A5010974431- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Gallbladder and Bile Duct Disorders
- Neuroendocrine Tumor Research Advances
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastrointestinal Tumor Research and Treatment
- Colorectal Cancer Screening and Detection
- Pancreatitis Pathology and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Gastrointestinal disorders and treatments
- Lung Cancer Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Innovations in Medical Education
- Cancer-related gene regulation
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Treatments and Mutations
- Hippo pathway signaling and YAP/TAZ
- Biliary and Gastrointestinal Fistulas
- Nursing Roles and Practices
- Genetic factors in colorectal cancer
- Colorectal Cancer Surgical Treatments
- Renal cell carcinoma treatment
The University of Texas MD Anderson Cancer Center
2015-2024
Weatherford College
2020
Taiho Oncology (United States)
2020
Bristol-Myers Squibb (United States)
2020
Bayer (United States)
2020
Vifor Pharma (United States)
2020
Rogers (United States)
2020
Massachusetts General Hospital
2012-2019
Cancer Genetics (United States)
2019
Boston Back Bay Plastic Surgery
2019
We conducted a phase II trial of preoperative gemcitabine and cisplatin chemotherapy in addition to chemoradiation (Gem-Cis-XRT) pancreaticoduodenectomy (PD) for patients with stage I/II pancreatic adenocarcinoma.Chemotherapy consisted (750 mg/m(2)) (30 given every 2 weeks four doses. Chemoradiation weekly infusions (400 combined radiation therapy Gy 10 fractions administered over weeks) delivered 5 days per week. Patients underwent restaging 4 6 after completion and, the absence disease...
Gastric cancer is a heterogeneous cancer, making treatment responses difficult to predict. Here we show that identify two distinct molecular subtypes, mesenchymal phenotype (MP) and epithelial (EP), by analyzing genomic proteomic data. Molecularly, MP subtype tumors high integrity characterized low mutation rates microsatellite stability, whereas EP integrity. Clinically, the associated with markedly poor survival resistance standard chemotherapy, better sensitivity chemotherapy. Integrative...
Cancer stem cells (CSC) are purported to initiate and maintain tumor growth. Deregulation of normal cell signaling may lead the generation CSCs; however, molecular determinants this process remain poorly understood. Here we show that transcriptional coactivator YAP1 is a major determinant CSC properties in nontransformed esophageal cancer by direct upregulation SOX9. regulates transcription SOX9 through conserved TEAD binding site promoter. Expression exogenous vitro or inhibition its...
Patients with localized esophageal carcinoma have a 5-year survival rate of less than 20%. are often treated similarly (ie, preoperative chemoradiotherapy) but the outcomes vary greatly. Chemoradiotherapy and surgery can result in significant undesirable consequences. Currently, however, there no tools to help select optimum therapy. We hypothesized that gene expression profiling could provide clues biomarkers for selection therapy.Pretreatment endoscopic cancer biopsies from 19 patients (16...
BACKGROUND Reports are limited regarding clinical and pretreatment features that might predict a pathological complete response (pathCR) after treatment in patients with esophageal cancer (EC). This allow patient selection for different strategies. study examines the association of pathCR variables, overall survival (OS), recurrence‐free (RFS), patterns recurrence large cohort from single institution. METHODS The baseline 911 consecutive EC who were treated trimodality therapy January 2000...
The role of carbohydrate antigen (CA) 19-9 in the evaluation patients with resectable pancreatic cancer treated neoadjuvant therapy prior to planned surgical resection is unknown. We evaluated CA as a marker therapeutic response, completion therapy, and survival enrolled on two recently reported clinical trials.We analyzed radiographically adenocarcinoma head/uncinate process phase II trials chemoradiation. Patients without evidence disease progression following chemoradiation underwent...
Background Despite many attempts to establish pre-treatment prognostic markers understand the clinical biology of esophageal adenocarcinoma (EAC), validated biomarkers or parameters remain elusive. We generated and analyzed tumor transcriptome develop a practical biomarker signature in EAC. Methodology/Principal Findings Untreated endoscopic biopsy specimens were obtained from 64 patients undergoing surgery chemoradiation. Using DNA microarray technology, genome-wide gene expression...
Background: Fat grafting has become routine in plastic surgery because of low donor-site morbidity, a complication rate, and fast recovery time. The optimal technique, however, yet to be defined. Two critical variables are pressure shear, both defined as force divided by area. In this study, the authors examined effect shear on human fat grafts nude mouse model. Methods: For negative pressure, tumescent liposuction was performed fresh panniculectomy specimens. Suction either −15 inHg or −25...
Abstract Background PVT1 has emerged as an oncogene in many tumor types. However, its role Barrett’s esophagus (BE) and esophageal adenocarcinoma (EAC) is unknown. The aim of this study was to assess the BE/EAC progression uncover therapeutic value against EAC. Methods expression assessed by qPCR normal, BE, EAC tissues statistical analysis performed determine association (stage, metastases, survival). antisense oligonucleotides (ASOs) were tested for their antitumor activity vitro vivo....
OBJECTIVES The aim of this study was to assess the utility endoscopic ultrasound (EUS) with fine-needle aspiration (FNA) in patients unexplained common bile duct strictures after retrograde cholangiopancreatography (ERCP) and intraductal tissue sampling. METHODS Records were reviewed for all subjects undergoing EUS evaluation at our institution. 40 had either a final histologic diagnosis (24) or no evidence malignancy least 1 yr follow-up (16). RESULTS finding pancreatic head mass and/or an...
The lack of effective treatment for localized esosphageal cancer leads to poor patient outcome. Nuclear factor kappaB (NF-kappaB), a transcriptional factor, is constitutively activated or induced in esophageal and may influence outcomes.Pre- post-treatment specimens from patients enrolled onto clinical trial were studied the expression NF-kappaB protein it was correlated with histologic features, pathologic response, metastatic potential, overall survival (OS), disease-free (DFS).Forty-three...
OBJECTIVES The diagnosis of gastrointestinal (GI) graft-versus-host disease (GVHD) is based upon histologic findings in endoscopic mucosal biopsy specimens. portion the GI tract with highest diagnostic yield a topic debate. Our aim was to evaluate sensitivity simultaneous stomach, duodenum, and rectosigmoid establishing GVHD. METHODS We identified 112 patients who had biopsies within first 100 days following allogeneic hematopoietic stem cell transplantation (HSCT). GVHD defined...
To compare the efficacy of metal versus plastic stents for biliary strictures in patients with surgically resectable pancreatic cancer.The medical records at MD Anderson Caner Center from September 2001 to May 2004 were reviewed. Fifty-five identified have either a stent (13 patients, group A) or (42 B) and subsequently went surgery. These two groups compared regards number placed prior surgery, time period between last operative postoperative complications.Of 13 A, 12 had...