A5053919550- Occupational and environmental lung diseases
- Pleural and Pulmonary Diseases
- Cancer Research and Treatments
- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Medical Imaging and Pathology Studies
- Immune cells in cancer
- Gastric Cancer Management and Outcomes
- Ferroptosis and cancer prognosis
- Lung Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Myasthenia Gravis and Thymoma
- Immunotherapy and Immune Responses
- Esophageal and GI Pathology
- Genetic factors in colorectal cancer
- Tracheal and airway disorders
- RNA modifications and cancer
- Hippo pathway signaling and YAP/TAZ
- Epigenetics and DNA Methylation
- Esophageal Cancer Research and Treatment
- Lung Cancer Treatments and Mutations
- Metastasis and carcinoma case studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- MicroRNA in disease regulation
Honam University
2025
Baylor College of Medicine
2017-2024
Children's Cancer Center
2024
Seoul National University
2009-2023
Michael E. DeBakey VA Medical Center
2023
Boramae Medical Center
2023
Korea Institute of Oriental Medicine
2023
The University of Texas MD Anderson Cancer Center
2013-2018
National Cancer Center
2011-2016
Center for Systems Biology
2012
Abstract Purpose: The Cancer Genome Atlas (TCGA) project recently uncovered four molecular subtypes of gastric cancer: Epstein–Barr virus (EBV), microsatellite instability (MSI), genomically stable (GS), and chromosomal (CIN). However, their clinical significances are currently unknown. We aimed to investigate the relationship between prognosis patients with cancer. Experimental Design: Gene expression data from a TCGA cohort (n = 262) were used develop subtype prediction model, association...
Gastric cancer is a heterogeneous cancer, making treatment responses difficult to predict. Here we show that identify two distinct molecular subtypes, mesenchymal phenotype (MP) and epithelial (EP), by analyzing genomic proteomic data. Molecularly, MP subtype tumors high integrity characterized low mutation rates microsatellite stability, whereas EP integrity. Clinically, the associated with markedly poor survival resistance standard chemotherapy, better sensitivity chemotherapy. Integrative...
Activation of YAP1, a novel oncogene in the Hippo pathway, has been observed many cancers, including colorectal cancer. We investigated whether activation YAP1 is significantly associated with prognosis or treatment outcomes cancer.A gene expression signature reflecting was identified cancer cells, and patients were stratified into two groups according to this signature: activated (AYCC) inactivated (IYCC). Stratified five test cohorts evaluated determine effect on response cetuximab...
Immunotherapy has emerged as a promising anti-cancer treatment, however, little is known about the genetic characteristics that dictate response to immunotherapy. We develop transcriptional predictor of immunotherapy and assess its prediction in genomic data from ~10,000 human tissues across 30 different cancer types estimate potential The integrative analysis reveals two distinct tumor types: mutator type positively associated with immunotherapy, whereas chromosome-instable negatively it....
: Robotic surgery has evolved in urology, gynecology, and general seems to be an oncologically sound surgical approach. been infrequently reported for pulmonary lobectomy. The aim of this study is compare the outcomes our early experience performing robot-assisted lobectomy (RAL) with video-assisted thoracic (VATS) treatment non-small cell lung cancer.: Between February October 2009, 40 patients underwent RAL resectable cancer. dissection anatomic isolation hilar structures were performed...
Abstract Purpose: The Hippo pathway is a tumor suppressor in the liver. However, clinical significance of inactivation HCC not clearly defined. We analyzed genomic data from human and mouse tissues to determine relevance HCC. Experimental Design: gene expression Mst1/2−/− Sav1−/− mice identified 610-gene signature reflecting liver [silence (SOH) signature]. By integrating models with those tissues, we developed prediction model that could identify patients an inactivated used it test its...
// Hyun-Sung Lee 1,2 , Kwanbok 3 Hee-Jin Jang 1 Geon Kook 2 Jong-Lyul Park 4,5 Seon-Young Kim Sang-Bae Betty H. Johnson Jae Ill Zo 6 Ju-Seog 1,7 Yong Sun Department of Systems Biology, The University Texas MD Anderson Cancer Center, Houston, TX 77030, USA Center for Lung Cancer, Research Institute and Hospital, National Goyang, 410-769, Korea Biochemistry Molecular Medical Branch, Galveston, TX77555-1072, 4 Genomics KRIBB, Daejeon, 305-806, 5 Functional Genomics, Science Technology, Thoracic...
We generated a comprehensive atlas of the immunologic cellular networks within human malignant pleural mesothelioma (MPM) using mass cytometry. Data-driven analyses these high-resolution single-cell data identified 2 distinct subtypes MPM with vastly different composition, activation states, and function; spectrometry demonstrated differential abundance MHC-I -II neopeptides directly between subtypes. The clinical relevance this subtyping was investigated discriminatory molecular signature...
Abstract Purpose: To reconcile the heterogeneity of thymic epithelial tumors (TET) and gain deeper understanding molecular determinants TETs, we set out to establish a clinically relevant classification system for these tumors. Experimental Design: Molecular subgrouping TETs was performed in 120 patients from The Cancer Genome Atlas using multidimensional approach incorporating analyses DNA mutations, mRNA expression, somatic copy number alterations (SCNA), validated two independent cohorts....
Abstract Purpose: We report the results of a phase II, randomized, window-of-opportunity trial neoadjuvant durvalumab versus plus tremelimumab followed by surgery in patients with resectable malignant pleural mesothelioma (MPM; NCT02592551). Patients and Methods: The primary objective was alteration intratumoral CD8/regulatory T cell (Treg) ratio after combination immune checkpoint blockade (ICB) therapy. Secondary exploratory objectives included other changes tumor microenvironment,...
<h3>Objective</h3> Oesophageal squamous cell carcinoma (ESCC) is a heterogeneous disease with variable outcomes that are challenging to predict. A better understanding of the biology ESCC recurrence needed improve patient care. Our goal was identify small non-coding RNAs (sncRNAs) could predict likelihood after surgical resection and uncover potential molecular mechanisms dictate clinical heterogeneity. <h3>Design</h3> We developed robust prediction model for based on analysis expression...
Abstract Malignant pleural mesothelioma (MPM) is a rare but lethal cancer with high intratumor heterogeneity (ITH). A recent study in lung adenocarcinoma has developed clonal gene signature (ORACLE) from multiregional transcriptomic data and demonstrated prognostic values reproducibility. However, such strategy not been tested other types of ITH. We aimed to identify biomarkers multi-regional prognostically stratify MPM patients. generated RNA-seq dataset for 78 tumor samples obtained 26...
This study was aimed at developing and validating a quantitative multigene assay for predicting tumor recurrence after gastric cancer surgery.Gene expression data were generated from tissues of patients who underwent surgery (n = 267, training cohort). Genes whose significantly associated with activation YAP1 (a frequently activated oncogene in gastrointestinal cancer), 5-year recurrence-free survival, overall survival first identified as candidates prognostic genes (156 genes, P < 0.001)....
OBJECTIVESRespiratory failure from acute lung injury (ALI), respiratory distress syndrome (ARDS) and pneumonia are the major cause of morbidity mortality following an oesophagectomy for oesophageal cancer. This study was performed to investigate whether intraoperative corticosteroid can attenuate postoperative failure.
nc886 is a regulatory non-coding RNA (ncRNA) whose expression frequently silenced in malignancies. In the case of esophageal squamous cell carcinoma (ESCC), silencing associated with shorter survival patients, suggesting nc886's tumor suppressor role ESCC. However, this observation has not been complemented by an in-detail study about impact on gene and cellular phenotypes. Here we have shown that inhibits AKT, key protein renowned pro-survival pathway cancer. nc886-silenced cells (nc886-...