on hepatic macrophages.
The molecular mechanisms underlying the clinical manifestations of coronavirus disease 2019 (COVID-19), and what distinguishes them from common seasonal influenza virus other lung injury states such as acute respiratory distress syndrome, remain poorly understood. To address these challenges, we combine transcriptional profiling 646 nasopharyngeal swabs 39 patient autopsy tissues to define body-wide transcriptome changes in response COVID-19. We then match data with spatial protein...
Abstract Spaceflight can change metabolic, immunological, and biological homeostasis cause skin rashes irritation, yet the molecular basis remains unclear. To investigate impact of short-duration spaceflight on skin, we conducted biopsies Inspiration4 crew members before (L-44) after (R + 1) flight. Leveraging multi-omics assays including GeoMx™ Digital Spatial Profiler, single-cell RNA/ATAC-seq, metagenomics/metatranscriptomics, assessed spatial gene expressions associated microbial immune...
Abstract Organismal adaptations to spaceflight have been characterized at the molecular level in model organisms, including Drosophila and C. elegans . Here, we extend work energy metabolism sex hormone signaling mice humans. We found induced changes insulin estrogen rodents Murine were most prominent liver, where observed inhibition of receptor with concomitant hepatic resistance steatosis. Based on metabolic demand, pathways mediated by vary among muscles, specifically between soleus...
Emerging research on social media influencer (SMI) marketing differentiates between micro-influencers and mega-influencers. In the present research, we establish that these two types of SMIs can yield different levels consumer intention to generate word mouth (WOM). Specifically, consumers are more likely WOM about endorsements made by micro- (vs. mega-) influencers. Importantly, however, such an effect SMI type occurs only when adopt a growth (but not fixed) mindset. This is because with...
Abstract Our previous research revealed a key microRNA signature that is associated with spaceflight can be used as biomarker and to develop countermeasure treatments mitigate the damage caused by space radiation. Here, we expand on this work determine biological factors rescued treatment. We performed RNA-sequencing transcriptomic analysis 3D microvessel cell cultures exposed simulated deep radiation (0.5 Gy of Galactic Cosmic Radiation) without antagonists three microRNAs: miR-16-5p,...
The GEOTRACES program has greatly expanded measurements of dissolved trace metal concentrations across ocean basins, but to understand the behavior and cycling metals their impacts on primary productivity, we must chemical forms in which they are present environment. Organic ligands play a central role speciation marine environment, controlling reactivity bioavailability. Here, an overview contributions made understanding through advancing our knowledge distribution, sources, sinks...
Abstract Background Spaceflight poses a unique set of challenges to humans and the hostile spaceflight environment can induce wide range increased health risks, including dermatological issues. The biology driving frequency skin issues in astronauts is currently not well understood. Methods To address this issue, we used systems approach utilizing NASA’s Open Science Data Repository (OSDR) on space flown murine transcriptomic datasets focused skin, biochemical profiles 50 NASA human...
Abstract We report here the use of a nanofibrous hydrogel as 3D scaffold for culture and maintenance functional primary human hepatocytes. The system is based on cooperative assembly fiber-forming peptide component, fluorenylmethyloxycarbonyl-diphenylalanine (Fmoc-FF), integrin-binding ligand, Fmoc-arginine-glycine-aspartic acid (Fmoc-RGD) into gel at physiological pH. This Fmoc-FF/RGD was formulated to provide biomimetic microenvironment with some critical features such mechanical...
Abstract Given the current status of coronavirus disease 2019 (COVID-19) as a global pandemic, it is high priority to gain deeper understanding disease's development and how virus impacts its host. Adenosine (A)-to-Inosine (I) RNA editing post-transcriptional modification, catalyzed by ADAR family enzymes, that can be considered part inherent cellular defense mechanism affects innate immune response in complex manner. It was previously reported various viruses could interact with host's...
Cell therapies have been groundbreaking for B-cell lymphomas but optimizing efficacy solid tumors remains challenging. Lack of consensus on potency measures, unknowns about novel engineering strategies, and product heterogeneity drive extensive characterization to discover product-specific mechanisms action (MoAs). This process is costly limited by variable results from simple molecular assays need infer relationships between data disparate technologies. Thus, we created a multi-modal...
Lethal COVID-19 outcomes are attributed to classic cytokine storm. We revisit this using RNA sequencing of nasopharyngeal and 40 autopsy samples from patients dying SARS-CoV-2. Subsets the 100 top-upregulated genes in nasal swabs upregulated heart, lung, kidney, liver, but not mediastinal lymph nodes. Twenty-two these “noncanonical” immune genes, which we link components renin-angiotensin-activation-system that manifest as increased fibrin deposition, leaky vessels, thrombotic tendency,...