A5089143372- Occupational and environmental lung diseases
- Pleural and Pulmonary Diseases
- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- Medical Imaging and Pathology Studies
- Immune cells in cancer
- Osteoarthritis Treatment and Mechanisms
- Silk-based biomaterials and applications
- Ferroptosis and cancer prognosis
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer Research and Treatments
- Adipose Tissue and Metabolism
- Epigenetics and DNA Methylation
- Phagocytosis and Immune Regulation
- Metastasis and carcinoma case studies
- Viral Infectious Diseases and Gene Expression in Insects
- Protein Hydrolysis and Bioactive Peptides
- Additive Manufacturing and 3D Printing Technologies
- Cancer Cells and Metastasis
- Lung Cancer Treatments and Mutations
- 3D Printing in Biomedical Research
- MicroRNA in disease regulation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Radiation Dose and Imaging
- Cardiovascular Disease and Adiposity
Baylor College of Medicine
2019-2023
Michael E. DeBakey VA Medical Center
2023
Dan L Duncan Comprehensive Cancer Center
2021
Texas A&M University
2015-2016
Abstract Adipose tissue resident B cells account for more than 20% of stromal within visceral adipose tissues; however, their functions in the niche are poorly elucidated. Here we report that miR-150 modulates function by controlling activation and interactions with other immune cells. miR-150KO mice displayed exacerbated obesity-associated inflammation systemic insulin resistance, which is recapitulated adoptive transfer cells, but not purified immunoglobulin, into obese null mice. Using...
Abstract Purpose: We report the results of a phase II, randomized, window-of-opportunity trial neoadjuvant durvalumab versus plus tremelimumab followed by surgery in patients with resectable malignant pleural mesothelioma (MPM; NCT02592551). Patients and Methods: The primary objective was alteration intratumoral CD8/regulatory T cell (Treg) ratio after combination immune checkpoint blockade (ICB) therapy. Secondary exploratory objectives included other changes tumor microenvironment,...
Tissue Engineering of cartilage has been hampered by the inability engineered tissue to express native levels type II collagen in vitro. Inadequate are, part, due a failure recapitulate physiological environment culture. In this study, we primary rabbit chondrocytes secreted reporter, Gaussia Luciferase, driven promoter, and applied Design Experiments approach assess chondrogenic differentiation micronutrient-supplemented medium. Using Response Surface Model, 240 combinations micronutrients...
Tissue engineered hyaline cartilage is plagued by poor mechanical properties largely due to inadequate type II collagen expression. Of note, commonly used defined chondrogenic media lack 14 vitamins and minerals, some of which are implicated in chondrogenesis. Type promoter-driven Gaussia luciferase was transfected into ATDC5 cells create a cell with secreted-reporter. The reporter were an aggregate-based culture model develop high-throughput analytic platform. This platform assess the...
Abstract Although the majority of patients with advanced lung adenocarcinoma (LUAD) are eligible to receive immune checkpoint blockade, approximately 80% these tumors resistant this therapeutic approach. Insights at single-cell level into mechanisms that drive LUAD tumorigenesis and relationship histologic heterogeneity response blockade could help identify biomarkers potential combinational approaches improve immunotherapy efficacy. Here, we used a genetically engineered mouse model...
ABSTRACT Tissue Engineering of cartilage has been hampered by the inability engineered tissue to express native levels type II collagen in vitro . Inadequate are, part, due a failure recapitulate physiological environment culture. In this study, we primary rabbit chondrocytes secreted reporter, Gaussia Luciferase, driven promoter, and applied Design Experiments approach assess chondrogenic differentiation micronutrient-supplemented medium. Using Response Surface Model, 240 combinations...
<div>AbstractPurpose:<p>We report the results of a phase II, randomized, window-of-opportunity trial neoadjuvant durvalumab versus plus tremelimumab followed by surgery in patients with resectable malignant pleural mesothelioma (MPM; NCT02592551).</p>Patients and Methods:<p>The primary objective was alteration intratumoral CD8/regulatory T cell (Treg) ratio after combination immune checkpoint blockade (ICB) therapy. Secondary exploratory objectives included other...
Abstract Approximately 20,000 patients per year are diagnosed with esophageal adenocarcinoma (EAC) and malignant pleural mesothelioma (MPM); fewer than 20% survive 5 years. Effective therapeutic strategies limited although receive a combination of chemotherapeutics. These tumors harbor thousands mutations that contribute to tumor development. Downstream oncogenic driving mutations, altered mitochondria promote resistance apoptosis. Dynamic Bcl-2 homology-3 profiling (DBP) is functional assay...
Abstract Tissue engineered hyaline cartilage is plagued by poor mechanical properties largely due to inadequate type II collagen expression. Of note, commonly used defined chondrogenic media lack 14 vitamins and minerals, some of which are implicated in chondrogenesis. Type promoter-driven Gaussia luciferase was transfected into ATDC5 cells create a cell with secreted-reporter. The reporter were an aggregate-based culture model develop high-throughput analytic platform. This platform assess...
Compelling evidence demonstrated that adipose‐tissue‐resident macrophages (ATMs) are critical educators in adipose tissue niche by regulating adipocyte functions. ATMs obese objects primarily display a classical activation status with pro‐inflammatory features (M1), which is major shift from lean tissues exhibit mainly anti‐inflammatory profiles (M2). As the cell compartment stroma, exert profound regulatory effects secreting large amount of molecules upon environmental cues, including...
<div>Abstract<p>Although the majority of patients with advanced lung adenocarcinoma (LUAD) are eligible to receive immune checkpoint blockade, approximately 80% these tumors resistant this therapeutic approach. Insights at single-cell level into mechanisms that drive LUAD tumorigenesis and relationship histologic heterogeneity response blockade could help identify biomarkers potential combinational approaches improve immunotherapy efficacy. Here, we used a genetically engineered...
Supplementary Data from Therapeutic Targeting of Macrophage Plasticity Remodels the Tumor-Immune Microenvironment
<div>Abstract<p>Although the majority of patients with advanced lung adenocarcinoma (LUAD) are eligible to receive immune checkpoint blockade, approximately 80% these tumors resistant this therapeutic approach. Insights at single-cell level into mechanisms that drive LUAD tumorigenesis and relationship histologic heterogeneity response blockade could help identify biomarkers potential combinational approaches improve immunotherapy efficacy. Here, we used a genetically engineered...
Supplementary Data from Therapeutic Targeting of Macrophage Plasticity Remodels the Tumor-Immune Microenvironment
<p>Supplementary Figure 4. Frequencies of other immune and stromal cell compositions before after ICB.</p>
<p>Supplementary Figure 9. Alteration of naïve T (Tnaive) and stem cell-like memory (Tscm) cells in PBMCs BMMCs.</p>
<div>AbstractPurpose:<p>We report the results of a phase II, randomized, window-of-opportunity trial neoadjuvant durvalumab versus plus tremelimumab followed by surgery in patients with resectable malignant pleural mesothelioma (MPM; NCT02592551).</p>Patients and Methods:<p>The primary objective was alteration intratumoral CD8/regulatory T cell (Treg) ratio after combination immune checkpoint blockade (ICB) therapy. Secondary exploratory objectives included other...
<p>Supplementary Figure 4. Frequencies of other immune and stromal cell compositions before after ICB.</p>