A5103124547- SARS-CoV-2 and COVID-19 Research
- Spaceflight effects on biology
- COVID-19 Clinical Research Studies
- Dental Health and Care Utilization
- Space Exploration and Technology
- Long-Term Effects of COVID-19
- Disaster Response and Management
- Respiratory Support and Mechanisms
- Global Health Workforce Issues
- Cardiovascular and Diving-Related Complications
- Cardiac Arrest and Resuscitation
- SARS-CoV-2 detection and testing
- COVID-19 epidemiological studies
- Monoclonal and Polyclonal Antibodies Research
- Bacillus and Francisella bacterial research
- Pituitary Gland Disorders and Treatments
- Augmented Reality Applications
- Surgical Simulation and Training
- Antimicrobial Resistance in Staphylococcus
- Airway Management and Intubation Techniques
- Immunotherapy and Immune Responses
- Traumatic Ocular and Foreign Body Injuries
- Cardiac Arrhythmias and Treatments
- Electronic Health Records Systems
- Muscle and Compartmental Disorders
University of Manitoba
2023-2025
Children's Hospital Research Institute of Manitoba
2024-2025
Walter Reed Army Institute of Research
2025
University of Maryland, Baltimore County
2025
Armed Forces Medical College
1998-2024
AAA College of Engineering and Technology
2024
The University of Texas Medical Branch at Galveston
2012-2024
Guy's and St Thomas' NHS Foundation Trust
2024
SpaceX (United States)
2020-2022
Armed Forces Medical College
2022
The successful development of several coronavirus disease 2019 (COVID-19) vaccines has substantially reduced morbidity and mortality in regions the world where have been deployed. However, wake emergence viral variants that are able to evade vaccine-induced neutralizing antibodies, real-world vaccine efficacy begun show differences across two approved mRNA platforms, BNT162b2 mRNA-1273; these findings suggest subtle variation immune responses induced by mRNA-1273 may confer differential...
SARS-CoV-2 mRNA vaccines confer robust protection against COVID-19, but the emergence of variants has generated concerns regarding protective efficacy currently approved vaccines, which lose neutralizing potency some variants. Emerging data suggest that antibody functions beyond neutralization may contribute to from disease, little is known about effector functions. Here, we profiled binding and functional capacity convalescent antibodies Moderna mRNA-1273 COVID-19 vaccine-induced across...
Human spaceflight has historically been managed by government agencies, such as in the NASA Twins Study
Abstract Antibodies serve as biomarkers of infection, but if sustained can confer long-term immunity. Yet, for most clinically approved vaccines, binding antibody titers only a surrogate protection. Instead, the ability vaccine induced antibodies to neutralize or mediate Fc-effector functions is mechanistically linked While evidence has begun point persisting responses among SARS-CoV-2 infected individuals, cases re-infection have emerge, calling protective nature humoral immunity against...
Preexisting cross-coronavirus immunity influences the early development of SARS-CoV-2 humoral after COVID-19.
The purpose of the study was to evaluate prevalence acute kidney injury (AKI) during a multi-stage ultramarathon foot race. A prospective observational taken Gobi 2008; Sahara and Namibia 2009 RacingThePlanet 7-day, 6-stage, 150-mile ultramarathons. Blood analyzed before, immediately after stage 1 (25 miles), 3 (75 5 (140 miles). Creatinine (Cr), glomerular filtration rate (GFR), incidence AKI were calculated defined by RIFLE criteria. Thirty participants (76% male, mean age 40 + 11 years)...
We describe the implementation details of a real-time surgical simulation system with soft-tissue modeling and multi-user, multi-instrument, networked haptics. The simulator is cross-platform runs on various Unix Windows platforms. It written in C++ OpenGL for graphics; GLUT, GLUI, MUI user interface; supports parallel processing. allows relatively easy introduction patient-specific anatomy many common file formats. performs modeling, some limited rigid-body dynamics, suture modeling....
Introduction In 2022, the federal government announced a commitment of $5.3B to provide dental care for uninsured, beginning with children <12 years age. Now referred as Interim Canada Dental Benefit (CDB), program targets those age from families annual incomes <$90,000 without private insurance. The purpose this study was review data Government on public uptake and applications made Revenue Agency (CRA) during first year CDB. Methods Data CDB (up June 30, 2023) were accessed...
Introduction: Canada’s national health insurance historically excluded dental care until the introduction of Interim Canada Dental Benefit (CBD) in October 2022. This represented a paradigm shift toward enhancing accessibility for children younger than 12 y from lower-income families. study investigated parents’ perspectives on access to oral and CDB. Methods: The Strategic Counsel Health collected data participants across using an online survey administered March 2023. Data were parents...
Two days after Haiti's devastating earthquake, a medical relief team made up in part of four emergency physicians and nurses from Stanford University Hospital three Columbia Medical Center traveled under the auspices International Corps, nonprofit organization based Los Angeles, to provide support. After an all-night bus ride Dominican Republic, arrived at Hopital de l'Universite d'Etat d'Haiti Port-au-Prince on morning January 17. The scene we faced was apocalyptic. Approximately 800...
Both teachers and students benefit from an interactive classroom. The teacher receives valuable input about effectiveness, student interest, comprehension, whereas participation, active learning, enjoyment of the class are enhanced. Cost deployment have limited use existing audience response systems, allowing anonymous linking in These limitations can be circumvented, however, by personal digital assistants (PDAs), which cheaper widely used students. In this study, authors equipped a summer...
We studied the effect of catheter position and flow rate on gas exchange during constant-flow ventilation (CFV) in eight anesthetized, paralyzed dogs. The distal tips insufflation catheters were positioned 0.5, 2.0, 3.5, 5.0 cm from tracheal carina. Flow rates varied between 10 55 l/min steady-state arterial blood gases measured. At a given rate, CO2 pressure (PaCO2) decreased as CFV was administered further into lung up to distance 3.5 carina; there no significant differences PaCO2 at cm....
Identifying the potential for SARS-CoV-2 reinfection is crucial understanding possible long-term epidemic dynamics. We analysed longitudinal PCR and serological testing data from a prospective cohort of 4,411 United States employees in 4 states between April 2020 February 2021. conducted multivariable logistic regression investigating association baseline status subsequent test result order to calculate an odds ratio reinfection. estimated ranging 0.14 (95% CI: 0.019 0.63) 0.28 0.05 1.1),...
Obesity is a key correlate of severe SARS-CoV-2 outcomes while the role obesity on risk infection, symptom phenotype, and immune response remain poorly defined. We examined data from prospective cohort study to address these questions. Serostatus, body mass index, demographics, comorbidities, prior COVID-19 compatible symptoms were assessed at baseline serostatus monthly thereafter. immunoassays included an IgG ELISA targeting spike RBD, multiarray Luminex 20 viral antigens, pseudovirus...
Abstract Introduction This study investigated parents’ perspectives on access to oral health care and the Interim Canada Dental Benefit (CDB). In context of Canada’s national insurance, which historically excluded dental care, introduction CDB in October 2022 represented a paradigm shift towards enhancing accessibility for children under 12 years age from lower-income families. Methods analyzed aggregate de-identified data comprehensive online survey conducted by The Strategic Counsel Health...
To study the etiological profile of short stature at a tertiary care hospital in north India.In this prospective study, 176 children with were enrolled from January 2005 to December 2006. Appropriate screening and definitive tests performed establish etiology stature.Celiac disease (CD) emerged as single most common (15.3%) cause stature, followed by various endocrine disorders. It was interesting note that none CD patients presented gastrointestinal symptoms.All should be screened for...
Abstract The introduction of vaccines has inspired new hope in the battle against SARS-CoV-2. However, emergence viral variants, absence potent antivirals, left world struggling with uncertain nature this disease. Antibodies currently represent strongest correlate immunity COVID-19, thus we profiled earliest humoral signatures a large cohort severe and asymptomatic COVID-19 individuals. While SARS-CoV-2-specific immune response evolved rapidly survivors non-survivors exhibited blunted...