A5068587640- Nanoparticles: synthesis and applications
- Essential Oils and Antimicrobial Activity
- Nanoparticle-Based Drug Delivery
- Graphene and Nanomaterials Applications
- Nanomaterials for catalytic reactions
- Nanotechnology research and applications
- Antifungal resistance and susceptibility
- Wound Healing and Treatments
- Pharmacological Effects of Natural Compounds
- Synthesis and Characterization of Heterocyclic Compounds
- Polysaccharides and Plant Cell Walls
- Mitochondrial Function and Pathology
- 3D Printing in Biomedical Research
- Phytochemicals and Antioxidant Activities
- Bee Products Chemical Analysis
- Photoreceptor and optogenetics research
- Immunotherapy and Immune Responses
- Traumatic Ocular and Foreign Body Injuries
- Circadian rhythm and melatonin
- Medicinal Plants and Neuroprotection
- Antimicrobial agents and applications
- Phytochemistry and Biological Activities
- Disaster Response and Management
- Invertebrate Immune Response Mechanisms
- Fungal Biology and Applications
National Academies of Sciences, Engineering, and Medicine
2023-2025
Walter Reed Army Institute of Research
2023-2025
Karunya University
2020-2024
Boston University
2020-2022
Background/Objectives: Blast-induced traumatic ocular injuries (bTOI) pose a significant risk to military and civilian populations, often leading visual impairment or blindness. Retina, the innermost layer of tissue consisting photoreceptor glial cells, is highly susceptible blast injuries. Despite its prevalence, molecular mechanisms underlying retinal damage following bTOI remain poorly understood, hindering development targeted therapies. Melatonin, neuroprotective indoleamine with...
Palmyra Palm (Borassus flabellifer Linn) is a native tree with various ecological, medicinal, economic, and sociological benefits from Asian countries. tree-based self-reliant lifestyle Eco-friendly community living which leads to sustainable development can be called palmyra culture. For each component, the most beneficial species that has economic medicinal value could sustain adverse climatic conditions resist natural calamities. Non-edible, edible, add-based uses widely categorized into...
Mucorales species cause debilitating, life-threatening sinopulmonary diseases in immunocompromised patients and penetrating wounds trauma victims. Common antifungal agents against mucormycosis have significant toxicity are often ineffective. To evaluate treatments mucormycosis, sporangiospores typically used for vitro assays pre-clinical animal models of pulmonary infections. However, clinical cases wound caused by traumatic inoculation, hyphal elements found soil likely the form inoculated...
Wound-invasive fungal diseases (WIFDs), especially mucormycosis, have emerged as life-threatening infections during recent military combat operations. Many combat-relevant pathogens are refractory to current antifungal therapy. Therefore, animal models of WIFDs urgently needed investigate new therapeutic solutions. Our study establishes murine wound mucormycosis using
This is the first study to report green synthesis of Lobelia trigona Roxb-mediated silver nanoparticles (LTAgNPs). The optical and structural properties synthesised LTAgNPs were analysed using ultraviolet-visible spectroscopy, scanning electron microscopy, Fourier transform infrared, dynamic light scattering energy dispersive X-ray. LTAgNps evaluated for their anti-bacterial anti-fungal against 18 pathogens exhibited significant inhibition all strains tested. had potential scavenging effects...
This is the first study to evaluate topical application of Lobelia alsinoides Lam (LT) ethanolic extract on burns in rats. A deep third-degree burn wound was inflicted adult male Wistar rats and were dressed daily with a ointment formulation (Patent filed) comprising (5% 10% w/w). The had noteworthy contraction quicker eschar removal w/w LT-treated groups followed by 5% treated comparing commonly prescribed (SilverexTM containing 1% Silver sulfadiazine). Histopathological analysis showed...
ABSTRACT Introduction Extensive trauma, commonly seen in wounded military Service Members, often leads to a severe sterile inflammation termed systemic inflammatory response syndrome (SIRS), which can progress multiple organ dysfunction (MODS) and death. MODS is serious threat historically causing 10% of all deaths trauma admissions at forward deployed combat hospital. The importance this problem will be exacerbated large-scale operations, evacuation delayed care complex injuries lower...
ABSTRACT Introduction Bloodstream infections are a significant threat to soldiers wounded in combat and contribute preventable deaths. Novel combination therapies that can be delivered on the battlefield or lower roles of care urgently needed address bloodstream infection among military personnel. In this manuscript, we tested antibacterial capability silver ions (Ag+), with long-appreciated properties, against ESKAPEE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae,...