A5100610764- Cancer Genomics and Diagnostics
- Liquid Crystal Research Advancements
- Pluripotent Stem Cells Research
- Electrochemical sensors and biosensors
- Organometallic Complex Synthesis and Catalysis
- Genomic variations and chromosomal abnormalities
- Pituitary Gland Disorders and Treatments
- Cardiac Ischemia and Reperfusion
- Educational Systems and Policies
- DNA and Nucleic Acid Chemistry
- Edible Oils Quality and Analysis
- RNA Interference and Gene Delivery
- Education and Learning Interventions
- Semiconductor materials and devices
- Technology and Data Analysis
- RNA and protein synthesis mechanisms
- Neuroscience and Neuropharmacology Research
- Renal and related cancers
- Chronic Myeloid Leukemia Treatments
- Consumer Perception and Purchasing Behavior
- Ubiquitin and proteasome pathways
- Autism Spectrum Disorder Research
- Metal complexes synthesis and properties
- RNA Research and Splicing
- Tissue Engineering and Regenerative Medicine
Korea Institute of Science & Technology Information
2018-2025
Catholic University of Korea
2016-2024
Uijeongbu St. Mary's Hospital
2024
Hokkaido University
2024
Donald & Barbara Zucker School of Medicine at Hofstra/Northwell
2023
Northwell Health
2022-2023
Pusan National University
2022-2023
Yonsei University
2002-2023
Korea Institute of Science and Technology
2002-2023
Hansol Chemical (South Korea)
2020-2023
Directed differentiation of human induced pluripotent stem cells (hiPSC) into functional, region-specific neural is a key step to realizing their therapeutic promise treat various disorders, which awaits detailed elucidation.We analyzed from hiPSC lines generated by others and ourselves. Although heterogeneity in efficiency neuroepithelial (NE) cell was observed among different lines, the NE process resembles that embryonic (hESC) morphology, timing, transcriptional profile, requirement for...
We studied various tests of thyroid function in sick patients with nonthyroidal illness (NTI) order to determine the utility each test for differentiating these from a group hypothyroidism. evaluated 22 healthy volunteers who served as controls, 20 hypothyroidism, 14 admitted medical intensive care unit whose serum T4 was less than 5 μg/dl, 13 chronic liver disease, 32 on hemodialysis renal failure, ambulatory oncology receiving chemotherapy, 16 pregnant women, 7 women estrogens, and...
Throughout an individual's lifetime, genomic alterations accumulate in somatic cells
Brain somatic mutations in mTOR pathway genes are a major genetic etiology of focal cortical dysplasia type II (FCDII). Despite greater ability to detect low-level the brain by deep sequencing and analytics, about 40% cases remain genetically unexplained.We included 2 independent cohorts consisting 21 patients with mutation-negative FCDII without apparent on conventional bulk brain. To find ultra-low level variants or structural variants, we isolated cells exhibiting phosphorylation S6...
Curcumin has been used in traditional Indian medicine for many centuries its anti-inflammatory and anti-carcinogenic properties. There some promising research concerning curcumin as a safe therapeutic agent cancers, colorectal cancer being among them. This shown through cell cultures, animal models, humans. At this time, it appears that curcumin's properties are most likely due to effects on multiple molecular targets, such nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB)...
<b>Background and study aims:</b> Cold biopsy forceps polypectomy (CBP) is commonly used for the removal of diminutive polyps; however, evidence efficacy CBP lacking. The aim this was to evaluate adequacy resection polyps identify predictors complete using CBP. <b>Patients methods:</b> This a prospective from tertiary referral hospital in Korea. A total 196 patients were screened, 65 with enrolled. resect until no polyp visible by chromoendoscopy indigo carmine spray. Each base then resected...
This study investigates the thermodynamic parameters of 1300 RNA/DNA hybrid duplexes, including both natural and chemically modified forms, using molecular dynamics (MD) simulations. Modified duplexes consist phosphorothioate (PS) backbones 2'-O-methoxyethyl (MOE) modifications, commonly used in therapeutic oligonucleotides. Hybridization enthalpy entropy were calculated from MD trajectories mechanics Poisson-Boltzmann surface area (MMPBSA) generalized Born (MMGBSA) approaches. To address...
Faradaic electrochemical impedance spectroscopy (f-EIS) in the presence of redox reagent, e.g., [Fe(CN)6]3−/4−, is widely used biosensors owing to its high sensitivity. However, sensors detecting amyloid beta (Aβ), reagent can cause aggregation Aβ, which a disturbance factor accurate detection. Here, we propose an interdigitated microelectrode (IME) based f-EIS technique that alleviate Aβ and achieve sensitivity by buffer control. The proposed method was verified analyzing three different...
Abstract The multidrug transporter ABCG2 in cell membranes enables various stem cells and cancer to efflux chemicals, including the fluorescent dye Hoechst 33342. Hoechst− can be sorted out as a side population with properties. Abcg2 expression mouse embryonic (ESCs) reduces accumulation of DNA-damaging metabolites cells, which helps prevent differentiation. Surprisingly, we found that human ESCs do not express cannot Hoechst. In contrast, trophoblasts neural epithelial derived from are...
Abstract The role of oxygen‐limitation on lipid oxidation and moisture content were tested in corn oil heated to 60, 100, 140 °C. degree was determined by analyzing headspace oxygen content, conjugated dienoic acids (CDA), p ‐anisidine value ( ‐AV). bulk analyzed the Karl Fischer method. Oxygen‐limited samples 100 °C had significantly more than oxygen‐unlimited at early timepoints < 0.05). After this period, based CDA ‐AV assays. During those initial periods, oxygen‐limited higher 0.05),...
Background 5-hydroxytryptamine type 3 (5-HT3) receptor antagonists are effective and safe on postoperative nausea vomiting (PONV). Palonosetron, the newest 5-HT3 antagonist, has potent antiemetic property. We hypothesized that a combination of palonosetron dexamethasone could more decrease PONV than alone. Methods Among patients scheduled to undergo laparoscopic gynecologic surgery, mastoidectomy with tympanoplasty or thyroidectomy under general anesthesia, eighty four female at least two...
Objectives: This study was conducted to determine the number of hours worked per week by full-time wage workers using data Korean Labor and Income Panel Study (KLIPS), which represents domestic urban area household, association between weekly working level self-rated health. Methods:We used from 11th KLIPS in 2008.The subjects this were 3,699 ages 25 64 years.The health analyzed considering socio-demographic characteristics, work environment, health-related behaviors.Results: Among workers,...
Human embryonic stem cell (hESC) derived mesenchymal cells (EMSC) are efficacious in treating a series of autoimmune, inflammatory, and degenerative diseases animal models.However, all the EMSC derivation methods reported so far rely on two-dimensional (2D) culture systems, which inefficient, costive difficult for large-scale production.HESC, as an unlimited source, can be successively propagated spheroids.Here, we demonstrate that hESC spheroids directly differentiate into MSC (EMSCSp)...
Short tandem repeats (STRs) are repetitive DNA sequences and highly mutable in various human disorders. While the involvement of STRs genetic disorders has been extensively studied, their role autism spectrum disorder (ASD) remains largely unexplored. In this study, we aimed to investigate association STR expansions with ASD using whole genome sequencing (WGS) identify risk loci associated phenotypes.
Mesenchymal stem cells (MSC) have been derived from a variety of tissues, and cultured either in animal serum-containing (SC) or serum-free (SF) media. We previously MSC human embryonic via an intermediate trophoblast step (named EMSC), which also immunosuppressive therapeutic effects on models autoimmune disease. To promote the clinical application this new source MSC, we report here EMSC SF medium MesenCult (SF-EMSC) comparison with SC (SC-EMSC). SF-EMSC expressed typical markers CD73,...
Silibinin, the flavonoid found in milk thistle, has been shown to suppress cell growth and exhibit anti-cancer effects. Some flavonoids were reported inhibit angiogenesis which is essential for tumor metastasis. In this study, clarify underlying mechanisms effect of silibinin, we examined effects silibinin on human endothelial ECV304 cells. Silibinin was induce apoptosis The induction by confirmed ladder-patterned DNA fragmentation, cleaved condensed nuclear chromatin hypoploidy. could...