A5046152936- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Neonatal Health and Biochemistry
- Hepatitis C virus research
- Dermatology and Skin Diseases
- Hepatitis B Virus Studies
- Urticaria and Related Conditions
- Liver Disease Diagnosis and Treatment
- Cytomegalovirus and herpesvirus research
- Long-Term Effects of COVID-19
- Asthma and respiratory diseases
- COVID-19 epidemiological studies
- Allergic Rhinitis and Sensitization
- Atrial Fibrillation Management and Outcomes
- Chronic Disease Management Strategies
- Cardiac Health and Mental Health
- Rheumatoid Arthritis Research and Therapies
- Vitamin C and Antioxidants Research
- Primary Care and Health Outcomes
- Musculoskeletal synovial abnormalities and treatments
- Effects and risks of endocrine disrupting chemicals
- Microscopic Colitis
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Inflammasome and immune disorders
- Autoimmune and Inflammatory Disorders Research
Clalit Health Services
2016-2025
Tel Aviv University
2016-2025
Ariel University
2025
Gilead Sciences (United States)
2022
Sheba Medical Center
2016-2020
Israeli Association for Cardiovascular Trials
2016
Israel Ministry of Health
2016
University of Rochester Medical Center
2016
Old Dominion University
2012
Hadassah Medical Center
2009-2010
Immune protection following either vaccination or infection with SARS-CoV-2 is thought to decrease over time. We designed a retrospective study, conducted at Leumit Health Services in Israel, determine the kinetics of IgG antibodies administration two doses BNT162b2 vaccine, unvaccinated individuals. Antibody titers were measured between 31 January 2021, and July 2021 mutually exclusive groups: (i) vaccinated individuals who received vaccine had no history previous COVID-19 (ii)...
To determine whether time elapsed since the second injection of Pfizer-BioNTech BNT162b2 mRNA vaccine was significantly associated with risk covid-19 infection after vaccination in people who received two injections.Test negative design study.Electronic health records a large state mandated healthcare organisation, Israel.Adults aged ≥18 years had reverse transcription polymerase chain reaction (RT-PCR) test between 15 May 2021 and 17 September 2021, at least three weeks their injection, not...
The independent association between elevated triglycerides and all-cause mortality among patients with established coronary heart disease is controversial. aim of this study was to investigate in a large cohort proven disease.The comprised 15 355 who were screened for the Bezafibrate Infarction Prevention (BIP) trial. Twenty-two-year data obtained from national registry. Patients divided into 5 groups according strata fasting serum triglycerides: (1) low-normal (<100 mg/dL); (2) high-normal...
Immune protection following either vaccination or infection with SARS-CoV-2 decreases over time. To determine the kinetics of IgG antibodies administration two doses BNT162b2 vaccine, in unvaccinated individuals. Antibody titers were measured between January 31, 2021, and July 2021 mutually exclusive groups: i) vaccinated individuals who received vaccine had no history previous COVID-19 ii) convalescents not vaccine. A total 2,653 fully by during study period 4,361 convalescent patients...
Abstract Importance Israel was among the first countries to launch a large-scale COVID-19 vaccination campaign, and quickly vaccinated its population, achieving early control over spread of virus. However, number cases is now rapidly increasing, which may indicate that vaccine protection decreases time. Objective To determine whether time elapsed since second BNT162b2 messenger RNA (mRNA) (Pfizer-BioNTech) injection significantly associated with risk post-vaccination infection. Design This...
Background: The factors that trigger and exacerbate chronic spontaneous urticaria (CSU) are well known, but it is not unclear whether messenger RNA (mRNA) vaccination against severe acute respiratory syndrome coronavirus 2 can new cases of CSU or a relapse after long-term remission. Objective: To study the clinical patients with new-onset in remission who relapsed within 3 months BNT162b2 mRNA vaccination. Methods: All diagnosis 12 weeks were retrospectively identified included groups. first...
Background: The relationship between fibromyalgia (FM) and allergic diseases remains poorly understood, despite emerging evidence that suggests a possible association. Objective: This study aimed to evaluate the prevalence of comorbidities in patients with FM compared matched control group. Methods: We conducted retrospective, population-based case-control within Leumit Health Services, which caters ∼750,000 members. Patients meeting evolving criteria American College Rheumatology from...
microRNAs (miRNAs) are small noncoding RNAs that regulate cognate mRNAs post-transcriptionally. miRNAs have been implicated in regulating gene expression embryonic developmental processes, including proliferation and differentiation. The liver is a multifunctional organ, which undergoes rapid changes during the period relies on tightly-regulated expression. Little known regarding complex patterns of both early stages human development, role regulation this process has not studied. aim work...
Hepatocellular carcinoma (HCC) is the third leading cause of cancer mortality worldwide and considered to be outcome chronic liver inflammation. Currently, main treatment for HCC surgical resection. However, survival rates are suboptimal partially because tumor recurrence in remaining liver. Our aim was understand molecular mechanisms linking regeneration under inflammation hepatic tumorigenesis. Mdr2-KO mice, a model inflammation-associated cancer, underwent partial hepatectomy (PHx), which...
Abstract BACKGROUND Smokers are generally more susceptible to infectious respiratory diseases and at higher risk of developing severe complications from these infections. Conflicting reports exist regarding the impact smoking on Coronavirus disease 2019 (COVID-19). METHODS We carried out a population-based study among over 3,000,000 adult members Clalit Health Services, largest health provider in Israel. Since beginning outbreak, until May 16, 2020, 145,000 adults underwent RT-PCR testing...
Until coronavirus disease 2019 (COVID-19) drugs specifically developed to treat COVID-19 become more widely accessible, it is crucial identify whether existing medications have a protective effect against severe disease. Toward this objective, we conducted large population study in Clalit Health Services (CHS), the largest healthcare provider Israel, insuring over 4.7 million members.
This study examines the demographic, clinical and socioeconomic factors associated with diagnosis of long COVID syndrome (LCS). Data 20,601 COVID-19-positive children aged 5 to 18 years were collected between 2020 2021 in an Israeli database. Logistic regression analysis was used evaluate adjusted odds ratio for characteristics COVID-19 infection pre-COVID-19 morbidities. Children LCS significantly more likely have been severely symptomatic, required hospitalization, experienced recurrent...
Invasive Candida infections pose a major public health problem worldwide and is cause of nosocomial bloodstream infection. Our aim was to assess dynamics in incidence, species distribution antifungal susceptibility candidemia episodes Jerusalem, better understand the epidemiology invasive isolates direct therapy. Methods We analyzed incidence dynamics, pattern 899 during 2005-2016 Jerusalem. Results The overall relatively low 0.62 per 1000 admissions. albicans leading pathogen (39.4%);...
Abstract BACKGROUND Recent studies suggest a link between vitamin D deficiency and Covid-19 infection. In our population we observe major differences in incidence ethnic groups genders each group. METHODS We carried out population-based study among 4.6 million members of Clalit Health Services (CHS). collected results from tests performed 2010 2019 used weighted linear regression to assess the relationship prevalence 200 localities. Additionally, matched 52,405 infected patients with 524,050...
Background: Studies have demonstrated that 50% to 80% of patients do not receive an International Classification Diseases (ICD) code assigned their medical encounter or condition. For these patients, clinical information is mostly recorded as unstructured free-text narrative data in the record without standardized coding extraction structured elements. Leumit Health Services (LHS) collaboration with Israeli Ministry (MoH) conducted this study using electronic records (EMRs) systematically...
<ns4:p><ns4:bold>Background</ns4:bold>: Atopic dermatitis (AD), the most common chronic inflammatory skin disease, is evolving as a systemic and associated inflammation possibly linked to increases in cardiovascular disease.</ns4:p><ns4:p> <ns4:bold>Methods</ns4:bold>: We assessed levels of marker CRP 59 patients with moderate-to-severe AD compared matched healthy controls, determine correlation disease severity. Clinical severity was measured using SCORing Dermatitis (SCORAD) body surface...
Introduction There are limited contemporary data regarding the association between improvement in cardiovascular fitness heart failure patients who participate a cardiac rehabilitation programme and risk of subsequent hospitalisations. Methods The study population comprised 421 with participated our years 2009 2016. All were evaluated by standard exercise stress test before initiation, underwent second on completion 3 ± 1 months training. Participants dichotomised level at baseline,...
Abstract Background Our study aimed to compare disease characteristics, medication utilization, procedures performed, and hospitalizations between IBD patients treated in hospital community settings using the Leumit Health Service database. Methods A retrospective cohort was conducted data from Service, comprising 3020 diagnosed with fBetween 2010 -2019. Patients were divided based on primary care setting: hospital-based or community-based. Data included demographic type, usage, procedures,...