A5046837311- Dermatology and Skin Diseases
- Allergic Rhinitis and Sensitization
- Urticaria and Related Conditions
- Asthma and respiratory diseases
- Food Allergy and Anaphylaxis Research
- Psoriasis: Treatment and Pathogenesis
- Autoimmune and Inflammatory Disorders Research
- Parvovirus B19 Infection Studies
- Neonatal skin health care
- Autoimmune Bullous Skin Diseases
- Pharmacological Effects of Natural Compounds
- Eosinophilic Disorders and Syndromes
- Vascular Malformations and Hemangiomas
- Dermatological and COVID-19 studies
- Kawasaki Disease and Coronary Complications
- Soft tissue tumor case studies
- Acne and Rosacea Treatments and Effects
- Systemic Sclerosis and Related Diseases
- Genetic and rare skin diseases.
- Cancer and Skin Lesions
- Cutaneous lymphoproliferative disorders research
- Hormonal and reproductive studies
- Herpesvirus Infections and Treatments
- Herbal Medicine Research Studies
- Pharmaceutical studies and practices
Rady Children's Hospital-San Diego
2016-2025
University of California, San Diego
2016-2025
College of Podiatry
2024
Nationwide Children's Hospital
2023
University of California System
2019
University of San Diego
2014
Boston Children's Hospital
2013
Saint Louis University
2006
Foundation for Anesthesia Education and Research
2000
San Francisco VA Medical Center
2000
Additional topical treatments for atopic dermatitis (AD) are needed that provide relief while minimizing risks.We sought to assess the efficacy and safety of crisaborole ointment, a phosphodiesterase 4 inhibitor, in two phase III AD studies (AD-301: NCT02118766; AD-302: NCT02118792).Two identically designed, vehicle-controlled, double-blind enrolled randomly assigned (2:1, crisaborole:vehicle) patients aged 2 years or older with an Investigator's Static Global Assessment (ISGA) score mild...
The aetiology and exact incidence of infantile haemangiomas (IHs) are unknown. Prior studies have noted immunohistochemical biological characteristics shared by IHs placental tissue.We investigated the possible association between anomalies development IHs, as well demographic other risk factors for IHs.Pregnant women (n = 578) were prospectively enrolled their offspring followed 9 months. Placental evaluations performed data collected on all mother-infant pairs.We evaluated 594 infants: 34...
To investigate the relationship of excess and central adiposity with pediatric psoriasis severity.Multicenter, cross-sectional study 409 psoriatic children. Psoriasis was classified as mild (worst Physician's Global Assessment score ≤3 body surface area ≤10%) or severe ≥3 >10%). Children were enrolled from 9 countries between June 19, 2009, December 2, 2011.Excess (body mass index percentile) (waist circumference percentile waist to height ratio).Excess ≥85th occurred in 37.9% children...
Abstract Propranolol is a non‐selective beta‐adrenergic antagonist successfully used in case of kaposiform hemangioendothelioma (KHE) associated with Kasabach–Merritt phenomenon (KMP). We report 11 patients treated propranolol for KHE and the related variant tufted angioma (TA), six whom also had KMP. The varied responses to treatment, only 36% responding our series, demonstrate need further study this medication before routine use these indications. Pediatr Blood Cancer 2012; 59: 934–938. ©...
Abstract The clinical features of pediatric psoriasis warrant further attention. A national study was conducted to determine the prevalence scalp and nail involvement a history guttate at onset according age, sex, disease severity. One hundred eighty‐one children ages 5 17 years with plaque were enrolled in multicenter, cross‐sectional study. Subjects guardians asked about whether initial presentation guttate. Peak severity assessed defined historically as mild ( MP ) or severe SP P...
<h3>Importance</h3> Psoriasis is a complex inflammatory skin condition associated with serious medical comorbidities in adults, including obesity, hypertension, dyslipidemia, type 2 diabetes mellitus, psoriatic arthritis, nonalcoholic fatty liver disease, depression, anxiety, and decreased quality of life. Because psoriasis begins childhood almost one-third patients, early identification risk may be critical to minimizing effects on future health. <h3>Objective</h3> To develop the first set...
Chronic skin disorders in children frequently are visible and can cause stigmatization. However, the extent of stigmatization from chronic disease association with mental health needs further study.
Use of systemic therapies for moderate to severe psoriasis in children is increasing, but comparative data on their use and toxicities are limited.To assess patterns relative risks agents children.A retrospective review was conducted at 20 centers North America Europe, included all consecutive with who used medications or phototherapy least 3 months from December 1, 1990, September 16, 2014.The minimal core set age, sex, severity psoriasis, interventions, monitoring, adverse events (AEs),...
Phosphodiesterase-4 (PDE4) is an emerging target in treating inflammatory skin diseases. Crisaborole topical ointment, 2% a novel, boron-based, PDE4 inhibitor under investigation for treatment of mild to moderate atopic dermatitis (AD).Adolescent patients aged 12 17 years with treatable AD lesions involving ≥ 10% ≤ 35% body surface area (BSA) were enrolled into phase 2a, open-label study comprising pharmacokinetic (PK), safety, tolerability, and efficacy assessments. was applied twice daily...
As for adult psoriasis, pediatric psoriasis has recently been associated with obesity, increased waist circumference percentiles and waist-to-height ratios, metabolic laboratory abnormalities1-3 (Supplemental Table 1). Although obesity could theoretically result from the functional limitations psychosocial impact of females self-reported that developed before psoriasis4 high BMI in adolescent girls preceded hospitalization adults5. Whether precedes or leads to childhood not addressed. In a...
Methotrexate (MTX) is a readily accessible drug, first used in 1948 and employed for wide variety of indications since then. However, despite widespread off-label use, FDA labeling does not include approved the use MTX many inflammatory skin diseases pediatric patients, including morphea, psoriasis, atopic dermatitis, alopecia areata, among others. Without published treatment guidelines, some clinicians may be hesitant to off-label, or uncomfortable prescribing this population. To address...
Crisaborole ointment, 2%, is a nonsteroidal phosphodiesterase 4 inhibitor for the treatment of patients with mild-to-moderate atopic dermatitis (AD).
<h3>Importance</h3> Few studies have compared the use of methotrexate and biologics, most commonly used systemic medications for treatment moderate to severe psoriasis in children. <h3>Objective</h3> To assess real-world, 6-month reduction severity long-term drug survival (rate duration adherence a specific drug) vs biologics plaque <h3>Design, Setting, Participants</h3> A retrospective medical records review was conducted at 20 European North American centers. Treatment response based on...