A5078923879- Head and Neck Surgical Oncology
- Sinusitis and nasal conditions
- Cerebrospinal fluid and hydrocephalus
- Pituitary Gland Disorders and Treatments
- Kruppel-like factors research
- Meningioma and schwannoma management
- Oral and Maxillofacial Pathology
- Bone Tumor Diagnosis and Treatments
- Ear and Head Tumors
- Nasal Surgery and Airway Studies
- Epigenetics and DNA Methylation
- Neuroendocrine Tumor Research Advances
- Salivary Gland Tumors Diagnosis and Treatment
- Allergic Rhinitis and Sensitization
- Glioma Diagnosis and Treatment
- Asthma and respiratory diseases
- Airway Management and Intubation Techniques
- Developmental Biology and Gene Regulation
- Neuroblastoma Research and Treatments
- Neurosurgical Procedures and Complications
- Tracheal and airway disorders
- Cleft Lip and Palate Research
- Spinal Fractures and Fixation Techniques
- Head and Neck Cancer Studies
- Teratomas and Epidermoid Cysts
Mayo Clinic
2024-2025
WinnMed
2024-2025
Henry Ford Health System
2022-2025
University of Pennsylvania
2021-2024
Michigan United
2023-2024
Henry Ford Hospital
2024
Macquarie University
2024
Northwestern University
2019-2023
Lurie Children's Hospital
2019-2022
Molecular Oncology (United States)
2016
A multifunctional gold (Au) nanorod (NR)-based nanocarrier capable of co-delivering small interfering RNA (siRNA) against achaete-scute complex-like 1 (ASCL1) and an anticancer drug (doxorubicin (DOX)) specifically to neuroendocrine (NE) cancer cells was developed characterized for combined chemotherapy siRNA-mediated gene silencing. The Au NR conjugated with (1) DOX, drug, via a pH-labile hydrazone linkage enable pH-controlled release, (2) polyarginine, cationic polymer complexing siRNA,...
Sinonasal mucosal melanoma has poor survival despite multimodality treatment. While the impact of immunotherapy (IT) on metastatic cutaneous is well-defined, there are relatively little data sinonasal melanoma. We sought to define outcomes in patients with A retrospective cohort study evaluated treated IT during their overall treatment strategy for SNMM. Patient demographics, treatment, and were recorded. 52 had SNMM from 2000 2022, an average age 69.1 ± 11.9 years. The most common was...
BACKGROUND:In this study, we identified key discrete clinical and technical factors that may correlate with primary reconstructive success in endoscopic skull base surgery (ESBS). METHODS: ESBS cases intraoperative cerebrospinal fluid (CSF) leaks at four tertiary academic rhinology programs were retrospectively reviewed. Logistic regression associated surgical outcomes by defect subsite (anterior cranial fossa [ACF], suprasellar [SS], purely sellar, posterior [PCF]). RESULTS: Of 706 patients...
Objectives Endoscopic sinus surgery (ESS) is often necessary when managing odontogenic sinusitis (ODS), but ESS extent for ODS with extramaxillary involvement has been incompletely studied. This study compared outcomes after wide maxillary antrostomy (MA) alone versus complete frontal involvement. Methods A multicenter prospective cohort was conducted on patients uncomplicated (no extrasinus spread) who underwent computed tomography demonstrated maxillary, anterior ethmoid (AE), and...
Notch1-3 are transmembrane receptors that appear to be absent in medullary thyroid cancer (MTC). Previous research has shown induction of Notch1 a tumor-suppressor effect MTC cell lines, but little is known about the biologic consequences Notch3 activation for progression disease. We elucidate role by genetic (doxycycline-inducible intracellular domain) and pharmacologic [AB3, novel histone deacetylase (HDAC) inhibitor] approaches. find overexpression leads dose-dependent reduction...
The 22-item Sino-Nasal Outcome Test (SNOT-22) and 12-item Patient Reported Outcomes in Chronic Rhinosinusitis (CRS-PRO) instrument are validated patient-reported outcomes measures CRS. In this study we assess the correlation of these with type 2 (T2) biomarkers before after endoscopic sinus surgery (ESS).
Olfactory neuroblastoma (ONB) is a rare sinonasal malignancy primarily treated with surgery. For tumors arising from the olfactory area, traditional treatment involves transcribriform resection of anterior cranial fossa. Surgery can be performed unilateral or bilateral depending on extent involvement; however, there are currently no studies comparing outcomes between two. Prospective and retrospective data primary ONB patients were collected multicenter registry involving eight academic...
ABSTRACT Objective Intrathecal fluorescein (IF) is effective for localizing nasal cerebrospinal fluid (CSF) leaks along the skull base during endoscopic exploration, with largest studies reporting sensitivities ranging from 66%–93%. Due to reports of intraoperative and postoperative neurologic complications such as seizures paralysis, surgeons often dilute inject it intrathecally slowly over a variable amount time. However, no study has assessed whether rapid IF administration causes...
<title>Abstract</title> Objectives Tumor factors such as subsite and stage impact the risk of lymph node metastasis (LNM) overall in sinonasal squamous cell carcinoma (SNSCC). We sought to identify rates patients presenting with or without clinical LNM for different tumor subsites stages surgically-treated SNSCC, determine concordance between pathologic after neck dissection (ND), predictors occult LNM. Methods The National Cancer Database was queried SNSCC from 2004–2016. For LNM,...
Pouchitis is a common and troublesome condition, disturbed microbiological flora mucosal blood flow in the pouch have been suggested as possible causes. Laser Doppler flowmetry (LDF) has used successfully to measure gastric colonic perfusion humans. The aim of this study was evaluate effect intervention with probiotics on ileal inflammation pouch, assessed by endoscopy, histology, fecal calprotectin LDF.A fermented milk product (Cultura; 500 ml) containing live lactobacilli (La-5)...
Abstract Objective To evaluate recurrence patterns and survival after among patients with sinonasal mucosal melanoma (SNMM). Methods This was a multi‐institutional retrospective review from seven U.S. institutions of SNMM 1991 to 2022. Recurrence categorized as local, regional, distant, or multifocal. Kaplan‐Meier tests were used disease‐free (DFS), overall (OS), post‐recurrence (PRS) reported standard errors (SE) log‐rank testing for comparison. Cox‐regression further used, hazard ratios...
Unilateral sphenoid sinus opacification on computed tomography is caused by a variety of pathologies including inflammatory and infectious sinusitis, benign malignant tumors, encephaloceles. The purpose this study was to report craniofacial pain locations outcomes in unilateral sinusitis (USS) patients who underwent endoscopic surgery (ESS).
A case of disseminated malignant melanoma with generalized melanosis the skin and other tissues, melanuria, melanoptysis, a dark brown blood serum is reported. The reticuloendothelial system contained large amounts melanin pigment. Lysis degenerating pigment‐loaded cells in peripheral vessels seemed to be considerable importance pigmentation tissues. Focal capillary endothelium perivascular deposition pigment macrophages and, occasionally, cells, was noted. Single cell metastases contributed...
Background: Pouchitis is a common and troublesome condition in patients operated on with ileal-pouch-anal-anastomosis (IPAA). A disturbed mucosal perfusion the pouch has been suggested as possible cause. Laser Doppler flowmetry (LDF) used successfully to measure gastric colonic humans. In previous study, we demonstrated reduced distal part of pouch, during probiotic intervention, examined by LDF measurement. The aim present study was confirm our results much larger material, compare...
Objectives Unilateral clear thin rhinorrhea (UCTR) can be concerning for a nasal cerebrospinal fluid (CSF) leak. Beta‐2 transferrin electrophoresis has been the gold standard initial non‐invasive confirmatory testing CSF rhinorrhea, but there issues with collection and errors. Ipratropium bromide spray (IBNS) is highly effective at reducing rhinitis‐related should presumably not resolve rhinorrhea. This study assessed whether different clinical features IBNS response helped predict presence...
Abstract Medullary thyroid cancer ( MTC ) is an aggressive neuroendocrine tumor NET ). Previous research has shown that activation of N otch signaling a suppressor role in s. The potential therapeutic effect thiocoraline on the pathway cell line TT was investigated. Thiocoraline isolated from marine bacterium V errucosispora sp. MTT assay (3‐[4, 5‐dimethylthiazole‐2‐yl]‐2, 5‐diphenyltetrazolium bromide) used to determine IC 50 value and measure proliferation. W estern blot revealed...
Mometasone-eluting stents (MES) have demonstrated improvement in short-term endoscopic outcomes and reduce short- to medium-term rescue interventions. Their effect on the local inflammatory environment, longer-term patient-reported outcomes, radiographic severity not been studied.
Abstract Objective Functional endoscopic sinus surgery is a commonly performed otolaryngologic procedure that often uses the microdebrider device for tissue removal. Given ubiquitous nature of instrument, we sought to better define patterns failure using postmarket surveillance openFDA database. Methods The database was queried all microdebrider‐related adverse events from January 1, 2000 November 2020. Descriptive information on and any associated patient injury compiled. Reports not...
Autonomic nerve densities were equivalent in posterior nasal (PNN), posterolateral (PLNN), and anterior ethmoid nerves (AEN). Rhinitis studies should explore the utility of PLNN and/or AEN transection over PNN alone.