A5100347212- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Autophagy in Disease and Therapy
- Epigenetics and DNA Methylation
- Hippo pathway signaling and YAP/TAZ
- Neurogenesis and neuroplasticity mechanisms
- Cancer-related molecular mechanisms research
- Nerve injury and regeneration
- Lung Cancer Treatments and Mutations
- Cancer-related gene regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- MicroRNA in disease regulation
- Spinal Cord Injury Research
- Neuroscience and Neuropharmacology Research
- Circular RNAs in diseases
- Axon Guidance and Neuronal Signaling
- Lung Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Cancer, Lipids, and Metabolism
- Cancer Genomics and Diagnostics
- Wnt/β-catenin signaling in development and cancer
- Olfactory and Sensory Function Studies
- Respiratory Support and Mechanisms
- Systemic Lupus Erythematosus Research
- PI3K/AKT/mTOR signaling in cancer
Hangzhou Medical College
2017-2025
Zhejiang Provincial People's Hospital
2016-2025
Hangzhou First People's Hospital
2021-2025
Westlake University
2023-2025
Harbin Medical University
2013-2025
Wenzhou Medical University
2014-2025
Shanghai Jiao Tong University
2011-2025
University of South China
2017-2025
Hunan Children's Hospital
2025
First Affiliated Hospital of Guangzhou Medical University
2017-2025
Hepatocellular carcinoma (HCC) is one of the paramount causes cancer-related death worldwide. Despite recent advances have been made in clinical treatments HCC, general prognosis patients remains poor. Therefore, it imperative to develop a less toxic and more effective therapeutic strategy. Currently, series cellular, molecular, pharmacological experimental approaches were utilized address unrecognized characteristics disulfiram (DSF), pursuing goal repurposing DSF for cancer therapy. We...
Aims: The N6-methyladenosine (m6A) modification plays an important role in various biological processes, but its atherosclerosis remains unknown. aim of this study was to investigate the and mechanism m6A endothelial cell inflammation influence on development. Methods: We constructed a stable TNF-α-induced model assessed changes expression modification-related proteins identify major factors involved process. m6A-modified mRNAs were identified by methylated RNA immunoprecipitation (RIP)...
Ferroptosis is a newly discovered form of non-apoptotic regulated cell death and characterized by iron-dependent lipid peroxidation. Due to the enhanced dependence on iron in cancer cells, induction ferroptosis becoming promising therapeutic strategy. However, precise underlying molecular mechanism regulation process remains largely unknown. In present study, we demonstrate that protein Frataxin (FXN) key regulator modulating homeostasis mitochondrial function. Suppression FXN expression...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is an extremely lethal cancer with limited treatment options. Cisplatin (DDP) used as a mainstay of chemotherapeutic agents in combination other drugs or radiotherapy for PDAC therapy. However, DDP exhibits severe side-effects that can lead to discontinuation therapy, and the acquired drug resistance tumor cells presents serious clinical obstacles. Therefore, it imperative develop more effective less toxic therapeutic strategy. We others have...
The ability to form precise, episodic memories develops with age, young children only able gist-like that lack precision. cellular and molecular events in the developing hippocampus underlie emergence of episodic-like memory are unclear. In mice, absence a competitive neuronal engram allocation process immature precluded formation sparse engrams precise until fourth postnatal week, when inhibitory circuits mature. This age-dependent shift precision involved functional maturation...
purpose. To examine baseline measurements of accommodative lag, phoria, reading distance, amount near work, and level myopia as risk factors for progression their interaction with treatment over 3 years, in children enrolled the Correction Myopia Evaluation Trial (COMET). methods. COMET 469 ethnically diverse (ages, 6–11 years) between −1.25 −4.50 D. They were randomly assigned to either progressive addition lenses (PALs) a +2.00 (n = 235) or single vision (SVLs; n 234), conventional...
The orientation of mitotic cleavage regulates neurogenesis during neural development. We examined the dividing progenitor cells in subventricular zone (SVZ) adult rats subjected to stroke. In nonstroke rats, 55% were oriented horizontally, whereas 40% vertically. Horizontal and vertical orientations produce asymmetric symmetric divisions, respectively. Four days after stroke, number increased twofold, proportion significantly ( p < 0.01) from before stroke 60%. Fourteen percentage was...
Abstract Targeting autophagy may serve as a promising strategy for cancer therapy. Ganoderma lucidum polysaccharide (GLP) has been shown to exert anti-cancer effects. However, the underlying mechanisms remain elusive. Whether GLP regulates in never reported. In this study, induced initiation of colorectal (CRC) HT-29 and HCT116 cells, evidenced by enhanced level LC3-II protein, GFP-LC3 puncta, increased formation double membrane vacuoles. treatment caused marked increase p62 expression....
Central nervous system (CNS) regeneration with central neuronal connections and restoration of synaptic has been a long-standing worldwide problem and, to date, no effective clinical therapies are widely accepted for CNS injuries. The limited regenerative capacity the results from growth-inhibitory environment that impedes regrowth axons. neural tissue engineering attracted extensive attention multi-disciplinary scientists in recent years, many studies have carried out develop cell-...
Acute ischemic stroke (AIS) is the most common type of cerebrovascular disease and a leading cause disability death worldwide. Recently, study suggested that transformation microglia from pro-inflammatory M1 state to anti-inflammatory tissue-reparative M2 phenotype may be an effective therapeutic strategy for stroke. Celastrol, traditional oriental medicine, have neuroprotective effects. However, underlying mechanisms remain unknown. We first determined expression levels inflammatory factors...
African swine fever virus (ASFV), the etiological agent of (ASF), a hemorrhagic domestic pigs, has devastating consequences for pig farming industry. More than 1,000,000 pigs have been slaughtered since 3 August 2018 in China. However, vaccines or drugs ASF yet to be developed. As such, rapid test that can accurately detect ASFV on-site is important timely implementation control measures. In this study, we developed combines recombinase polymerase amplification (RPA) p72 gene with lateral...
YAP (yes-associated protein), a key transcriptional co-factor that is negatively regulated by the Hippo pathway, crucial for development and size control of multiple organs, including liver. However, its role in brain remains unclear. Here, we provide evidence YAP regulation mouse neocortical astrocytic differentiation proliferation. was undetectable neurons, but selectively expressed neural stem cells (NSCs) astrocytes. NSCs required differentiation, with no apparent self-renewal or...
Axonal degeneration is a common pathological feature in many acute and chronic neurological diseases such as spinal cord injury (SCI). SARM1 (sterile alpha TIR motif-containing 1), the fifth TLR (Toll-like receptor) adaptor, has diverse functions immune nervous systems, recently been identified key mediator of Wallerian (WD). However, detailed after SCI still remain unclear. Methods: Modified Allen's method was used to establish contusion model mice. Furthermore, address function SCI,...
Our understanding of the mechanisms underlying process in Alzheimer's disease (AD) is far from completion and new therapeutic targets are urgently needed. Recently, link between dementia diabetes mellitus (DM) prompted us to search for strategies glucose metabolism regulators neurodegeneration. Previous studies have indicated that fibroblast growth factor 21 (FGF21), an attractive potential treatment DM, may exert diverse effects central nervous system. However, specific biological function...
Yes-associated protein (YAP) transcriptional coactivator is negatively regulated by the Hippo pathway and functions in controlling size of multiple organs, such as liver during development. However, it not clear whether YAP signaling participates process formation glia scars after spinal cord injury (SCI). In this study, we found that was upregulated activated astrocytes C57BL/6 male mice SCI a pathway-dependent manner. Conditional knockout (KO) yap significantly inhibited astrocytic...
Globally, dental caries is the most prevalent chronic oral disease and affects roughly half of all children. The aim this report was to use metagenomic analyses investigate relationship between microbiome in preschool A total 25 preschoolers, aged 3 5 years old with severe early childhood (ECC), 19 age-matched, caries-free children as controls were recruited. Saliva samples collected from participants subjected analyses, whereby microbial communities investigated. revealed substantial...
Abstract Background PVT1 has emerged as an oncogene in many tumor types. However, its role Barrett’s esophagus (BE) and esophageal adenocarcinoma (EAC) is unknown. The aim of this study was to assess the BE/EAC progression uncover therapeutic value against EAC. Methods expression assessed by qPCR normal, BE, EAC tissues statistical analysis performed determine association (stage, metastases, survival). antisense oligonucleotides (ASOs) were tested for their antitumor activity vitro vivo....