A5042189116- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Meningioma and schwannoma management
- Management of metastatic bone disease
- Pituitary Gland Disorders and Treatments
- Cancer Genomics and Diagnostics
- Nanoplatforms for cancer theranostics
- Epigenetics and DNA Methylation
- Radiomics and Machine Learning in Medical Imaging
- Neurogenesis and neuroplasticity mechanisms
- Head and Neck Surgical Oncology
- Cerebrospinal fluid and hydrocephalus
- Neurosurgical Procedures and Complications
- Photodynamic Therapy Research Studies
- Spine and Intervertebral Disc Pathology
- Cancer, Hypoxia, and Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Spinal Fractures and Fixation Techniques
- Anesthesia and Pain Management
- Vascular Malformations Diagnosis and Treatment
- Lung Cancer Research Studies
- Chromatin Remodeling and Cancer
- MicroRNA in disease regulation
- Palliative Care and End-of-Life Issues
- Traumatic Brain Injury and Neurovascular Disturbances
Henry Ford Health System
2007-2025
Michigan United
2024
Henry Ford Hospital
2005-2024
Neurological Surgery
2014-2023
Oxford University Press (United Kingdom)
2020
Memorial Sloan Kettering Cancer Center
2017-2018
Cornell University
2018
University of Dhaka
2013
Ford Motor Company (United States)
2005
National Institute of Neurological Disorders and Stroke
2004
Molecular mechanisms underlying the role of statins in induction brain plasticity and subsequent improvement neurologic outcome after treatment stroke have not been adequately investigated. Here, we use both vivo vitro studies to investigate potential roles two prominent factors, vascular endothelial growth factor (VEGF) brain-derived neurotrophic (BDNF), mediating with atorvastatin. Treatment adult mice atorvastatin daily for 14 days, starting at 24 hours MCAO, shows significant functional...
In the adult rodent, stroke induces an increase in endogenous neural progenitor cell (NPC) proliferation subventricular zone (SVZ) and neuroblasts migrate towards ischemic boundary. We investigated role of stromal cell-derived factor 1α (SDF-1α) mediating NPC migration after stroke. found that cultured NPCs harvested from normal SVZ, when they were overlaid onto brain slices, exhibited significantly ( P > 0.01) increased (67.2 ± 25.2 μm) compared with on slices (29.5729.5 μm)....
The orientation of mitotic cleavage regulates neurogenesis during neural development. We examined the dividing progenitor cells in subventricular zone (SVZ) adult rats subjected to stroke. In nonstroke rats, 55% were oriented horizontally, whereas 40% vertically. Horizontal and vertical orientations produce asymmetric symmetric divisions, respectively. Four days after stroke, number increased twofold, proportion significantly ( p < 0.01) from before stroke 60%. Fourteen percentage was...
The detection of somatic mutations in cell-free DNA (cfDNA) from liquid biopsy has emerged as a noninvasive tool to monitor the follow-up cancer patients. However, significance cfDNA clinical utility remains uncertain patients with brain tumors, primarily because limited sensitivity detect real tumor-specific mutations. This unresolved challenge prevented accurate glioma approaches.Genome-wide methylation profiling tumor tissue and serum patients.Here, we developed approach profile status...
Abstract Recurrence of meningiomas is unpredictable by current invasive methods based on surgically removed specimens. Identification patients likely to recur using noninvasive approaches could inform treatment strategy, whether intervention or monitoring. In this study, we analyze the DNA methylation levels in blood (serum and plasma) tissue samples from 155 meningioma patients, compared other central nervous system tumor non-tumor entities. We discover markers unique use artificial...
Ischemic stroke induces neurogenesis in the subventricular zone (SVZ), and newly generated neurons SVZ migrate toward ischemic boundary. However, characteristics of migrating cells have not been investigated after stroke. Using time-lapse imaging both organotypic brain slice cultures, we measured dynamics cell division migration adult rats subjected to In normal slices, primarily migrated dorsally ventrally along lateral ventricular surface. laterally striatal Cultured stroke-derived...
Abstract BACKGROUND Despite major advances in radiation and systemic treatments, surgery remains a critical step the multidisciplinary treatment of metastatic spinal cord tumors. OBJECTIVE To describe indications, rationale, technique “hybrid therapy” (separation concomitant spine stereotactic radiosurgery [SRS]) along with practical nuances. METHODS Separation describes posterolateral approach for circumferential epidural decompression stabilization. The goal is to decompress cord,...
Novel methods in predicting survival patients with spinal metastases may help guide clinical decision-making and stratify treatments regarding surgery vs palliative care.To evaluate whether the frailty/sarcopenia paradigm is predictive of morbidity undergoing for metastasis.A total 271 from 4 tertiary care centers who had undergone metastasis were identified. Frailty/sarcopenia was defined by psoas muscle size. Survival hazard ratios calculated using multivariate analysis, variables...
Background: Fluorescence-guided surgery (FGS) using 5-aminolevulic acid (5-ALA) is a widely used strategy for delineating tumor tissue from surrounding brain intraoperatively during high-grade glioma (HGG) resection. 5-ALA reaches peak plasma levels ~4 h after oral administration and currently approved by the FDA use 2–4 prior to induction anesthesia. Objective: To demonstrate that there adequate intraoperative fluorescence in cases undergoing more than 4 compare survival radiological...
OBJECTIVE Recent studies have demonstrated that periventricular tumor location is associated with poorer survival and near the ventricle limits extent of resection. This finding may relate to perception ventricular entry leads further complications thus surgeons choose perform less aggressive resection in these areas. However, there little support for this view literature. study seeks determine whether more during craniotomy brain METHODS A retrospective analysis patients who underwent at...
Abstract Background DNA methylation abnormalities are pervasive in pituitary neuroendocrine tumors (PitNETs). The feasibility to detect methylome alterations circulating cell-free (cfDNA) has been reported for several central nervous system (CNS) but not across PitNETs. aim of the study was use liquid biopsy (LB) approach PitNET-specific signatures differentiate these from other sellar diseases. Methods We profiled cfDNA (EPIC array) 59 serum and 41 plasma LB specimens patients with PitNETs...
INTRODUCTION: Determining true recurrence versus necrosis alone after previous radiotherapy (RT) for brain metastasis based on imaging is challenging. Accurate diagnosis critical to patient management, as further RT contraindicated in the setting of radiation without tumor (TUM-). METHODS: Rates intraoperative frozen section pathology reporting +/- (TUM+) or (TUM-) were examined patients undergoing resection presumed RBM prior same-site RT. All cases prospectively enrolled a...
BACKGROUND: Laser interstitial thermal therapy (LITT) for glioblastoma (GBM) has been reserved poor surgical candidates and deep “inoperable” lesions. We present the first reported series of LITT surgically accessible recurrent GBM (rGBM) that would otherwise be treated with resection. OBJECTIVE: To evaluate use unifocal, lobar, first-time rGBM compared a similar cohort. METHODS: A retrospective institutional database was used to identify patients who underwent or resection between 2013...
ABSTRACT Objective Intrathecal fluorescein (IF) is effective for localizing nasal cerebrospinal fluid (CSF) leaks along the skull base during endoscopic exploration, with largest studies reporting sensitivities ranging from 66%–93%. Due to reports of intraoperative and postoperative neurologic complications such as seizures paralysis, surgeons often dilute inject it intrathecally slowly over a variable amount time. However, no study has assessed whether rapid IF administration causes...
Angiogenesis promotes tumor growth and invasiveness in brain. Because brain injury often induces expression of angiogenic-promoting molecules, we hypothesize that oxidative insult induced by photodynamic therapy (PDT) could lead to an endogenous angiogenic response, possibly diminishing the efficacy PDT treatment tumors. Therefore, sought establish whether response within nontumored using Photofrin as a sensitizer at optical dose 140 J/cm2 was performed on normal rat (n = 30). Animals were...
Abstract Rodent adult subventricular zone (SVZ)‐derived progenitor cells abandon the rostral migratory stream (RMS)/olfactory complex postmiddle cerebral artery occlusion (MCAo) and migrate into compromised tissue, possibly playing a role in brain recovery. Using SVZ tissue explants from rat, we investigated of phosphoinositide 3‐kinase (PI3K) signal transduction pathway migration cells. Stroke significantly ( P < .01) increased speed (198 ± 39 μm/day) neuroblasts out compared with (99 20...