A5077315278- MicroRNA in disease regulation
- Osteoarthritis Treatment and Mechanisms
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- Knee injuries and reconstruction techniques
- Extracellular vesicles in disease
- Air Quality and Health Impacts
- Bone Tissue Engineering Materials
- Sleep and Wakefulness Research
- Tissue Engineering and Regenerative Medicine
- Health disparities and outcomes
- Effects and risks of endocrine disrupting chemicals
- Cancer-related molecular mechanisms research
- Global Health Care Issues
- Climate Change and Health Impacts
- Biomarkers in Disease Mechanisms
- Iron Metabolism and Disorders
- Psychological Well-being and Life Satisfaction
- Sleep and related disorders
- Epigenetics and DNA Methylation
- Adipose Tissue and Metabolism
- Acne and Rosacea Treatments and Effects
- Youth Substance Use and School Attendance
- Muscle and Compartmental Disorders
- Calcium signaling and nucleotide metabolism
Dalian Medical University
2019-2025
Nankai University
2022-2023
Chinese PLA General Hospital
2022-2023
Kunming Medical University
2021-2023
First Affiliated Hospital of Kunming Medical University
2023
Beijing Haidian Hospital
2023
Regenerative Medicine Institute
2022
EY Technologies (United States)
2022
Harbin Medical University
2014-2017
Improving the poor microenvironment in joint cavity has potential for treating cartilage injury, and mesenchymal stem cell (MSC)-derived exosomes (MSC-Exos), which can modulate cellular behavior, are becoming a new cell-free therapy repair. Here, we used acellular extracellular matrix (ACECM) to prepare 3D scaffolds 2D substrates by low-temperature deposition modeling (LDM) tape casting. We aimed investigate whether MSC-Exos cultured on of different dimensions could improve caused injury...
Abstract Despite numerous attempts to engineer cartilage tissue in recent years, significant challenges remain regarding hyaline regeneration. One main reason is that the overactivated inflammatory response after injury suppresses inherent regenerative capabilities. Since arthritic microenvironment constantly changing during posttraumatic stress, an diagnostic logic‐based hydrogel for regeneration developed first time through cross‐linking of 4‐arm poly(ethylene glycol)‐vinyl sulfone...
This study aimed to assess the prevalence of depressive symptoms and ADL/IADL disabilities explore their correlation associated factors for among community-dwelling older adults from low-income families in Dalian, Liaoning Province, China.This cross-sectional included 522 participants aged 60 years Dalian. The 30-Item Geriatric Depression Scale was employed measure symptoms. Katz ADL IADL were used evaluate performance activities necessary independent life. SPSS 22.0 analyze data. Logistic...
The harm of air pollution to public health has become a research hotspot, especially atmospheric fine-particulate matter (PM2.5). In recent years, epidemiological investigations have confirmed that PM2.5 is closely related chronic kidney disease and membranous nephropathy Basic demonstrated an impact on the normal function kidneys through accumulation in kidney, endothelial dysfunction, abnormal renin-angiotensin system, immune complex deposition. Moreover, mechanism damage involves...
Patulin (PAT) is a common mycotoxin, widely found in cereals, seafood, nuts, and especially fruits their products. Exposure to this mycotoxin has been reported induce kidney injury. However, the possible mechanism remains unclear. In our study, short-term high-dose intake of PAT caused acute injury (AKI) mice. We performed high-throughput transcriptional sequencing identify differentially expressed genes (DEGs) between treatment control groups. The ferroptosis signaling pathway had highest...
Reconstruction of the knee meniscus remains a significant clinical challenge owing to its complex anisotropic tissue organization, functions, and limited healing capacity in inner region. The development situ tissue-engineered meniscal scaffolds, which provide biochemical signaling direct endogenous stem/progenitor cell (ESPC) behavior, has potential revolutionize engineering. In this study, fiber-reinforced porous scaffold was developed based on aptamer Apt19S-mediated mesenchymal stem...
Existing evidence shows that there is an independent correlation between nephrolithiasis and gout, hyperuricemia the most important risk factor for gout. However, was often used as accompanying symptom of gout to explore its association with nephrolithiasis, were few studies whether itself or serum uric acid (SUA) related nephrolithiasis. Evidence on relationship still insufficient.A total 22,303 participants aged 30 79 years who participated in China Multi-Ethnic Cohort (CMEC) study Yunnan...
The utilization of decellularized extracellular matrix has gained considerable attention across numerous areas in regenerative research. Of particular interest is the human articular cartilage-derived (hACECM), which presents as a promising facilitator for cartilage regeneration. Concurrently, microfracture (MF) technique, well-established marrow stimulation method, proven efficacious repair defects. However, current literature review, no investigations have explored potential combined...
Background/Aims: Atherosclerosis is the primary cause of cardiovascular ischaemic events; arterial stiffness a characteristic atherosclerotic process. MicroRNAs (miRNAs) have been revealed as crucial modulators atherosclerosis. However, role stiffness-related miRNAs in process still unclear. Methods: Four hundred six participants from Northern China were enrolled this study. Circulating miR-1185 and adhesion molecule levels measured. Multiple linear regression models used to evaluate...
Exposure to air pollution has been closely associated with some cardiovascular disease. One of the mechanisms PM2.5 -mediated heart injury may be promote inflammation. We aim investigate whether main extract Houttuynia cordata, 2-undecanone, can prevent inflammation caused by , and reveal underlying mechanisms. The results showed that increased expression certain inflammatory cytokines, oxidative damage in BALB/c mice H9C2 cells. Supplementation 2-undecanone attenuated this -induced damage....
Purpose: Depression and anxiety are two highly prevalent mental disorders that commonly coexist. However, little is known about the association between sleep comorbid depressive symptoms (CDAS). Therefore, this study aims to explore relationship duration, insomnia CDAS. Methods: This a cross-sectional of 22,004 community adults who participated in China Multi-Ethnic Cohort (CMEC) study. Chinese version Patient Health Questionnaire-2 Generalized Anxiety Disorder-2 were used screen CDAS...