A5057645984- Autoimmune and Inflammatory Disorders Research
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Inflammasome and immune disorders
- Adolescent and Pediatric Healthcare
- Pediatric Pain Management Techniques
- Tuberculosis Research and Epidemiology
- Cerebral Palsy and Movement Disorders
- Family and Disability Support Research
- Adenosine and Purinergic Signaling
- IL-33, ST2, and ILC Pathways
- Kawasaki Disease and Coronary Complications
- Long-Term Effects of COVID-19
- Systemic Lupus Erythematosus Research
- Amoebic Infections and Treatments
- COVID-19 Clinical Research Studies
- Immunodeficiency and Autoimmune Disorders
- Diagnosis and treatment of tuberculosis
- COVID-19 Impact on Reproduction
- Child Nutrition and Water Access
- Eosinophilic Disorders and Syndromes
- Acute Lymphoblastic Leukemia research
- Eosinophilic Esophagitis
- Global Health and Epidemiology
Boston Children's Hospital
2019-2023
Harvard University
2019-2023
Virginia–Maryland College of Veterinary Medicine
2023
Virginia Tech
2022-2023
Boston University
2019
Poor outcomes in COVID-19 correlate with clinical and laboratory features of cytokine storm syndrome. Broad screening for early, targeted antiinflammatory therapy may prevent immunopathology could help conserve limited health care resources. While studies are ongoing, extrapolating from experience syndromes benefit the multidisciplinary teams caring patients severe COVID-19.
BACKGROUND. Pediatric SARS–CoV-2 infection can be complicated by a dangerous hyperinflammatory condition termed multisystem inflammatory syndrome in children (MIS-C). The clinical and immunologic spectrum of MIS-C its relationship to other conditions childhood have not been studied detail.
Macrophage activation syndrome (MAS) is a life-threatening complication of systemic juvenile idiopathic arthritis (sJIA) characterised by vicious cycle immune amplification that can culminate in overwhelming inflammation and multiorgan failure. The clinical features MAS overlap with those active sJIA, complicating early diagnosis treatment. We evaluated adenosine deaminase 2 (ADA2), protein unknown function released principally monocytes macrophages, as novel biomarker MAS.We established...
Systemic juvenile idiopathic arthritis (sJIA) begins with fever, rash, and high-grade systemic inflammation but commonly progresses to a persistent afebrile arthritis. The basis for this transition is unknown. To evaluate role lymphocyte polarization, we characterized T cells from patients acute chronic sJIA using flow cytometry, mass RNA sequencing. Acute each featured an expanded population of activated Tregs uncommon in healthy controls or children nonsystemic JIA. In sJIA, expressed...
Background The relationship between malnutrition and tuberculosis (TB) severity is understudied. We investigated the effect of on radiographic findings mycobacterial burden. Methods Subjects included newly diagnosed, smear-positive, culture-confirmed, pulmonary TB cases enrolled in Regional Prospective Observational Research for (RePORT) cohort. Multivariate regression models were used to evaluate at start treatment body mass index (BMI) chest radiograph (CXR) cavitation percentage lung...
Oligoarticular juvenile idiopathic arthritis (oligo JIA) is the most common form of chronic inflammatory in children, yet cause this disease remains unknown. To understand immune responses oligo JIA, we immunophenotyped synovial fluid T cells with flow cytometry, bulk RNA-Seq, single-cell RNA-Seq (scRNA-Seq), DNA methylation studies, and Treg suppression assays. In fluid, CD4+, CD8+, γδ expressed Th1-related markers, whereas Th17 were not enriched. Th1 skewing was prominent CD4+ cells,...
T peripheral helper (Tph) cells, identified in the synovium of adults with seropositive rheumatoid arthritis, drive B cell maturation and antibody production non-lymphoid tissues. We sought to determine if similarly dysregulated cell-B interactions underlie another form inflammatory juvenile oligoarthritis (oligo JIA). Clonally expanded Tph cells able promote preferentially accumulated synovial fluid (SF) oligo JIA patients antinuclear antibodies (ANA) compared autoantibody-negative...
Introduction Eosinophilic Esophagitis (EoE) is a chronic allergic disease characterized by progressive inflammation of the esophageal mucosa. This inflammatory disorder affects up to 50 per 100,000 individuals in United States and Europe yet limited treatment options. While transcriptome EoE has been reported, few studies have examined genetics among cohort including both adult pediatric populations. To identify potentially overlooked biomarkers biopsies that may be promising targets for...
To compare clinical outcomes in children with hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS) who were managed before after implementation of an evidence-based guideline (EBG).A management algorithm for MAS-HLH was developed at our institution based on literature review, expert opinion, consensus building across multiple pediatric subspecialties. An electronic medical record search retrospectively identified hospitalized patients the pre-EBG (October 15,...
Juvenile idiopathic arthritis (JIA) is a cluster of autoimmune rheumatic diseases occurring in children 16 years age or less. While it well-known that pain may be experienced during inflammatory and non-inflammatory states, much remains ambiguous regarding the molecular mechanisms drive JIA pain. Thus, this pilot study, we explored variability serum proteomes relation to severity cohort patients. Serum samples from 15 patients (male female, 12.7 ± 2.8 age) were assessed using liquid...