A5000906257- Phytochemistry and Biological Activities
- Pharmacological Effects of Natural Compounds
- Phytochemistry and biological activities of Ficus species
- Natural product bioactivities and synthesis
- Natural Antidiabetic Agents Studies
- Toxin Mechanisms and Immunotoxins
- Traditional and Medicinal Uses of Annonaceae
- Glioma Diagnosis and Treatment
- Neuroscience and Neuropharmacology Research
- Biological and pharmacological studies of plants
- Chemical synthesis and alkaloids
- Herbal Medicine Research Studies
- Cancer Mechanisms and Therapy
- Ziziphus Jujuba Studies and Applications
- Natural Compound Pharmacology Studies
- Ethnobotanical and Medicinal Plants Studies
- Alkaloids: synthesis and pharmacology
- Melanoma and MAPK Pathways
- Ubiquitin and proteasome pathways
- Biochemical Analysis and Sensing Techniques
- Neurotransmitter Receptor Influence on Behavior
- Microbial Metabolites in Food Biotechnology
- Receptor Mechanisms and Signaling
- Cell death mechanisms and regulation
- Olfactory and Sensory Function Studies
Cedarville University
2016-2024
University of Nigeria
2004-2024
University of Virginia
2003-2013
National Institute for Pharmaceutical Research and Development
1998-2012
University of Virginia Health System
2004-2010
Hacettepe University
2010
Turkish Thoracic Society
2010
Obafemi Awolowo University
1997
South Thames College
1976
Emerging studies have identified microRNAs (miRNAs) as possible therapeutic tools for the treatment of glioma, most aggressive brain tumor. Their important targets in this tumor are not well understood. We recently found that Notch pathway is a target miRNA-326. Ectopic expression miRNA-326 glioma and stem cells induced their apoptosis reduced metabolic activity. Computational gene prediction revealed pyruvate kinase type M2 (PKM2) another PKM2 has been shown to play key role cancer cell...
Abstract The antidiarrhoeal effects of the aqueous root extract Terminalia avicennoides were evaluated in rodents. Studies carried out on isolated rabbit jejunum, gastrointestinal motility vivo and castor oil‐induced diarrhoea mice. results revealed that exhibited a concentration‐dependent inhibition spontaneous pendular movement jejunum attenuated acetylcholine induced contractions. (100, 200 400 mg/kg) also caused dose‐dependent decrease transit markedly protected mice against diarrhoea....
Both the epidermal growth factor receptor (EGFR) and protein kinase C (PKC) play important roles in glioblastoma invasive growth; however, interaction between EGFR PKC is not well characterized glioblastomas. Treatment with EGF stimulated global phosphorylation of at Tyr845, Tyr992, Tyr1068, Tyr1045 cell lines (U-1242 MG U-87 MG). Interestingly, phorbol 12-myristate 13-acetate (PMA) only Tyr1068 two lines. Phosphorylation was detected normal human astrocytes treated ester. PMA-induced...
Glioblastomas are a subtype of gliomas, which the most aggressive and deadly form brain tumours. The epidermal growth factor receptor (EGFR) is over-expressed amplified in glioblastomas. Luteolin common bioflavonoid found variety fruits vegetables. aim this study was to explore molecular biological effects luteolin on EGF-induced cell proliferation potential induce apoptosis glioblastoma cells. In vitro viability assays demonstrated that decreased presence or absence EGF. Immunoblots...
AIM: Protein kinase-C (PKC) and NF-kappaB are involved in cell survival, proliferation, migration radioresistance glioblastoma multiforme (GBM).We sought to determine the interaction between PKC pathways. MATERIAL METHODS:The activation of by α δ was assessed Western blotting after stimulation with Phorbol 12-Myristate 13-Acetate (PMA).Gene silencing , NF-kappaB/p65 siRNA interference utilized evaluate their roles NF-kB proliferation. RESULTS:PMA induced phosphorylation α.Gene against...
Abstract Objectives Glioblastoma (GBM) is highly proliferative, infiltrative, malignant and the most deadly form of brain tumour. The epidermal growth factor receptor (EGFR) overexpressed, amplified mutated in GBM has been shown to play key important roles proliferation, survival this goal our study was investigate antiproliferative, apoptotic molecular effects apigenin GBM. Methods Proliferation viability tests were carried out using trypan blue exclusion, MTT lactate dehydrogenase (LDH)...
Abstract Aggressive and infiltrative invasion is one of the hallmarks glioblastoma. Low-density lipoprotein receptor–related protein (LRP) expressed by glioblastoma, but role this receptor in astrocytic tumor remains poorly understood. We show that activation kinase C-α (PKC-α) phosphorylated down-regulated LRP expression. Pretreatment cells with PKC inhibitors, phosphoinositide 3-kinase (PI3K) inhibitor, PKC-α small interfering RNA (siRNA), short hairpin abrogated phorbol 12-myristate...