A5071712135- Phytochemistry and Biological Activities
- Phytochemistry and biological activities of Ficus species
- Neuroscience and Neuropharmacology Research
- Natural Antidiabetic Agents Studies
- Medicinal Plants and Neuroprotection
- Ethnobotanical and Medicinal Plants Studies
- Ginger and Zingiberaceae research
- Pharmacological Effects of Natural Compounds
- Biological and pharmacological studies of plants
- Medicinal Plant Extracts Effects
- Phytochemistry and Bioactive Compounds
- Ziziphus Jujuba Studies and Applications
- Natural product bioactivities and synthesis
- Epilepsy research and treatment
- Alkaloids: synthesis and pharmacology
- Neurotransmitter Receptor Influence on Behavior
- Olfactory and Sensory Function Studies
- Traditional and Medicinal Uses of Annonaceae
- Receptor Mechanisms and Signaling
- Tryptophan and brain disorders
- African Botany and Ecology Studies
- Treatment of Major Depression
- Drug-Induced Hepatotoxicity and Protection
- Chromatography in Natural Products
- Pharmacological Effects of Medicinal Plants
Kaduna State University
2014-2024
National Institute for Pharmaceutical Research and Development
2008-2021
Ahmadu Bello University
2011-2020
Otto-von-Guericke University Magdeburg
2014-2016
University of Otago
2008
Wound healing agents support the natural process, reduce trauma and likelihood of secondary infections hasten wound closure. The activities water in oil cream methanol extract Hibiscus sabdariffa L. (Malvaceae) was evaluated rats with superficial skin excision wounds. Antibacterial against Pseudomonas aeroginosa, Staphylococcus aureus Echerichia coli were determined. total flavonoid content, antioxidant properties thin layer chromatographic fingerprints also evaluated. demonstrated a content...
Crossopteryx febrifuga (Afzel.) Benth. (Rubiaceae) widely used in Northern Nigeria for management of trypanosomiasis, malaria and pain, has been previously shown to possess analgesic, anti-pyretic anti-plasmodial effects. In the present study, acute sub-acute toxicity studies methanolic stem bark extract of C. febrifuga were carried out rats. Using modified lorkes (1983) method. sub 4 groups 5 rats per group were used. Group 1 (control) received normal 10 ml saline/kg body weight while 2, 3...
Preparations of Crossopteryx febrifuga have been used in traditional medicine for treatment pain and malaria many years their efficacies are widely acclaimed among the Hausa communities northern Nigeria. The methanolic extract C. was evaluated analgesic, anti-inflammatory, antipyretic anti-plasmodial activities rodents. significantly diminished acetic acidinduced writhes mice increased threshold rats dose-dependently. It also demonstrated significant anti-plasmodial, anti-inflammatory a...
Carissa edulis Vahl (Apocynaceae) is used in Nigerian folk medicine to manage a plethora of diseases including epilepsy, cancer, and inflammation; its efficacy widely acclaimed among communities northern Nigeria.This study establishes anticonvulsant activities aqueous fraction ethanol root bark extract (RAF) sub-fractions (S1 S2) animal models.We evaluated the acute toxicity RAF, S1 S2, activity using pentylenetetrazole (PTZ), picrotoxin, strychnine, N-methyl-d-aspartate (NMDA), isoniazid...
Melissa officinalis L. is used in traditional European and Iranian folk medicines to treat a plethora of neurological diseases including epilepsy. We utilized the vitro vivo models epilepsy probe anticonvulsant potentials essential oil from M. (MO) gain insight into scientific basis for its applications medicine management convulsive disorders. MO was evaluated effects on maximal electroshock (MES) pentylenetetrazole (PTZ) -induced seizures mice, 4-aminopyridine (4-AP)-brain slice model...
ABSTRACT The methanolic extract of Ficus platyphylla Del.-Holl. stem bark was investigated for anti-inflammatory and anti-nociceptive activities. activity tested against egg albumin-induced edema, while the analgesic effects were studied using acetic acid-induced writhing in mice formalin test mice. results revealed that aqueous possess significant, dose dependent effects. also inhibited pain caused by acid reduced episodes induced formalin. intraperitoneal LD50 2000 mg/kg.
Decoctions of the root plant Neorautanenia mitis. (A. Rich) Verde (Papilonaceae) are commonly employed ethnomedicinally in treatment neuropsychiatric disorders and some other conditions. The central inhibitory effects methanol extract N. (5–20 mg/kg) were therefore investigated mice rats to provide scientific evidence for these claims. Activities studied on pentobarbital hypnosis rats, spontaneous motor activity (SMA), exploratory activity, rota-rod performance (motor coordination),...
Liver cancer is the most common among males in Africa. The disease has a poor prognosis and its treatment associated with toxicity resistance. For this reason, numerous herbal combinations are being subjected to anticancer screening circumvent shortcomings of conventional drugs. In current study,
The neuropharmacological effects of the aqueous extract Hibiscus sabdariffa (HS) calyx were studied in rodents. HS (100, 200 and 400 mg/kg, i.p.) caused a remarkable dose-dependent decrease spontaneous motor activity mice increased duration pentobarbital (40 induced sleep rats. (100-400 significantly reduced exploratory behaviour mice. inhibited intensity apomorphine (1 s.c.) stereotypic attenuated climbing dose-dependently. Similarly, chlorpromazine (3 blocked stereotype significantly....