A5077802602- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Cervical and Thoracic Myelopathy
- Scoliosis diagnosis and treatment
- Musculoskeletal pain and rehabilitation
- Streptococcal Infections and Treatments
- Orthopaedic implants and arthroplasty
- Spinal Dysraphism and Malformations
- Infectious Diseases and Tuberculosis
- Mesenchymal stem cell research
- Pluripotent Stem Cells Research
- Medical Imaging and Analysis
- Bone Tissue Engineering Materials
- Tissue Engineering and Regenerative Medicine
First Affiliated Hospital of Guangzhou Medical University
2017-2023
Guangzhou Medical University
2017-2023
Southern Medical University
2017-2019
Guangzhou Institute of Dermatology
2017
Human embryonic stem cell (hESC) derived mesenchymal cells (EMSC) are efficacious in treating a series of autoimmune, inflammatory, and degenerative diseases animal models.However, all the EMSC derivation methods reported so far rely on two-dimensional (2D) culture systems, which inefficient, costive difficult for large-scale production.HESC, as an unlimited source, can be successively propagated spheroids.Here, we demonstrate that hESC spheroids directly differentiate into MSC (EMSCSp)...
Lumbar fusion is a popular surgical procedure for the treatment of degenerative lumbar disc disease; however, it may be accompanied by complications, such as cage loosening, subsidence, and non-union. This study engineered fabricated three-dimensional (3D)-printed anisotropic biomimetic trabecular porous Ti-6Al-4V interbody fusion. The evaluated structural design, manufacturability, mechanical properties, cellular functions structures compared to currently available cages. In vitro tests...
Background and objective: Cervical fusion with vertebral body screw (VBS)-plate systems frequently results in limited biomechanical stability. To address this issue, anterior transpedicular (ATPS) fixation has been developed applied preliminarily to multilevel spinal fusion, osteoporosis, three-column injury of the cervical spine. This study aimed compare differences between unilateral ATPS (UATPS), bilateral (BATPS), VBS using finite element analysis. Materials methods: A C6 corpectomy...
Significant prominence of iliac crests with a deep seated L5 vertebra can potentially interfere the screw trajectory when placing percutaneous pedicle screws (PPS) at lumbosacral segment. The objective this study was to investigate influence position in relation on accuracy placement screws. From Oct 2012 Sep 2014, 54 patients who underwent PPS L5-S1 segment were recruited. Patients divided into 2 groups: L5-Seated Group (L5-S Group, n = 34) including intercrest lines passing through L4 or...
Objective. The purpose of this study was to investigate the feasibility and clinical efficacy percutaneous bilateral endoscopy technique (microendoscopic trans-Kambin’s triangle lumbar interbody fusion + endoscopic transforaminal decompression spinal canal, ME-TKT-LIF+ PETD) in treatment degenerative diseases. Methods. From May 2016 September 2018, 29 patients (16 males 13 females) who suffered from neurologic symptoms due spine disease underwent were enrolled. A microendoscope used for...
Degenerative changes of endplates in older patients and tilting vertebral body lumbosacral lordosis could make an accurate identification for the Cobb measurement difficult. Pedicles have been proposed as alternative landmarks because they are usually better visualized, offer similar clinical validity to endplates. The objective this study was investigate reliability pedicle method degenerative lumbar scoliosis compare it with traditional endplate method.Two hundred eighty-four radiographs...
Purpose To describe the clinical significance of prompt, adequate, and targeted intravenous antibiotic (IV antibiotic) therapy in successful management spinal epidural abscess (SEA) associated with Streptococcus intermedius ( S. ) infection. Case description SEA is a rare, but catastrophic infection that may result high risk permanent neurological disability. A 52-year-old Chinese female patient was presented to emergency department due 2 years low back pain 3 days decreased muscle strength...
The combination of screw fixation and cage can provide stability in lumbar interbody fusion (LIF), which is an important technique to treat degeneration diseases. As the narrow surface developed oblique lateral (OL-LIF), should be improved at same time. We used finite element (FE) method investigate biomechanics response by three different ways OL-LIF.Using a validated FE model, OL-LIF with 3 fixations was simulated, including percutaneous transverterbral (PTVS) fixation, cortical bone...