A5003075739- Virus-based gene therapy research
- Hydrology and Watershed Management Studies
- Flood Risk Assessment and Management
- Advanced Chemical Physics Studies
- Atomic and Molecular Physics
- Environmental and Agricultural Sciences
- Cancer Research and Treatments
- Precipitation Measurement and Analysis
- Advanced NMR Techniques and Applications
- Viral Infectious Diseases and Gene Expression in Insects
- Poxvirus research and outbreaks
- Environmental Changes in China
- CAR-T cell therapy research
- Anodic Oxide Films and Nanostructures
- interferon and immune responses
- Meteorological Phenomena and Simulations
- Spectroscopy and Quantum Chemical Studies
- Hydrology and Drought Analysis
- Cryospheric studies and observations
- Soil erosion and sediment transport
- NMR spectroscopy and applications
- Remote Sensing and Land Use
- Climate variability and models
- Free Radicals and Antioxidants
- Molecular Spectroscopy and Structure
Hohai University
2004-2024
Hunan University of Technology
2023-2024
Aptose Biosciences (Canada)
2024
State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering
2008-2023
Wuhan University of Science and Technology
2022
Ottawa Hospital
2011-2019
Ottawa Hospital Research Institute
2011-2019
Q Therapeutics (United States)
2019
Memorial Sloan Kettering Cancer Center
2019
University of Oklahoma
2008-2017
Two standard Tropical Rainfall Measuring Mission (TRMM) Multisatellite Precipitation Analysis (TMPA) products, 3B42RT and 3B42V6, were quantitatively evaluated in the Laohahe basin, China, located within TMPA product latitude band (50°NS) but beyond inclined TRMM satellite (36°NS). In general, direct comparison of rainfall estimates to collocated rain gauges from 2000 2005 show that spatial temporal characteristics over region are well captured by 3B42V6 estimates. Except for a few months...
Floods are among the most catastrophic natural disasters around globe impacting human lives and infrastructure. Implementation of a flood prediction system can potentially help mitigate flood-induced hazards. Such typically requires implementation calibration hydrologic model using in situ observations (i.e., rain stream gauges). Recently, satellite remote sensing data have emerged as viable alternative or supplement to due their availability over vast ungauged regions. The focus this study...
Oncolytic viruses are generally designed to be cancer selective on the basis of a single genetic mutation. JX-594 is thymidine kinase (TK) gene-inactivated oncolytic vaccinia virus expressing granulocyte-macrophage colony-stimulating factor (GM-CSF) and lac-Z transgenes that destroy cells through replication-dependent cell lysis stimulation antitumoral immunity. has demonstrated favorable safety profile reproducible tumor necrosis in variety solid types clinical trials. However, mechanism(s)...
The Coupled Routing and Excess STorage model (CREST, jointly developed by the University of Oklahoma NASA SERVIR) is a distributed hydrological to simulate spatial temporal variation land surface, subsurface water fluxes storages cell-to-cell simulation. CREST's distinguishing characteristics include: (1) rainfall–runoff generation routing; (2) coupled runoff routing via three feedback mechanisms; (3) representation sub-grid cell variability soil moisture storage capacity (via linear...
Oncolytic viruses capable of tumor-selective replication and cytolysis have shown early promise as cancer therapeutics. However, the host immune system remains a significant obstacle to effective systemic administration virus in clinical setting. Here, we demonstrate severe negative impact adaptive response on delivery oncolytic vesicular stomatitis (VSV) an immune-competent murine tumor model, effect mediated primarily by neutralization injected virions circulating antibodies. We show that...
A simple formalism for the evaluation of 〈S2〉 in terms two-particle density matrix is presented. The implementation restricted open-shell Hartree–Fock (ROHF), unrestricted HF (UHF) and functional (DFT) based theories discussed. Rules governing nonzero S2 elements UHF methods are Further examples given several atomic radical systems from very models.
Abstract In this study we developed an impact factor formula (IFF) to quantitatively attribute separately the impacts of climate change and local human activities on hydrological response (i.e. run‐off) in a sub‐basin Yellow River for period 1950–2000. Using daily climatic data, first calibrated verified variable infiltration capacity (VIC) model baseline 1955–1970. Then basin's natural run‐off following three decades (1971–2000) using VIC without considering impacts, as is benchmarked by...
Abstract This study evaluates rainfall estimates from the Next Generation Weather Radar (NEXRAD), operational rain gauges, Tropical Rainfall Measuring Mission (TRMM) Multisatellite Precipitation Analysis (TMPA), and Estimation Remotely Sensed Information using Artificial Neural Networks Cloud Classification System (PERSIANN-CCS) in context as inputs to a calibrated, distributed hydrologic model. A high-density Micronet of gauges on 342-km 2 Ft. Cobb basin Oklahoma was used reference...
This study characterizes the ability of novel oncolytic rhabdoviruses (Maraba MG1) to boost natural killer (NK) cell activity. Our results demonstrate that MG1 activates NK cells via direct infection and maturation conventional dendritic cells. Using depletion ablation studies in vivo, we established both are required for efficacy. We further explored efficacy attenuated (nonreplicating MG1-UV(2min) single-cycle replicating MG1-Gless) demonstrated these viruses activate cells, although a...
The purpose of this study was to investigate the oncolytic potential recombinant, granulocyte macrophage colony-stimulating factor (GM-CSF)-expressing vaccinia virus (VV) JX-594 in experimental malignant glioma (MGs) vitro and immunocompetent rodent models. We have found that killed all MG cell lines tested vitro. Intratumoral (i.t.) administration significantly inhibited tumor growth prolonged survival rats-bearing RG2 intracranial (i.c.) tumors mice-bearing GL261 brain tumors. Combination...
Oncolytic viruses pose many questions in their use cancer therapy. In this study, we assessed the potential of mpJX-594 (mouse-prototype JX-594), a replication-competent vaccinia virus administered by intravenous injection, to target tumor vasculature, produce immune activation and cell killing more widespread than infection, suppress invasion metastasis. These actions were examined RIP-Tag2 transgenic mice with pancreatic neuroendocrine tumors that developed spontaneously progressed as...
The total, inelastic and elastic intensities for x-ray high energy electron scattering from the ten-electron molecules CH4, NH3, H2O, HF have been calculated with configuration interaction wave functions. probability density of interelectronic distance or radial intracule is extracted intensities. importance basis sets, chemical binding, correlation to scattered has examined. It found that predicted correlated functions agree well experiment. Based on pair distribution, exchange holes in...
The solvent dependence of the tautomeric equilibria 2-, 3- and 4-hydroxypyridines is investigated by means self-consistent reaction field (SCRF) theory. equilibrium constants (KT) in cyclohexane, chloroform, acetonitrile are predicted at both Hartree−Fock (HF) second-order Møller−Plesset perturbation theory (MP2) levels. It found that log KT linearly dependent upon polarity as measured Kosower Z parameter, agreement with earlier experimental findings. Based on this relation, to be 1.72,...
Abstract Rainfall products from radar, satellite, rain gauges, and combinations have been evaluated for a season of record rainfall in heavily instrumented study domain Oklahoma. Algorithm performance is terms spatial scale, temporal intensity. Results this will help users to understand their errors. Moreover, it intended that developers algorithms use the results presented herein optimize contribution available sensors yield most skillful multisensor products.
Renewal of nongermative epithelia is poorly understood. The novel mitogen “lacritin” apically secreted by several epithelia. We tested 17 different cell types and discovered that lacritin preferentially mitogenic or prosecretory for those normally contact during its glandular outward flow. Mitogenesis dependent on lacritin's C-terminal domain, which can form an α-helix with a hydrophobic face, as per VEGF's PTHLP's respective dimerization receptor-binding domain. Lacritin targets downstream...
The head region of the Yellow River is key area where climate change would affect hydrological process, since it in a high elevation and cold area. Temperature precipitation are two important meteorologic factors influencing process. In this study, runoff was evaluated as result process an evaluation response to made. Data derived from results seven general circulation models (GCMs) under intergovernmental panel on scenarios (A2 B2) were used future scenarios. First, factual analyzed...
Background Genetic manipulation of poxvirus genomes through attenuation, or insertion therapeutic genes has led to a number vector candidates for the treatment variety human diseases. The development recombinant poxviruses often involves genomic selectable marker purification and selection purposes. use however inevitably results in that contains unwanted genetic information no value. Methodology/Principal Findings Here we describe an improved strategy allows creation marker-free any...
We have applied a scalable and extensible geo‐fluid model (SEGMENT) that considers soil mechanics, vegetation transpiration root mechanical reinforcement, hydrological processes to simulate two dimensional maps of the landslides occurrence following 2008 Wenchuan earthquake. Modeled locations areas generally agree with observations. The suggests potential energy earth was lowered by 1.52 × 10 15 J these landslides. With this, destroyed transfer ∼235 Tg C dead respiring pool transforms 5.54...
To sequence and comprehensively analyze human mouse lacrimal gland transcriptomes as part of the NEIBank project.cDNA libraries generated from normal glands were sequenced analyzed by PHRED, RepeatMasker, BLAST, GRIST. Human "lacrimal-preferred genes" putative gene regulatory elements respectively identified in UniGene ConSite, clustering was chromosomal mapping. "Hypothetical proteins," keyword search, verified genomic alignment queried Conserved Domain database GEO Profiles.The top six...