A5085891018- Cancer-related molecular mechanisms research
- CRISPR and Genetic Engineering
- RNA Interference and Gene Delivery
- RNA and protein synthesis mechanisms
- RNA regulation and disease
- Virus-based gene therapy research
- RNA Research and Splicing
- Influenza Virus Research Studies
- Viral Infectious Diseases and Gene Expression in Insects
- Immune Cell Function and Interaction
- Medicinal Plants and Bioactive Compounds
- Immune cells in cancer
- RNA modifications and cancer
- Plant Virus Research Studies
- Ferroptosis and cancer prognosis
- Flavonoids in Medical Research
- Immune Response and Inflammation
- Phytochemistry and Biological Activities
- interferon and immune responses
National Cancer Center
2019-2024
Hallym University
2016-2023
Interferons (IFNs) are a crucial component in the innate immune response. Especially IFN-β signaling operates most cell types and plays key role first line of defense upon pathogen intrusion. The induction should be tightly controlled, because its hyperactivation can lead to tissue damage or autoimmune diseases. Activation promoter needs Interferon Regulatory Factor 3 (IRF3), together with Nuclear kappa-light-chain-enhancer activated B cells (NF-κB) Activator Protein 1 (AP-1). Here we report...
Elucidation of the interplay between viruses and host cells is crucial for taming to benefit human health. Cancer therapy using adenovirus, called oncolytic virotherapy, a promising treatment option but not robust in all patients. In addition, inefficient replication adenovirus mouse hampered development an vivo model preclinical evaluation therapeutically engineered adenovirus. nc886 non-coding RNA that suppresses Protein Kinase R (PKR), antiviral protein. this study, we have found greatly...
The polysaccharide component of Angelica gigas induces immuno-stimulatory effects on innate immune cells. However, it is unclear whether A. gigas' adjuvant activity the system can elicit anti-cancer responses.A water-soluble was prepared. How this ISAg modulated activation cells such as dendritic (DCs) examined. ISAg-induced cytotoxic via natural killer (NK) and NKT also tested using a tumor-bearing mouse model.ISAg treatment induced nitric oxide (NO) production cytokine gene expression...
DNA-reactive compounds are harnessed for cancer chemotherapy. Their genotoxic effects considered to be the main mechanism cytotoxicity date. Because this preferentially affects actively proliferating cells, it is postulated that specific cells. Nonetheless, they do harm normal quiescent suggesting there other cytotoxic mechanisms uncovered. By employing doxorubicin as a representative compound, we have discovered involves cellular noncoding RNA (ncRNA) nc886 and protein kinase R (PKR)...
nc886 is a regulatory non-coding RNA (ncRNA) whose expression frequently silenced in malignancies. In the case of esophageal squamous cell carcinoma (ESCC), silencing associated with shorter survival patients, suggesting nc886's tumor suppressor role ESCC. However, this observation has not been complemented by an in-detail study about impact on gene and cellular phenotypes. Here we have shown that inhibits AKT, key protein renowned pro-survival pathway cancer. nc886-silenced cells (nc886-...
Although it has been previously reported that Rhus verniciflua Stokes (RVS) possesses in vitro anti-inflammatory activity, the precise vivo mechanisms of RVS extracts and a main active component called fisetin have not well elucidated. In this study, using newly developed protocols, we prepared urushiol-free but fisetin-enriched investigated their effects on vascular immune system. We found water-soluble fractions detoxified with flavonoid can inhibit lipopolysaccharide-induced production...
Recombinant adenovirus (rAdV) vector is the most promising vehicle to deliver an exogenous gene into target cells and preferred for therapy. Exogenous expression from rAdV often too inefficient induce phenotypic changes amount of administered must be very high achieve a therapeutic dose. However, it hampered because dose likely cytotoxicity by activating immune responses. nc886, 102-nucleotide non-coding RNA that transcribed polymerase III, acts as suppressor facilitator AdV entry nucleus....
Influenza viruses cause severe endemic respiratory infections in both humans and animals worldwide. The emergence of drug-resistant viral strains requires the development new influenza therapeutics. Tabamide A (TA0), a phenolic compound isolated from tobacco leaves, is known to have antiviral activity. We investigated whether synthetic TA0 its derivatives exhibit anti-influenza virus Analysis structure-activity relationship revealed that two hydroxyl groups double bond between C7 C8 are...