A5083625621- Dermatology and Skin Diseases
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Skin and Cellular Biology Research
- melanin and skin pigmentation
- Psoriasis: Treatment and Pathogenesis
- Food Allergy and Anaphylaxis Research
- Antibiotic Resistance in Bacteria
- Autoimmune Bullous Skin Diseases
- Contact Dermatitis and Allergies
- Cutaneous Melanoma Detection and Management
- Drug-Induced Adverse Reactions
- Nail Diseases and Treatments
- Bacterial biofilms and quorum sensing
- Acne and Rosacea Treatments and Effects
- Skin Protection and Aging
- Cancer Immunotherapy and Biomarkers
- Vitamin C and Antioxidants Research
- Obstructive Sleep Apnea Research
- Child Nutrition and Feeding Issues
- Inflammatory mediators and NSAID effects
- Syphilis Diagnosis and Treatment
- Neuroscience of respiration and sleep
- Potassium and Related Disorders
- IL-33, ST2, and ILC Pathways
Northwestern University
2016-2025
George Washington University
2022
Ponce Health Sciences University
2020
Molecular profiling of skin biopsies is the criterion standard for evaluating cutaneous atopic dermatitis (AD) phenotype. However, are not always feasible in children. A reproducible minimally invasive approach that can track disease pediatric longitudinal studies or clinical trials lacking.To assess a using tape strips to identify biomarkers may serve as surrogate identified whole-tissue biopsies.This cross-sectional study 51 children younger than 5 years recruited with moderate severe AD...
Skin biopsies promote our understanding of atopic dermatitis/AD pathomechanisms in infants/toddlers with early-onset AD, but are not feasible pediatric populations. Tape strips an emerging, minimally invasive alternative, global transcriptomic profiling early AD is lacking. We aimed to provide lesional and nonlesional skin profiles recent-onset, moderate-to-severe using tape strips.Sixteen were collected for RNA-seq from 19 (<5 years old; nonlesional) (≤6 months) 17 healthy controls.We...
Chronic skin disorders in children frequently are visible and can cause stigmatization. However, the extent of stigmatization from chronic disease association with mental health needs further study.
Hospital-acquired pneumonia is associated with high rates of morbidity and mortality, dissemination to the bloodstream a recognized risk factor for particularly poor outcomes. Yet mechanism by which bacteria in lungs gain access remains poorly understood. In this study, we used mouse model Pseudomonas aeruginosa examine mechanism. P. uses type III secretion system deliver effector proteins such as ExoS directly into cytosol eukaryotic cells. ExoS, bi-functional GTPase activating protein...
Many Gram-negative bacteria produce outer membrane vesicles (OMVs) during cell growth and division, some bacterial pathogens deliver virulence factors to the host via release of OMVs infection. Here we show that Yersinia pestis, causative agent disease plague, produces releases native under physiological conditions. These OMVs, approximately 100 nm in diameter, contain multiple virulence-associated proteins including adhesin Ail, F1 fimbrial antigen, protease Pla. We found released by Y....
ABSTRACT Background/Objectives Bullying of children with chronic disorders is associated an increased risk depression, anxiety, poor self‐esteem, and suicidal ideation. Congenital ichthyoses are genodermatoses extensive visible scaling inflammation. a frequent concern families ichthyosis but rarely discussed or investigated. Methods experience the impact on their caregivers were investigated utilizing survey methodology validated questionnaires. Correlations explored between demographic...
Clinical infections by Pseudomonas aeruginosa, a deadly Gram-negative, opportunistic pathogen of immunocompromised hosts, often involve the formation antibiotic-resistant biofilms. Although biofilm has been extensively studied in vitro on glass or plastic surfaces, much less is known about at epithelial barrier. We have previously shown that when added to apical surface polarized cells, P. aeruginosa rapidly forms cell-associated aggregates within 60 minutes infection. By confocal microscopy...
The necessity of serum potassium monitoring for healthy women who are prescribed spironolactone acne has been debated. aim this study was to compare the incidence hyperkalemia in 18 45 years age that 46 65 age, when treated with oral acne. Data all were by a dermatologist between January 2006 and October 2016 extracted analysis. Retrospective data included exhibited baseline within normal limits had repeat 12 months after initiation spironolactone. rate incident determined. Of 618 received...
Abstract There have been over 769 million cases of COVID-19, and up to 50% infected individuals are asymptomatic. The purpose this study aimed assess the use a clinical-grade physiological wearable monitoring system, ANNE One, develop an artificial intelligence algorithm for (1) cough detection (2) early through retrospective analysis prospectively collected data from longitudinal wear sensors in multicenter single arm subjects at high risk COVID-19 due occupational or home exposures....
Pseudomonas aeruginosa is a Gram-negative pathogen commonly associated with nosocomial infections such as hospital-acquired pneumonia. It uses type III secretion system to deliver effector proteins directly into the cytosol of host cells. Type in P. has been linked severe disease and worse clinical outcomes animal human studies. The majority strains secrete ExoS, bifunctional toxin GTPase-activating protein ADP-ribosyltransferase activities. Numerous vitro studies have investigated targets...