A5021186956- Appendicitis Diagnosis and Management
- Ultrasound in Clinical Applications
- Emergency and Acute Care Studies
- SARS-CoV-2 and COVID-19 Research
- Wound Healing and Treatments
- Intestinal and Peritoneal Adhesions
- Sepsis Diagnosis and Treatment
- Pressure Ulcer Prevention and Management
- Diabetic Foot Ulcer Assessment and Management
- SARS-CoV-2 detection and testing
- Dermatology and Skin Diseases
- Diverticular Disease and Complications
- Long-Term Effects of COVID-19
- Psoriasis: Treatment and Pathogenesis
- Gastrointestinal disorders and treatments
- Spaceflight effects on biology
- Space Exploration and Technology
- Cardiac, Anesthesia and Surgical Outcomes
- COVID-19 Clinical Research Studies
- Hemodynamic Monitoring and Therapy
- Research on Leishmaniasis Studies
- Intraperitoneal and Appendiceal Malignancies
- Abdominal Surgery and Complications
- Urticaria and Related Conditions
- COVID-19 epidemiological studies
Brigham and Women's Hospital
2020-2024
Harvard Affiliated Emergency Medicine Residency
2019-2024
Massachusetts General Hospital
2019-2024
SpaceX (United States)
2020-2024
Harvard University
2020-2024
Seton Medical Center Austin
2024
Dana-Farber/Harvard Cancer Center
2022
University of Pennsylvania
2015-2019
Chronic nonhealing wounds have been heralded as a silent epidemic, causing significant morbidity and mortality especially in elderly, diabetic, obese populations. Polymicrobial biofilms the wound bed are hypothesized to disrupt highly coordinated sequential events of cutaneous healing. Both culture-dependent -independent studies chronic-wound microbiome almost exclusively focused on bacteria, omitting what we hypothesize important fungal contributions impaired healing development...
Human spaceflight has historically been managed by government agencies, such as in the NASA Twins Study
Given widespread use of spike antibody in generating coronavirus disease vaccines, SARS-CoV-2 nucleocapsid antibodies are increasingly used to indicate previous infection serologic surveys. However, longitudinal kinetics and seroreversion poorly defined. We found substantial total immunoglobulin, underscoring the need account for seroepidemiologic studies.
Abstract Objectives Difficult intravenous access (DIVA) is common in the emergency department (ED). We investigated extent to which DIVA associated with care delay outcomes including time first laboratory draw, therapies, imaging, and ED disposition. Methods An observational retrospective cohort analysis of patients treated between 2018 2020 at 2 urban academic EDs was performed. defined as requiring ultrasound‐guided placed by physicians or advanced practice providers (APPs) opposed...
Cutaneous leishmaniasis is a disease characterized by ulcerating skin lesions, the resolution of which requires an effective, but regulated, immune response that limits parasite growth without causing permanent tissue damage. While mechanisms control parasites have been well studied, factors regulating immunopathologic responses are less understood. IL-22, member IL-10 family cytokines, can contribute to wound healing, in other instances promotes pathology. Here we investigated role IL-22...
Identifying the potential for SARS-CoV-2 reinfection is crucial understanding possible long-term epidemic dynamics. We analysed longitudinal PCR and serological testing data from a prospective cohort of 4,411 United States employees in 4 states between April 2020 February 2021. conducted multivariable logistic regression investigating association baseline status subsequent test result order to calculate an odds ratio reinfection. estimated ranging 0.14 (95% CI: 0.019 0.63) 0.28 0.05 1.1),...
Introduction: Point-of-care ultrasound (POCUS) is an essential tool in the timely evaluation of undifferentiated patient emergency department (ED). Our primary objective this study was to determine perceived impact POCUS high-risk cases presented at medicine (EM) morbidity and mortality (M&M) conferences. Additionally, we sought identify which types patients might be most useful, applications were considered highest yield.Methods: This a retrospective survey submitted M&M EM residency...
Obesity is a key correlate of severe SARS-CoV-2 outcomes while the role obesity on risk infection, symptom phenotype, and immune response remain poorly defined. We examined data from prospective cohort study to address these questions. Serostatus, body mass index, demographics, comorbidities, prior COVID-19 compatible symptoms were assessed at baseline serostatus monthly thereafter. immunoassays included an IgG ELISA targeting spike RBD, multiarray Luminex 20 viral antigens, pseudovirus...
The concern for diverticulitis often leads to the use of computed tomography (CT) scans diagnosis. We aim develop an ultrasound-based clinical decision rule (CDR) confidently rule-out disease without requiring a CT scan. analyzed data from prospective study adult emergency department (ED) patients with suspected who underwent both bedside ultrasound (US) and CT. Patient history, physical examination, laboratory findings, US results were used create CDR via recursive partitioning model...
Abstract Study objective We sought to determine the ability of lung point‐of‐care ultrasound (POCUS) predict mechanical ventilation and in‐hospital mortality in patients with coronavirus disease 2019 (COVID‐19). Methods This was a prospective observational study convenience sample confirmed COVID‐19 presenting 2 tertiary hospital emergency departments (EDs) Iran between March April 2020. An physician attending sonographer performed 12‐zone bilateral all patients. Research associates followed...
Point-of-care ultrasound (US) has been suggested as the primary imaging in evaluating patients with suspected diverticulitis. Discrimination between simple and complicated diverticulitis may help to expedite emergent surgical consults determine risk of complications. This study aimed to: (1) accuracy an US protocol (TICS) for diagnosing emergency department (ED) setting (2) assess ability TICS distinguish diverticulitis.Patients clinically who underwent a diagnostic computed tomography (CT)...
Space travel has transformed in the past several years. Given burgeoning market for space tourism, in-flight medical emergencies are likely to be expected. Ultrasound is one of few diagnostic and therapeutic modalities available astronauts space. However, while point-of-care ultrasound (POCUS) available, there no current standard training astronaut preparation. We suggest an organized structured methodology by which should best prepare with equipment on board. As technology continues evolve,...
ABSTRACT BACKGROUND AND PURPOSE Ultrasound (US) measurement of the optic nerve sheath diameter (ONSD) and (OND) is a method frequently used to screen for an increased intracranial pressure. The aim this study was assess accuracy US measurements ONSD OND, when compared magnetic resonance imaging (MRI) as criterion standard. METHODS In prospective, single‐institution study, orbital performed those patients requiring emergent brain MRI. OND both eyes were measured in axial coronal planes...
ABSTRACT Chronic, non-healing wounds are a major complication of diabetes associated with high morbidity and health care expenditures estimated at $9-13 billion annually in the US. Though microbial infection critical colonization is hypothesized to impair healing contribute severe outcomes such as amputation, antimicrobial therapy inefficacious role microbes tissue repair, regeneration, remains unclear. Here, longitudinal prospective cohort study 100 subjects non-infected neuropathic...
Abstract Obesity is a key correlate of severe SARS-CoV-2 outcomes while the role obesity on risk infection, symptom phenotype, and immune response are poorly defined. We examined data from prospective cohort study to address these questions. Serostatus, body mass index, demographics, comorbidities, prior COVID-19 compatible symptoms were assessed at baseline serostatus monthly thereafter. immunoassays included an IgG ELISA targeting spike RBD, multiarray Luminex 20 viral antigens,...
<title>Abstract</title> The concern for diverticulitis often leads to the use of computed tomography (CT) scans diagnosis. We aim develop an ultrasound-based clinical decision rule (CDR) confidently rule-out disease without requiring a CT scan. analyzed data from prospective study adult emergency department (ED) patients with suspected who underwent both bedside ultrasound (US) and CT. Patient history, physical examination, laboratory findings, US results were used create CDR via recursive...