A5056539671- Glioma Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
- Epigenetics and DNA Methylation
- Meningioma and schwannoma management
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Growth Hormone and Insulin-like Growth Factors
- Cancer Genomics and Diagnostics
- Thyroid Disorders and Treatments
- Pancreatic function and diabetes
- Diabetes Management and Research
- Trace Elements in Health
- Adrenal and Paraganglionic Tumors
- Regulation of Appetite and Obesity
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes Treatment and Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Chromatin Remodeling and Cancer
- Radiomics and Machine Learning in Medical Imaging
- Sarcoma Diagnosis and Treatment
- Thyroid Cancer Diagnosis and Treatment
- Peroxisome Proliferator-Activated Receptors
- Congenital heart defects research
- Cardiovascular Effects of Exercise
- Liver Disease Diagnosis and Treatment
Michigan State University
2023-2025
Neurological Surgery
2023-2025
Universidade de Santiago de Compostela
2025
Henry Ford Health System
2018-2024
Henry Ford Hospital
2023
Universidad Andrés Bello
2021
Michigan United
2019
Cedars-Sinai Medical Center
2003-2016
University of Southern California
2014-2015
Universidade de São Paulo
2014-2015
The detection of somatic mutations in cell-free DNA (cfDNA) from liquid biopsy has emerged as a noninvasive tool to monitor the follow-up cancer patients. However, significance cfDNA clinical utility remains uncertain patients with brain tumors, primarily because limited sensitivity detect real tumor-specific mutations. This unresolved challenge prevented accurate glioma approaches.Genome-wide methylation profiling tumor tissue and serum patients.Here, we developed approach profile status...
Abstract Recurrence of meningiomas is unpredictable by current invasive methods based on surgically removed specimens. Identification patients likely to recur using noninvasive approaches could inform treatment strategy, whether intervention or monitoring. In this study, we analyze the DNA methylation levels in blood (serum and plasma) tissue samples from 155 meningioma patients, compared other central nervous system tumor non-tumor entities. We discover markers unique use artificial...
Insulin resistance is a powerful risk factor for Type 2 diabetes and constellation of chronic diseases, most commonly associated with obesity. We examined if factors other than obesity are more substantial predictors insulin sensitivity under baseline, nonstimulated conditions.Metabolic assessment was performed in healthy dogs (n = 90). Whole-body from euglycemic clamps (SICLAMP ) the primary outcome variable, measured independently by IVGTT 36). Adiposity MRI 90), glucose-stimulated...
Abstract Background DNA methylation abnormalities are pervasive in pituitary neuroendocrine tumors (PitNETs). The feasibility to detect methylome alterations circulating cell-free (cfDNA) has been reported for several central nervous system (CNS) but not across PitNETs. aim of the study was use liquid biopsy (LB) approach PitNET-specific signatures differentiate these from other sellar diseases. Methods We profiled cfDNA (EPIC array) 59 serum and 41 plasma LB specimens patients with PitNETs...
Human type 2 diabetes mellitus (T2DM) is often characterized by obesity-associated insulin resistance (IR) and β-cell function deficiency. Development of relevant large animal models to study T2DM important timely, because most existing have dramatic reductions in pancreatic no associated obesity IR, features that resemble more T1DM than T2DM. Our goal was create a canine model which IR occurs first, followed moderate reduction function, leading mild or impaired glucose tolerance. Lean dogs...
OBJECTIVE Pituitary adenomas (PAs) are common lesions that often present with endocrinopathy and/or visual symptoms. Classification of PAs has historically been based on functional status and histopathological staining anterior pituitary hormones. In 2017, the WHO revised classification PAs, establishing cell lineages identified by transcription factors (TFs) PIT1, TPIT, SF1. The clinical behavior PA subtypes TF typing, including growth patterns, response to treatment, recurrence rates, is...
Introduction: Stroke has an enormous impact on society, both socially and economically. It is the most common cause of admission prolonged stay in Neurology ward. Methods: We performed a cost-effectiveness analysis stroke treatment Complejo Hospitalario de Santiago Compostela, where patients are treated unit. Firstly, costs unit was carried out, which had not been done before. The were compared with those that would be incurred if disease without unit, verifying existence such implies...
This study examines the challenges in preventing Sexually Transmitted Infections (STIs) among young people and adolescents, emphasizing importance of educational strategies promoting sexual reproductive health. To conduct a precise analysis, following research question was defined: "What are main STIs how can help minimize these obstacles?" The general objective is to analyze STI prevention relevance for this group's Additionally, specific objectives were outlined: discuss concept STIs;...
Objective Insulin must move from the blood to interstitium initiate signaling, yet access may be impaired in cases of insulin resistance, such as obesity. This study investigated whether consuming a short‐ and long‐term high‐fat diet (HFD) impairs skeletal muscle, major site insulin‐mediated glucose uptake. Methods Male mongrel dogs were divided into three groups consisting control ( n = 16), short‐term 8), HFD 8). sensitivity was measured with intravenous tolerance tests. A hyperinsulinemic...
Elevated plasma free fatty acids (FFA) induce insulin resistance in skeletal muscle. Previously, we have shown that experimental induced by lipid infusion prevents the dispersion of through muscle, and hypothesized this would lead to an impairment moving from muscle interstitium. Thus, infused into our anesthetized canine model measured appearance lymph as a means sample interstitium under hyperinsulinemic euglycemic clamp conditions. Although lowered glucose rate both peripheral hepatic...
Abstract Background Distinct genome-wide methylation patterns cluster pituitary neuroendocrine tumors (PitNETs) into molecular groups associated with specific clinicopathological features. Here we aim to identify, characterize, and validate signatures that objectively classify PitNET groups. Methods Combining in-house publicly available data, conducted an analysis of the methylome profile a comprehensive cohort 177 (Panpit cohort) 20 nontumor specimens from gland. We also retrieved data...
Chordomas are tumors derived from cells that remnants of the notochord, particularly its proximal and distal extremes, they mainly midline represent approximately 1% all malignant bone 0.1 to 0.2% intracranial neoplasms. involving sellar region rare. Herein, we describe a 57-year-old male patient presenting with history retro-orbital headache, progressive loss vision, clinical features hypopituitarism, for over 2 months. During evaluation, CT scan revealed large contrast-enhancing...
To assess the cardiovascular features of Ullrich-Turner's syndrome using echocardiography and magnetic resonance imaging, to correlate them with phenotype karyotype patients. The diagnostic concordance between 2 methods was also assessed.Fifteen patients were assessed by imaging (cardiac chambers, valves, aorta). Their ages ranged from 10 28 (mean 16.7) years. analyzed in 11 or 25 metaphases peripheral blood lymphocytes, both.The most common phenotypic changes short stature spontaneous...
The hepatoportal area is an important glucohomeostatic metabolic sensor, sensing hypoglycemia, hyperglycemia, and hormones such as glucagon-like peptide-1 (GLP-1). We have reported previously that activation of sensors by intraportal infusion glucose GLP-1 or subcutaneous administration receptor activator exenatide improved glycemia independent corresponding changes in pancreatic hormones. It not clear whether this effect mediated via the portal vein (PV) direct action on liver itself. To...
To determine whether a selective increase of visceral adipose tissue content will result in insulin resistance. Sympathetic denervation the omental fat was performed under general inhalant anesthesia by injecting 6-hydroxydopamine lean mongrel dogs (n = 11). In conscious animal, whole-body sensitivity assessed minimal model (SI ) and euglycemic hyperinsulinemic clamp (SICLAMP ). Changes abdominal were monitored magnetic resonance. All assessments determined before (Wk0) 2 weeks (Wk2) after...
The purpose of this study was to identify echocardiographic parameters that allow distinguishing different levels cardiac dysfunction in aortic banded rats.Wistar male rats (90-100 g) were subjected banding (n=23) or a sham operation (n=12). following evaluated and used group into groups with similar characteristics using cluster analysis: absolute values after normalization body weight left ventricular end-diastolic diameter (LVDD) atrial systolic diameter; end-systolic (LVSD); LV ratio...