A5101947070- Autoimmune and Inflammatory Disorders Research
- Inflammatory Myopathies and Dermatomyositis
- Vasculitis and related conditions
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Long-Term Effects of COVID-19
- Kawasaki Disease and Coronary Complications
- COVID-19 Clinical Research Studies
- Eosinophilic Disorders and Syndromes
- Renal Diseases and Glomerulopathies
- Neurogenetic and Muscular Disorders Research
- Coronary Artery Anomalies
- Adolescent and Pediatric Healthcare
- Child Abuse and Trauma
- Cardiac pacing and defibrillation studies
- Sarcoidosis and Beryllium Toxicity Research
- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Inflammasome and immune disorders
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Urticaria and Related Conditions
- Viral Infections and Immunology Research
- COVID-19 and Mental Health
- Musculoskeletal synovial abnormalities and treatments
- Cardiac Structural Anomalies and Repair
University of California, San Francisco
1998-2025
UCSF Benioff Children's Hospital
2017-2024
Massachusetts General Hospital
2020-2023
Northwestern University
2019-2023
University of California San Francisco Medical Center
2020-2022
Children's Hospital at Montefiore
2021-2022
Boston Children's Hospital
2005-2021
Icahn School of Medicine at Mount Sinai
2020-2021
Northwestern Medicine
2021
University of Southern California
2021
Vaccination reduces the risk of acute coronavirus disease 2019 (COVID-19) in children, but it is less clear whether protects against long COVID. We estimated vaccine effectiveness (VE) COVID children aged 5 to 17 years.
Objective To uniquely classify children with microscopic polyangiitis (MPA), to describe their demographic characteristics, presenting clinical features, and initial treatments in comparison patients granulomatosis (Wegener's) (GPA). Methods The European Medicines Agency (EMA) classification algorithm was applied by computation categorical data from recruited the ARChiVe (A Registry for Childhood Vasculitis: e‐entry) cohort, censored November 2015. EMA used distinguish MPA GPA, whose...
Abstract The relationship between amyloid-β (Aβ) species and tau pathology in Alzheimer’s disease (AD) is not fully understood. Here, we provide direct evidence that Aβ42/40 ratio, total Aβ level, plays a critical role inducing neurofibrillary tangles (NTFs) human neurons. Using 3D-differentiated clonal neural progenitor cells (hNPCs) expressing varying levels of amyloid β precursor protein (APP) presenilin 1 (PS1) with AD mutations, show pathogenic accumulation aggregation are tightly...
To use juvenile dermatomyositis (DM) survey data and expert opinion to develop a small number of consensus treatment protocols, which reflect current initial moderately severe DM.A meeting was held in Toronto, Ontario, Canada on December 1-2, 2007. Nominal group technique used achieve represented typical management DM. Consensus also reached as patients these protocols would be applicable (inclusion exclusion criteria), investigations should done prior initiating one collected evaluate the...
Abstract Kawasaki disease (KD) is a systemic vasculitis of unknown etiology. Absence definitive diagnostic markers limits the accuracy clinical evaluations suspected KD with significant increases in morbidity. In turn, incomplete understanding its molecular pathogenesis hinders identification rational targets needed to improve therapy. We used high‐accuracy mass spectrometry proteomics analyse over 2000 unique proteins urine specimens patients KD. discovered that proteomes KD, but not those...
Accurate risk prediction of coronary artery aneurysms (CAAs) in North American children with Kawasaki disease remains a clinical challenge. We sought to determine the predictive utility baseline dimensions adjusted for body surface area (z scores) future CAAs and explored extent which addition established Japanese scores z improved discrimination CAA development.We relationships scores; Kobayashi, Sano, Egami, Harada combination scores. defined as maximum score (zMax) ≥2.5 left anterior...
Juvenile dermatomyositis (JDM) is the most common form of idiopathic inflammatory myopathies in children. A subset children have rash JDM without significant weakness, and optimal treatments for these are unknown. The goal this study was to describe development consensus clinical treatment plans (CTPs) with who active skin rashes, muscle involvement, referred as predominant manuscript.The Children's Arthritis Rheumatology Research Alliance (CARRA) a North American consortium pediatric...
Systemic juvenile idiopathic arthritis (sJIA) begins with fever, rash, and high-grade systemic inflammation but commonly progresses to a persistent afebrile arthritis. The basis for this transition is unknown. To evaluate role lymphocyte polarization, we characterized T cells from patients acute chronic sJIA using flow cytometry, mass RNA sequencing. Acute each featured an expanded population of activated Tregs uncommon in healthy controls or children nonsystemic JIA. In sJIA, expressed...
Objective To provide evidence‐based recommendations and expert guidance for the management of Kawasaki disease (KD), focusing on clinical scenarios more commonly addressed by rheumatologists. Methods Sixteen questions regarding diagnostic testing, treatment, KD were developed in Patient/Population, Intervention, Comparison, Outcomes (PICO) question format. Systematic literature reviews conducted each PICO question. We used Grading Recommendations, Assessment, Development Evaluation method to...
Acute stroke attributable to internal carotid artery terminus occlusion carries a poor prognosis. Vessel recanalization is crucial improve clinical outcome. Historically, pharmacological thrombolysis alone has low rates. We sought determine whether adjunctive mechanical approaches achieve better vessel and functional outcome.We retrospectively reviewed 75 consecutive endovascular cases of acute occlusions treated at our center between 1998 2008. Mechanical (MERCI retrieval/angioplasty/stent)...
Objective. Juvenile dermatomyositis (JDM) is the most common form of idiopathic inflammatory myopathy in children. While outcomes are generally thought to be good, persistence skin rash a problem. The goal this study was describe development clinical treatment plans (CTP) for children with JDM characterized by persistent despite complete resolution muscle involvement. Methods. Childhood Arthritis and Rheumatology Research Alliance, North American consortium pediatric rheumatologists other...
Objective Treg cell–mediated suppression of Teff cells is impaired in juvenile idiopathic arthritis (JIA); however, the basis for this dysfunction incompletely understood. Animal models autoimmunity and immunodeficiency demonstrate that a diverse cell repertoire essential to maintain function. The present study was undertaken investigate repertoires JIA. Methods (CD4+CD25+CD127 low ) (CD4+CD25−) were isolated from peripheral blood synovial fluid obtained JIA patients, healthy controls,...
Objective To provide evidence‐based recommendations and expert guidance for the management of Kawasaki disease (KD), focusing on clinical scenarios more commonly addressed by rheumatologists. Methods Sixteen questions regarding diagnostic testing, treatment, KD were developed in Patient/Population, Intervention, Comparison, Outcomes (PICO) question format. Systematic literature reviews conducted each PICO question. We used Grading Recommendations, Assessment, Development Evaluation method to...
Methotrexate (MTX) is a readily accessible drug, first used in 1948 and employed for wide variety of indications since then. However, despite widespread off-label use, FDA labeling does not include approved the use MTX many inflammatory skin diseases pediatric patients, including morphea, psoriasis, atopic dermatitis, alopecia areata, among others. Without published treatment guidelines, some clinicians may be hesitant to off-label, or uncomfortable prescribing this population. To address...
The COVID-19 pandemic has been associated with increased neuropsychiatric conditions in children and youths, evidence suggesting that SARS-CoV-2 infection may contribute additional risks beyond stressors. This study aimed to assess the full spectrum of positive (ages 5-12) youths 12-20) compared a matched negative cohort, accounting for factors influencing risk. Using EHR data from 25 institutions RECOVER program, we conducted retrospective analysis 326,074 887,314 participants risk...
Importance The profile of gastrointestinal (GI) tract outcomes associated with the postacute and chronic phases COVID-19 in children adolescents remains unclear. Objective To investigate risks GI symptoms disorders during (28-179 days after documented SARS-CoV-2 infection) (180-729 pediatric population. Design, Setting, Participants This retrospective cohort study was performed from March 1, 2020, to September 2023, at 29 US health care institutions. included patients 18 years or younger...
Abstract IMPORTANCE Prior studies have demonstrated the effectiveness of COVID-19 vaccines in children and adolescents. However, benefits vaccination these age groups with prior infection remain underexplored. OBJECTIVE To evaluate preventing reinfection various Omicron subvariants (BA.1/2, BA.4/5, XBB, later) among 5- to 17-year-olds SARS-CoV-2 infection. DESIGN A target trial emulation through nested designs distinct study periods. SETTING The utilized data from Research COVID Enhance...