A5115592693- Parathyroid Disorders and Treatments
- Heart Rate Variability and Autonomic Control
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Endometriosis Research and Treatment
- Ovarian function and disorders
- Genetic Syndromes and Imprinting
- Medical Imaging and Pathology Studies
- Gestational Diabetes Research and Management
- Assisted Reproductive Technology and Twin Pregnancy
- Dialysis and Renal Disease Management
- Connective tissue disorders research
- Blood Pressure and Hypertension Studies
- Liver Disease Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Streptococcal Infections and Treatments
- Diet and metabolism studies
- Viral gastroenteritis research and epidemiology
- Viral Infections and Outbreaks Research
- Reproductive System and Pregnancy
- Traditional Chinese Medicine Studies
- Uterine Myomas and Treatments
- EEG and Brain-Computer Interfaces
- Liver Disease and Transplantation
- Regulation of Appetite and Obesity
Jiangsu Province Hospital
2013-2025
Nanjing Medical University
2012-2025
Tianjin Medical University General Hospital
2023-2025
Tianjin Medical University
2025
Tianjin University
2020-2025
Central Hospital Affiliated to Shenyang Medical College
2025
Huashan Hospital
2023-2024
Affiliated Hospital of Guizhou Medical University
2024
PLA Information Engineering University
2024
Fudan University
2023-2024
Angiotensin-converting enzyme 2 (ACE2) plays an important role in the development of essential hypertension (EH). The aim this study was to investigate relationship ACE2 gene polymorphisms and enzymatic activity with EH northeastern Chinese Han population. 34 single-nucleotide polymorphism (SNP) loci were detected 1024 patients 956 normotensive (NT) controls by Sequenom Mass-ARRAY RS1000. Five SNPs (rs1514283, rs4646155, rs4646176, rs2285666, rs879922) determined significantly associate...
Pharmaceutical cocrystal has gained increasing interest due to its ability modify various physicochemical properties of hydrophobic drugs, especially solubility and dissolution. The temporarily generated supersaturation during the dissolution cocrystals, usually called "spring parachute" effect, would favor oral absorption poorly soluble drugs. In this study, biopharmaceutics classification system II drug ibuprofen (IBU) was cocrystallized with nicotinamide (NIC) by slow solvent evaporation....
With the outbreak of recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 2019, coronaviruses have become a global research hotspot field virology. Coronaviruses mainly cause and digestive tract diseases, several are responsible for porcine diarrhea, such as epidemic diarrhea virus (PEDV), deltacoronavirus (PDCoV), emerging swine (SADS-CoV). Those viruses caused huge economic losses considered potential public health threats. Porcine torovirus (PToV) coronaviruses, sharing...
The harm of air pollution to public health has become a research hotspot, especially atmospheric fine-particulate matter (PM2.5). In recent years, epidemiological investigations have confirmed that PM2.5 is closely related chronic kidney disease and membranous nephropathy Basic demonstrated an impact on the normal function kidneys through accumulation in kidney, endothelial dysfunction, abnormal renin-angiotensin system, immune complex deposition. Moreover, mechanism damage involves...
Brain ischemia and reperfusion (I/R) injury may lead to a poor prognosis for ischemic stroke, which could be alleviated by antioxidants with diminished oxidative stress. Betaine is natural nutrient found in beetroot seafood improve cognitive performance the elderly. The present study investigated whether betaine protect brain from I/R injury. Results showed that treatment reduce H2O2-induced cell death PC12 line. Pretreatment reduced infarct volume neuronal apoptosis rat model induced 2-h...
Background/Aims: Cisplatin is widely used to treat malignancies. However, its major limitation the development of dose-dependent nephrotoxicity. The precise mechanisms cisplatin-induced kidney damage remain unclear. Previous study demonstrated central role mitochondrial ROS (mtROS) in pathogenesis cisplatin purpose this was explore mechanism mtROS regulation Methods: p53, MnSOD and p66shc were detected at mRNA protein levels by qPCR western blot HK2 cells. determined DCFDA MitoSOX staining....
The current coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome 2 (SARS-CoV-2), highlights major gaps in our knowledge on the prevention control and cross-species transmission mechanisms of animal coronaviruses. Transmissible gastroenteritis virus (TGEV), porcine epidemic diarrhea (PEDV), delta (PDCoV) are three common swine coronaviruses have similar clinical features. In absence effective treatments, they led to significant economic losses industry...
"Glutamine addiction" is a unique feature of triple negative breast cancer (TNBC), which has higher demand for glutamine and more susceptible to depletion. Glutamine can be hydrolyzed glutamate by glutaminase (GLS) synthesis glutathione (GSH), an important downstream metabolic pathways in accelerating TNBC proliferation. Consequently, intervention suggests potential therapeutic effects against TNBC. However, the GLS inhibitors are hindered resistance their own instability insolubility....
Both EGFR and VEGFR-2 play a critical role in tumor growth, angiogenesis metastasis, targeting simultaneously represents promising approach to cancer treatment. In this work, series of novel quinazoline- thiourea-containing sorafenib analogs (10a-v) were designed synthesized as dual TK inhibitors. Their vitro enzymatic inhibitory activities against VEGFR-2, antiproliferative HCT-116, MCF-7 B16 cell lines evaluated described. Most the compounds showed potent both kinases. Compounds 10b 10q...
Background Acute brain ischaemia elicits pronounced inflammation, which aggravates neural injury. However, the mechanisms governing resolution of acute neuroinflammation remain poorly understood. In contrast to regulatory T and B cells, group 2 innate lymphoid cells (ILC2s) are immunoregulatory that can be swiftly mobilised without antigen presentation; whether how these ILC2s participate in central nervous system inflammation following is still unknown. Methods Leveraging tissues from...
Introduction As a systemic autoimmune disorder, the prognosis of rheumatoid arthritis (RA) is intricately linked to inflammation. This study aimed investigate association between advanced lung cancer inflammation index (ALI), comprehensive indicator combined with nutritional status, and all-cause cardiovascular mortality among patients diagnosed RA. Methods The 2,305 RA from NHANES (2001–2018) included in analysis were categorized into three groups according ALI tertiles. Weighted...
Previous studies have validated that different balance tasks induce cortical responses, which are key indexes of assessment. Assessing is crucial for stroke survivors to prevent falls and improve rehabilitation outcomes. However, it was unclear whether these may affect the assessment, particularly regarding relationship between task difficulty corresponding responses involved in control. Therefore, we sought explore effects challenge-level on Eighteen participants with thirteen healthy...
The advance in e-commerce has provided firms with more options when designing their channel structures. rise of “beyond profit” managerial doctrine also added complexity to design. Extending the literature distribution channels that focuses on for-profit firms, this paper develops a stylized model examine design problem for socially responsible manufacturer who pursues dual-purpose objective–the values both profit and consumer surplus. We compare three structures: direct selling...
Our previous studies demonstrated that activated T cells accumulate in perihematomal regions following intracerebral hemorrhage (ICH) and exacerbate hemorrhagic brain injury. In the present study, we aimed to explore mechanisms underlying brain-infiltrating cell activation associated pathophysiological effects neurological outcomes ICH. We employed standardized collagenase injection-induced autologous blood injection models of ICH male C57BL/6J mice. receptor (TCR) activation, immune...
Intradialytic hypotension (IDH) is a prevalent complication during hemodialysis (HD). However, conventional predictive models are imperfect due to multifaceted etiologies underlying IDH. This study enrolled 201 patients undergoing maintenance HD across two centers. Seventy percent of the patient cohort was randomly allocated training (n = 136), while remaining 30% formed validation 65). IDH defined as reduction in systolic blood pressure (SBP) ≥20 mmHg or mean arterial (MAP) ≥10 mmHg....
Objective The current study aimed to investigate the role of myocardial infarction-associated transcript (MIAT)/microRNA-326 (miR-326) axis in regulating migration vascular smooth muscle cells (VSMCs) during progression atherosclerosis (AS). Methods Bioinformatic analysis MIAT and miR-326 two AS-related GEO datasets was performed via online web tool GEO2R. expression 46 paired plasma samples oxidized low-density lipoprotein (ox-LDL)-treated VSMCs analysed RT–qPCR. Western blot used determine...