A5015035013- Vasculitis and related conditions
- Systemic Lupus Erythematosus Research
- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- T-cell and B-cell Immunology
- Sleep and Wakefulness Research
- Atherosclerosis and Cardiovascular Diseases
- Renal Diseases and Glomerulopathies
- Sleep and related disorders
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Urticaria and Related Conditions
- Sleep and Work-Related Fatigue
- Immune Cell Function and Interaction
- Cell Adhesion Molecules Research
- Diabetes and associated disorders
- Protein Tyrosine Phosphatases
- Otitis Media and Relapsing Polychondritis
- Gastrointestinal motility and disorders
- Kawasaki Disease and Coronary Complications
- Sarcoidosis and Beryllium Toxicity Research
- Genetic Associations and Epidemiology
- Cardiovascular Syncope and Autonomic Disorders
- Coronary Artery Anomalies
- Eosinophilic Disorders and Syndromes
- Cytokine Signaling Pathways and Interactions
University of California, San Francisco
2016-2025
Massachusetts General Hospital
2024
Harvard University
2024
Immune Tolerance Network
2021-2022
University of California San Francisco Medical Center
2021
American College of Rheumatology
2021
Toronto Western Hospital
1992-2017
University Health Network
2005-2017
University of Toronto
1995-2017
Rheumatology Research Center
2016
Obstructive sleep apnea (OSA) is a major risk factor for perioperative adverse events. However, no screening tool OSA has been validated in surgical patients. This study was conducted to develop and validate concise easy-to-use questionnaire patients.After hospital ethics approval, preoperative patients aged 18 yr or older without previously diagnosed were recruited. After analysis, reliability check, pilot study; four yes/no questions used this tool. The respectively related snoring,...
Systemic lupus erythematosus (SLE) is a clinically heterogeneous disease in which the risk of influenced by complex genetic and environmental contributions. Alleles HLA-DRB1, IRF5, STAT4 are established susceptibility genes; there strong evidence for existence additional loci.
Background Because of the high prevalence obstructive sleep apnea (OSA) and its adverse impact on perioperative outcome, a practical screening tool for surgical patients is required. This study was conducted to validate Berlin questionnaire American Society Anesthesiologists (ASA) checklist in compare them with STOP questionnaire. Methods After hospital ethics approval, preoperative aged 18 yr or older without previously diagnosed OSA were recruited. The scores from questionnaire, ASA...
Systemic lupus erythematosus (SLE) is a genetically complex disease with heterogeneous clinical manifestations. A polymorphism in the STAT4 gene has recently been established as risk factor for SLE, but relationship specific SLE subphenotypes not studied. We studied 137 SNPs region genotyped 4 independent case series (total n = 1398) and 2560 healthy controls, along data cases. Using conditional testing, we confirmed most significant haplotype risk. then SNP marking this association...
Systemic lupus erythematosus (SLE) is a clinically heterogeneous, systemic autoimmune disease characterized by autoantibody formation. Previously published genome-wide association studies (GWAS) have investigated SLE as single phenotype. Therefore, we conducted GWAS to identify genetic factors associated with anti-dsDNA production, SLE-related diagnostic and clinical importance. Using two independent datasets, over 400,000 nucleotide polymorphisms (SNPs) were studied in total of 1,717 cases...
Systemic lupus erythematosus (SLE) is a genetically complex disease with heterogeneous clinical manifestations. Recent studies have greatly expanded the number of established SLE risk alleles, but distribution multiple alleles in cases versus controls and their relationship to subphenotypes not been studied. We studied 22 susceptibility polymorphisms previous genome-wide evidence association (p < 5 x 10⁻¹²⁸) 1919 from 9 independent Caucasian case series 4813 controls. The mean was 15.1 (SD...
Objective To identify risk alleles relevant to the causal and biologic mechanisms of antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV). Methods A genome‐wide association study subsequent replication were conducted in a total cohort 1,986 cases AAV (patients with granulomatosis polyangiitis [Wegener's] [GPA] or microscopic [MPA]) 4,723 healthy controls. Meta‐analysis these data sets functional annotation identified loci performed, candidate disease variants unknown...
Lupus nephritis is a manifestation of SLE resulting from glomerular immune complex deposition and inflammation. demonstrates familial aggregation accounts for significant morbidity mortality. We completed meta-analysis three genome-wide association studies to identify lupus nephritis-predisposing loci. Through genotyping imputation, >1.6 million markers were assessed in 2000 unrelated women European descent with (588 patients 1412 without nephritis). Tests computed using logistic regression...
The COPA syndrome is a monogenic, autoimmune lung and joint disorder first identified in 2015. This study sought to define the main pulmonary features of an international cohort patients, analyse patient responses treatment highlight when genetic testing should be considered. We established subjects (N=14) with seen at multiple centres including University California, San Francisco, CA, USA. All had one previously mutations gene, clinically apparent disease arthritis. analysed...
Decreases in melatonin production human and animals are known to be caused by environmental lighting, especially short-wavelength lighting (between 470 525 nm). We investigated the novel hypothesis that use of goggles with selective exclusion all wavelengths less than 530 nm could prevent suppression bright-light conditions during a simulated shift-work experiment. Salivary levels were measured under dim (<5 lux), bright (800 filtered lux) light at hourly intervals between 2000 0800 h 11...
Shift work is a ubiquitous phenomenon and its adverse effects on workers' physical mental health have been documented. In the sleep literature, differentiating between symptoms of fatigue sleepiness, developing appropriate objective subjective measures, become very important endeavors. From such research, sleepiness shown to be distinct independent phenomena. However, it not known whether shift differentially affects sleepiness. an attempt answer this question, 489 workers from major Ontario...
A substantial genetic contribution to systemic lupus erythematosus (SLE) risk is conferred by major histocompatibility complex (MHC) gene(s) on chromosome 6p21. Previous studies in SLE have lacked statistical power and resolution fully define MHC influences. We characterized 1,610 Caucasian cases 1,470 parents for 1,974 SNPs, the highly polymorphic HLA-DRB1 locus, a panel of ancestry informative markers. Single-marker analyses revealed strong signals SNPs within several regions, as well with...
Immune-mediated nephritis contributes to disease in systemic lupus erythematosus, Goodpasture syndrome (caused by antibodies specific for glomerular basement membrane [anti-GBM antibodies]), and spontaneous nephritis. Inbred mouse strains differ susceptibility anti-GBM antibody-induced This study sought clarify the genetic molecular factors that maybe responsible enhanced immune-mediated renal these models. When kidneys of 3 sensitive were compared with those 2 control using microarray...