A5101884843- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Stress Responses and Cortisol
- Neuroscience and Neuropharmacology Research
- Virus-based gene therapy research
- Hedgehog Signaling Pathway Studies
- Pharmacological Receptor Mechanisms and Effects
- Neuroendocrine regulation and behavior
- melanin and skin pigmentation
- Ion channel regulation and function
- Amino Acid Enzymes and Metabolism
- Protein Kinase Regulation and GTPase Signaling
- Genomics and Chromatin Dynamics
- Retinoids in leukemia and cellular processes
- CRISPR and Genetic Engineering
- Cancer Treatment and Pharmacology
- Cell death mechanisms and regulation
- Retinal Development and Disorders
- Chromosomal and Genetic Variations
- Drug Transport and Resistance Mechanisms
- Reproductive biology and impacts on aquatic species
- Estrogen and related hormone effects
- Aquaculture disease management and microbiota
- Occupational and environmental lung diseases
- Microtubule and mitosis dynamics
Takara (United States)
2020-2023
Hôpital Corentin-Celton
2022
North Carolina Agricultural and Technical State University
2010-2022
SpaceX (United States)
2021-2022
Conservatoire National des Arts et Métiers
2019-2022
Université d'Artois
2020
Nanyang Technological University
2019
Université Côte d'Azur
2004-2017
Bowdoin College
2017
Inserm
1983-2017
Wnt/beta-catenin signaling has been proven to play a central role in bone biology. Unexpectedly, the Wnt antagonist Dkk2 is required for terminal osteoblast differentiation and mineralized matrix formation. We show that Dkk1, unlike Dkk2, negatively regulates formation.The co-receptor LRP5 critical regulator of mass. Dickkopf (Dkk) proteins act as natural antagonists by bridging LRP5/6 Kremen, inducing internalization complex. are thus expected regulation However, deficiency results...
Prostaglandin (PG) production by human breast cancers was investigated in 91 lesions selected so that the distribution of histologic type similar to general population mammary carcinomas. With regard shape characteristics tumors, PG higher classified T1 and T2 than T3 T4 (T-classification is based on extent tumor as graded International Union Against Cancer), tumors exhibiting a high cellularity with low cell density which cells were still adherent each other. A associated presence...
Daily synchronous rhythms of cell division at the tissue or organism level are observed in many species and suggest that circadian clock cycle oscillators coupled. For mammals, despite known mechanistic interactions, effect such coupling on progression, hence its biological relevance, is not understood. In particular, we do know how temporal organization single-cell produces this daily rhythm level. Here use multispectral imaging single live cells, computational methods, mathematical...
SARS-CoV-2 mRNA vaccines confer robust protection against COVID-19, but the emergence of variants has generated concerns regarding protective efficacy currently approved vaccines, which lose neutralizing potency some variants. Emerging data suggest that antibody functions beyond neutralization may contribute to from disease, little is known about effector functions. Here, we profiled binding and functional capacity convalescent antibodies Moderna mRNA-1273 COVID-19 vaccine-induced across...
CLIP-170 is a plus-end tracking protein which may act as an anticatastrophe factor. It has been proposed to mediate the association of dynein/dynactin microtubule (MT) plus ends, and it also binds kinetochores in dynein/dynactin-dependent fashion, both via its C-terminal domain. This domain contains two zinc finger motifs (proximal distal), are hypothesized protein-protein interactions. LIS1, implicated brain development, acts several processes mediated by pathway interacting with dynein...
A unique feature of SW480 and SW620 colon carcinoma cell lines is that they are derived from primary secondary tumours resected a single patient. As such, may represent valuable resource for examining genetic changes late in cancer progression. In order to verify this, both have been characterized determine whether phenotypic differences retained despite long-term culture vitro. The tumour-derived cells an epithelioid morphology vitro, while metastasis-derived fibroblast-like appearance....
Fragile X syndrome, the most frequent form of inherited mental retardation, is due to absence Mental Retardation Protein (FMRP), an RNA-binding protein involved in several steps RNA metabolism. To date, two motifs have been found mediate FMRP/RNA interaction, G-quartet and "kissing complex," which both induce translational repression presence FMRP. We show here a new role for FMRP as positive modulator translation. specifically binds Superoxide Dismutase 1 (Sod1) mRNA with high affinity...
Preexisting cross-coronavirus immunity influences the early development of SARS-CoV-2 humoral after COVID-19.
Avian erythroblastosis virus (AEV) contains two distinct oncogenes, erb A and B. The B oncogene, which is homologous to a portion of the epidermal growth factor receptor, related src family oncogenes efficiently transforms erythroblasts, whereas potentiates effects by blocking differentiation erythroblasts at an immature stage. This "potentiator" was sequenced; amino acid sequence deduced from it clearly different sequences other known oncogene products carbonic anhydrases. These enzymes...
Both the epidermal growth factor receptor (EGFR) and protein kinase C (PKC) play important roles in glioblastoma invasive growth; however, interaction between EGFR PKC is not well characterized glioblastomas. Treatment with EGF stimulated global phosphorylation of at Tyr845, Tyr992, Tyr1068, Tyr1045 cell lines (U-1242 MG U-87 MG). Interestingly, phorbol 12-myristate 13-acetate (PMA) only Tyr1068 two lines. Phosphorylation was detected normal human astrocytes treated ester. PMA-induced...
The translocation found in acute promyelocytic leukemia rearranges the gene (PML) on chromosome 15 with retinoic acid receptor alpha (RARalpha) 17. This yields a fusion transcript, PML/RARalpha, transcription factor reported dominant negative functions absence of hormone. Clinical remissions induced all-trans (RA) treatment are linked to PML/RARalpha expression leukemic cells. To evaluate role myelopoiesis, transgenic mice expressing were engineered. A full-length cDNA driven by CD11b...
After differential screening of a cDNA library constructed from quail neuroretina cells (QNR) infected with the v-myc-containing avian retrovirus MC29, we have isolated clone, Pax-QNR, homologous to murine Pax-6, which is mutated in autosomal dominant mutation small eye mice and disorder aniridia humans. Here report characterization Pax-QNR proteins expressed neuroretina. From bacterially peptides, obtained rabbit antisera directed against different domains protein: paired domain (serum 11),...
Animal behavioural models of psychiatric disorders cannot exactly simulate human psychopathology, but they can be used to evaluate the changes induced by drugs and suggest hypotheses about functions CNS its involvement in disorders. This should lead a more heuristic classification psychotropic clarification their therapeutic possibilities. The following animal aspects depressive are sensitive antidepressant effects drugs. (i) forced swimming test: described as ‘behavioural despair‘ on...