A5016280841- Head and Neck Surgical Oncology
- Sinusitis and nasal conditions
- Ear and Head Tumors
- Pituitary Gland Disorders and Treatments
- Cerebrospinal fluid and hydrocephalus
- Oral and Maxillofacial Pathology
- Nasal Surgery and Airway Studies
- Bone Tumor Diagnosis and Treatments
- Tracheal and airway disorders
- Meningioma and schwannoma management
- Head and Neck Cancer Studies
- Allergic Rhinitis and Sensitization
- Anesthesia and Pain Management
- Opioid Use Disorder Treatment
- Asthma and respiratory diseases
- Lymphoma Diagnosis and Treatment
- Dental Anxiety and Anesthesia Techniques
- Spinal Fractures and Fixation Techniques
- Airway Management and Intubation Techniques
- Salivary Gland Tumors Diagnosis and Treatment
- Teratomas and Epidermoid Cysts
- Sarcoma Diagnosis and Treatment
- COVID-19 and healthcare impacts
- Obstructive Sleep Apnea Research
- Cardiac, Anesthesia and Surgical Outcomes
Kaiser Permanente Oakland Medical Center
2016-2025
Kaiser Permanente Redwood City Medical Center
2022-2025
University of Pennsylvania
2021-2024
Michigan State University
2021
Salk Institute for Biological Studies
2018-2019
University of California, Irvine
2016
Comparative analyses of neuronal phenotypes in closely related species can shed light on changes occurring during evolution. The study post-mortem brains nonhuman primates (NHPs) has been limited and often does not recapitulate important species-specific developmental hallmarks. We utilize induced pluripotent stem cell (iPSC) technology to investigate the development cortical pyramidal neurons following migration maturation cells grafted developing mouse cortex. Our results show differential...
Sinonasal mucosal melanoma has poor survival despite multimodality treatment. While the impact of immunotherapy (IT) on metastatic cutaneous is well-defined, there are relatively little data sinonasal melanoma. We sought to define outcomes in patients with A retrospective cohort study evaluated treated IT during their overall treatment strategy for SNMM. Patient demographics, treatment, and were recorded. 52 had SNMM from 2000 2022, an average age 69.1 ± 11.9 years. The most common was...
BACKGROUND:In this study, we identified key discrete clinical and technical factors that may correlate with primary reconstructive success in endoscopic skull base surgery (ESBS). METHODS: ESBS cases intraoperative cerebrospinal fluid (CSF) leaks at four tertiary academic rhinology programs were retrospectively reviewed. Logistic regression associated surgical outcomes by defect subsite (anterior cranial fossa [ACF], suprasellar [SS], purely sellar, posterior [PCF]). RESULTS: Of 706 patients...
Objectives Endoscopic sinus surgery (ESS) is often necessary when managing odontogenic sinusitis (ODS), but ESS extent for ODS with extramaxillary involvement has been incompletely studied. This study compared outcomes after wide maxillary antrostomy (MA) alone versus complete frontal involvement. Methods A multicenter prospective cohort was conducted on patients uncomplicated (no extrasinus spread) who underwent computed tomography demonstrated maxillary, anterior ethmoid (AE), and...
Abstract Objective To evaluate recurrence patterns and survival after among patients with sinonasal mucosal melanoma (SNMM). Methods This was a multi‐institutional retrospective review from seven U.S. institutions of SNMM 1991 to 2022. Recurrence categorized as local, regional, distant, or multifocal. Kaplan‐Meier tests were used disease‐free (DFS), overall (OS), post‐recurrence (PRS) reported standard errors (SE) log‐rank testing for comparison. Cox‐regression further used, hazard ratios...
Unilateral sphenoid sinus opacification on computed tomography is caused by a variety of pathologies including inflammatory and infectious sinusitis, benign malignant tumors, encephaloceles. The purpose this study was to report craniofacial pain locations outcomes in unilateral sinusitis (USS) patients who underwent endoscopic surgery (ESS).
Lymphoma is the most common neck mass malignancy in adults but can present diagnostic challenges due to controversy surrounding best initial biopsy approach. In this study, authors characterize pathway with lymphoma (or leukemia) presenting initially as a and examine procedures required for diagnosis large community-based practice setting. Using data from retrospective cohort of 4103 referred otolaryngology (5% found be malignant), identified subset examined time number type biopsies...
A 40-year-old male patient presents with a 2-month history of pruritic, nontender irritation at the nasal sills. What is your diagnosis?
<title>Abstract</title> Objectives Tumor factors such as subsite and stage impact the risk of lymph node metastasis (LNM) overall in sinonasal squamous cell carcinoma (SNSCC). We sought to identify rates patients presenting with or without clinical LNM for different tumor subsites stages surgically-treated SNSCC, determine concordance between pathologic after neck dissection (ND), predictors occult LNM. Methods The National Cancer Database was queried SNSCC from 2004–2016. For LNM,...
Dupilumab was the first biologic approved to treat chronic rhinosinusitis with nasal polyps (CRSwNP). While risk of adverse events in phase-III clinical trials low, dupilumab-associated reactions (DAR) real-world use is unknown and potentially under-reported. We aimed evaluate DAR for CRSwNP treatment (CRSwNP-tx) using FDA Adverse Event Reporting System (FAERS).Retrospective database study.FAERS queried from 2019Q1 2021Q2. Individual (iDAR) were categorized quantitatively compared between...
Objectives/Hypothesis To evaluate the impact of resident involvement during thyroid surgery on 30‐day postoperative complications. Study Design Retrospective cohort study. Methods All patients who underwent in 2011 were identified from American College Surgeons National Surgical Quality Improvement Program database. Patient demographics, perioperative details, surgery, and complications extracted. Propensity score analysis was used to match nonresident cases. Univariate multivariate...
We describe the incidence and characteristics of patients with head neck injuries from rock climbing who present to United States emergency departments evaluate predictors hospitalization.The National Electronic Injury Surveillance System (NEISS) database was queried for head, face, mouth, neck, ear under product code "mountain climbing" years 2009 2018. Demographics, injury characteristics, disposition data were reviewed. Data evaluated using chi-square analysis Cochran-Mantel-Haenszal odds...
Abstract Objective Functional endoscopic sinus surgery is a commonly performed otolaryngologic procedure that often uses the microdebrider device for tissue removal. Given ubiquitous nature of instrument, we sought to better define patterns failure using postmarket surveillance openFDA database. Methods The database was queried all microdebrider‐related adverse events from January 1, 2000 November 2020. Descriptive information on and any associated patient injury compiled. Reports not...
Purpose: Endoscopic surgeries, such as dacryocystorhinostomy (DCR), are increasingly performed for orbital and lacrimal conditions. This study describes compares recent trends in endoscopic DCR with open, or external, the United States (US). Methods: Medicare-Part-B National Summary data files were analyzed from 2000 to 2015 temporal geographic external DCR. Medicare Physician Other Supplier public use detailing provider information collected 2012 2015. Results: Between 2015, number of DCRs...
Sinonasal lymphoma (SL) is a heterogeneous, underrecognized neoplastic disorder with limited outcomes data. We sought to better define by subtype and treatment at 2 referral centers over the past decades.Demographics, clinicopathologic data, for patients treated SL were queried from January 1, 2000 December 31, 2021 tertiary academic medical centers.Eighty-four included, an average age diagnosis of 63.4 ± 15 years. There 34 females (40.5%). The majority had Eastern Cooperative Oncology Group...
Abstract Objectives The use of topical corticosteroids to manage postoperative sinonasal symptoms after endoscopic skull base surgery (ESBS) has not been well studied. We quantified long‐term impact steroid irrigations (SIs) on quality life patients ESBS. Methods Retrospective review at the University Pennsylvania undergoing ESBS from 2010 2019. Data patient demographics and treatment with nasal saline irrigation twice daily without dissolved steroids (mometasone or budesonide) was...
Aspirin-exacerbated respiratory disease (AERD) refers to the combination of asthma, chronic rhinosinusitis with nasal polyposis (CRSwNP), and acute tract reactions ingestion aspirin nonsteroidal anti-inflammatory drugs (NSAIDs). There have been no in literature investigating diagnostic delay AERD. We aimed investigate whether diagnosis AERD is associated poorer clinical outcomes as well characterize role specialty evaluation diagnosis.We conducted a retrospective observational study 254...