A5009172624- RNA regulation and disease
- Cancer-related molecular mechanisms research
- Antioxidant Activity and Oxidative Stress
- Skin Protection and Aging
- Inflammasome and immune disorders
- Genomics, phytochemicals, and oxidative stress
- MicroRNA in disease regulation
- Antimicrobial Peptides and Activities
- Extracellular vesicles in disease
- RNA Research and Splicing
- Telomeres, Telomerase, and Senescence
Kolon Life Science (South Korea)
2019-2021
Lactic acid bacteria (LAB), a probiotic, provide various health benefits. We recently isolated new Lactobacillus paracasei strain with strong anti-inflammatory effects under lipopolysaccharide-induced conditions and proposed mode of action—augmenting the endoplasmic reticulum stress pathway for functions in host cells. The beneficial L. strains on skin have been described; however, paracasei-derived extracellular vesicles (LpEVs) are poorly understood. Herein, we investigated whether LpEVs...
Continuous exposure to ultraviolet B (UVB) can cause photodamage of the skin. This be inhibited by overexpression non-coding RNA, nc886, via protein kinase RNA-activated (PKR) pathway. The study aims identify how UVB inhibits nc886 expression, and it also seeks determine whether substances that control expression influence UV-induced inflammation, mechanisms involved. results suggest irradiation accelerates methylation gene, therefore, reducing its expression. induces activation PKR, which...
Functional studies of organisms and human models have revealed that epigenetic changes can significantly impact the process aging. Non-coding RNA (ncRNA), one regulators, plays an important role in modifying expression mRNAs their proteins. It mediate phenotype cells. has been reported nc886 (=vtRNA2-1 or pre-miR-886), a long ncRNA, suppress tumor formation photo-damages keratinocytes caused by UVB. The aim this study was to determine replicative senescence fibroblasts whether substances...