A5100414179- Acute Myeloid Leukemia Research
- Multiple Myeloma Research and Treatments
- Cervical Cancer and HPV Research
- Chronic Myeloid Leukemia Treatments
- Hippo pathway signaling and YAP/TAZ
- Autophagy in Disease and Therapy
- Protein Degradation and Inhibitors
- Acute Lymphoblastic Leukemia research
- Peptidase Inhibition and Analysis
- Erythropoietin and Anemia Treatment
- Endoplasmic Reticulum Stress and Disease
- Diabetes, Cardiovascular Risks, and Lipoproteins
- RNA Research and Splicing
- Histone Deacetylase Inhibitors Research
- Autoimmune and Inflammatory Disorders Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Hematological disorders and diagnostics
- Hematopoietic Stem Cell Transplantation
- Immune Cell Function and Interaction
- Iron Metabolism and Disorders
- Liver Disease Diagnosis and Treatment
- Zebrafish Biomedical Research Applications
- Mesenchymal stem cell research
- Hemoglobinopathies and Related Disorders
- Ubiquitin and proteasome pathways
Peking Union Medical College Hospital
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2009-2025
Shandong First Medical University
2022-2025
Children's Hospital of Capital Institute of Pediatrics
2025
National University of Singapore
2025
National University Cancer Institute, Singapore
2025
Shandong Tumor Hospital
2024-2025
Capital Medical University
2023-2025
Beijing Tongren Hospital
2023-2025
St. Jude Children's Research Hospital
2019-2024
How organ size is controlled in mammals not currently understood. In Drosophila the Hippo signaling pathway functions to suppress growth imaginal discs and has been suggested control size. To investigate role of hippo regulation mammalian we have generated conditional alleles Sav1 , mst1 mst2 orthologs Salvador respectively. Specific deletion both hepatocytes results significantly enlarged livers due excessive proliferation. By age 5–6 months, mst1/2 mutant multiple foci liver tumors,...
Stroke is much more prevalent than coronary heart disease in China; thus, any risk prediction model only for may not be appropriate application. Our objective to develop a cardiovascular the Chinese population.Cox proportional hazards regression was used sex-specific optimal 10-year models ischemic (ICVD; including stroke and events) from 17 years of follow-up data USA-PRC Collaborative Study Cardiovascular Epidemiology cohort, which 9903 participants were followed up every 2 until 2000, 371...
Restoration of local blood supply in the post-ischemic brain plays a critical role tissue repair and functional recovery. The present investigation explored beneficial effects recombinant human erythropoietin (rhEPO) on vascular endothelial cell survival, angiogenesis, restoration cerebral flow (LCBF) after permanent focal ischemia adult mice. Saline or rhEPO (5,000 U/kg, intraperitoneal) was administered 30 mins before once daily ischemic stroke. Immunohistochemistry showed an enhancing...
The risk of incident hypertension associated with long-term exposure to fine particulate matter (PM2.5) was still unclear by studies conducted in North America and Europe, this relationship has rarely been quantified at higher ambient concentrations typically found developing countries. We aimed investigate the association between PM2.5 using large-scale prospective cohorts China. included 59 456 participants without aged ≥18 years from China-PAR (Prediction for Atherosclerotic...
Abstract We used single cell RNA-Seq to examine molecular heterogeneity in multiple myeloma (MM) 597 CD138 positive cells from bone marrow aspirates of 15 patients at different stages disease progression. 790 genes were selected by coefficient variation (CV) method and organized into four groups (L1–L4) using unsupervised clustering. Plasma each patient clustered least two based on gene expression signature. The L1 group contained all MGUS having the lowest involved oxidative...
The neuropathological features of Alzheimer's disease include amyloid plaques. Rapidly emerging evidence suggests that Piezo1, a mechanosensitive cation channel, plays critical role in transforming ultrasound-related mechanical stimuli through its trimeric propeller-like structure, but the importance Piezo1-mediated mechanotransduction brain functions is less appreciated. However, apart from stimulation, Piezo1 channels are strongly modulated by voltage. We assume may play converting and...
In the last decade of 20th century, cardiovascular disease was leading cause death in China, accounting for one-third total deaths. comparison with western populations, mean body weight or mass index (BMI) Chinese population lower, but showed an increasing trend. Whether variation within lower levels BMI waist circumference associated other risk factors disease, and whether they contribute independently to population, investigated this study. keeping a uniform study design, each 14...
BackgroundPapanicolaou (Pap) triage, with high specificity, has been recommended for primary Human papillomavirus (HPV) testing but is flawed by poor sensitivity and cytologist dependence. We evaluated the potential role of microRNA (miRNA) detection in cervical exfoliated cells HPV-positive women from a clinic-based population.
Macrophage activation syndrome (MAS) is a life-threatening complication of systemic juvenile idiopathic arthritis (sJIA) characterised by vicious cycle immune amplification that can culminate in overwhelming inflammation and multiorgan failure. The clinical features MAS overlap with those active sJIA, complicating early diagnosis treatment. We evaluated adenosine deaminase 2 (ADA2), protein unknown function released principally monocytes macrophages, as novel biomarker MAS.We established...
Aims The role of tea consumption in the primary prevention atherosclerotic cardiovascular disease remains unclear cohort studies. This prospective study aimed to investigate associations with risk and all-cause mortality. Methods We included 100,902 general Chinese adults from project Prediction for ASCVD Risk China (China-PAR) 15 provinces across since 1998. Information on was collected through standardized questionnaires. Outcomes were identified by interviewing participants or their...
The specific breast milk-derived metabolites that mediate host-microbiota interactions and contribute to the onset of atopic dermatitis (AD) remain unknown require further investigation.
Abstract Background This study aimed to investigate the epidemiology of high-risk human papillomavirus (HPV) in female population Beijing, China, and identify relationship between HPV genotypes host factors. Methods testing was performed on women aged 15–89 (mean age 38.0 ± 10.9 years) from Beijing 2020. High-risk genotyping real-time polymerase chain reaction used determine genotypes. The overall prevalence, age-specific genotype distribution, correlation cervical cytology were analyzed....
The ability of 4-color flow cytometry (FC) to help identify myelodysplastic syndromes (MDSs) was evaluated in 124 bone marrow aspirates from unselected patients with unexplained cytopenias and/or monocytosis. morphologic features aspirate smears were correlated FC and cytogenetic findings blindly, patterns antigen expression compared seen nonneoplastic normal specimens. Of cases, 58 (46.7%) had definitive abnormalities ("flow-abnormal"), 19 cases (15.3%) mild indeterminate significance, 47...
Cell death induced by the combined insult of hypoxia-ischemia in neonatal rodents has been extensively investigated. Ischemia-only-induced cell death, however, much less characterized. Based on notion that 1) ischemic stroke is a relatively common disorder human neonates, and 2) developing cells are more susceptible to apoptosis, present study examined whether typical apoptosis was cerebral ischemia new rat model. Erythropoietin (EPO; Epoetin) tested for its protective effect against...
Multiple myeloma (MM) is still an incurable malignancy of plasma cells. Proteasome inhibitors (PIs) work as the backbone agent and have greatly improved outcome in majority newly diagnosed patients with myeloma. However, drug resistance remains major obstacle causing treatment failure clinical practice. Here, we investigated effects Indirubin-3'-monoxime (I3MO), one derivatives Indirubin, MM.MM patient primary samples human cell lines were examined. I3MO on underling molecular mechanisms via...
Objectives: To evaluate the impact of annual fluctuations in waist-to-height ratio (WHtR), an index central obesity, on cardiovascular disease (CVD) and all-cause mortality outcomes.
The polycomb protein EZH2 is up-regulated in Chronic Myeloid Leukaemia (CML) and associated with transcriptional reprogramming. Here we tested whether might also act as a modulator of the mRNA splicing landscape to elicit its oncogenic function CML. We treated CML cell lines inhibitors detected differential several hundreds events, potentially caused by regulation factors. Amongst those genes, CELF2 was identified candidate mediate part inhibitor induced phenotype. Upon over-expression,...
Neonatal sepsis (NS) is highly likely to cause death; however, early diagnosis of NS still a great challenge. This study aimed determine the diagnostic values IL-6, IL-8, and serum amyloid A (SAA) in patients. C-Reactive protein (CRP), procalcitonin (PCT), interleukin (IL)-6, SAA were detected 120 infants with (60 premature [NS-PIs] 60 term [NS-TIs]). Sixty noninfected composed control group. Receiver operating characteristic (ROC) curves used sensitivity specificity alone combination CRP...
Background: Neoadjuvant chemoradiotherapy (NCRT) combined with surgery is the standard treatment option for patients locally advanced esophageal squamous cell carcinoma (ESCC). However, whether adjuvant chemotherapy (AC) administered postoperatively has a survival benefit remains inconclusive. Objectives: To investigate AC necessary after NCRT and esophagectomy determine which might from it. Design: A retrospective study. Methods: This study examined ESCC treated followed by radical at three...
Globally, breast cancer is among the most frequent cancers, and tumor progression greatly impacted by immune system. Studies have revealed a correlation between phenotypes of cells incidence cancer; nevertheless, causal relationship has yet to be fully elucidated. Hence, we sought ascertain cell subtypes through implementation Mendelian randomization (MR). MR analysis utilized freely available genetic data explore causation link 731 susceptibility cancer, distinguishing estrogen...