A5100608883- Food Quality and Safety Studies
- Plant Pathogens and Fungal Diseases
- Fungal Biology and Applications
- Genomics and Phylogenetic Studies
- Plant tissue culture and regeneration
- Peptidase Inhibition and Analysis
- Marine and coastal ecosystems
- Glioma Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Diverse Approaches in Healthcare and Education Studies
- Lymphoma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Physics of Superconductivity and Magnetism
- Cancer Cells and Metastasis
- Cancer-related gene regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Genetic Neurodegenerative Diseases
- Educational Systems and Policies
- Korean Urban and Social Studies
- Forest Insect Ecology and Management
- Natural product bioactivities and synthesis
- Epigenetics and DNA Methylation
- Plant and Fungal Species Descriptions
- Chronic Lymphocytic Leukemia Research
- Mycorrhizal Fungi and Plant Interactions
National Cancer Center
2016-2025
Chungnam National University
2016-2025
Emory University
2016-2025
Hallym University
2001-2025
National Institute of Environmental Research
2019-2024
Ewha Womans University
2000-2024
Brock University
2011-2024
Catholic University of Korea
2000-2024
Massachusetts General Hospital
2015-2024
Harvard University
2015-2024
We present the first Korean individual genome sequence (SJK) and analysis results. The diploid of a male was sequenced to 28.95-fold redundancy using Illumina paired-end sequencing method. SJK covered 99.9% NCBI human reference genome. identified 420,083 novel single nucleotide polymorphisms (SNPs) that are not in dbSNP database. Despite close similarity, significant differences were observed between Chinese (YH), only other Asian available, SJK: (1) 39.87% (1,371,239 out 3,439,107) SNPs...
A comprehensive genetics-based precision medicine strategy to selectively and permanently inactivate only mutant, not normal allele, could benefit many dominantly inherited disorders. Here, we demonstrate the power of our novel inactivating mutant allele using haplotype-specific CRISPR/Cas9 target sites in Huntington's disease (HD), a late-onset neurodegenerative disorder due toxic dominant gain-of-function CAG expansion mutation. Focusing on improving specificity, combined extensive...
Epimedium L. is a phylogenetically and economically important genus in the family Berberidaceae. We here sequenced complete chloroplast (cp) genomes of four species using Illumina sequencing technology via combination de novo reference-guided assembly, which was also first comprehensive cp genome analysis on combining sequence E. koreanum previously reported. The five exhibited typical quadripartite circular structure that rather conserved genomic synteny gene order. However, these presented...
Abstract Cytoplasmic chloroplast (cp) genomes and nuclear ribosomal DNA (nR) are the primary sequences used to understand plant diversity evolution. We introduce a high-throughput method simultaneously obtain complete cp nR using Illumina platform whole-genome sequence. applied 30 rice specimens belonging nine Oryza species. Concurrent phylogenomic analysis of several same AA genome species provides insight into evolution domestication cultivated rice, clarifying three ambiguous but...
The B-type Raf kinase (BRAF) protein is a serine/threonine that has an important role in cellular proliferation, differentiation, and programmed cell death. BRAF gene been recently found to be mutated human carcinomas, predominantly malignant melanoma. aim of this study was investigate the frequency mutation papillary thyroid carcinoma (PTC) Koreans through direct DNA sequencing polymerase chain reaction (PCR)- amplified exon 15 with clinicopathological features. Seventy paraffin-embedded...
We report complete sequences of chloroplast (cp) genome and 45S nuclear ribosomal DNA (45S nrDNA) for 11 Panax ginseng cultivars. have obtained cp nrDNA, the representative barcoding target cytoplasm genome, respectively, based on low coverage NGS sequence each cultivar. The genomes sizes ranged from 156,241 to 156,425 bp major size variation was derived differences in copy number tandem repeats ycf1 gene intergenic regions rps16-trnUUG rpl32-trnUAG. nrDNA unit were 11,091 bp, representing a...
Summary Panax ginseng C. A. Meyer, reputed as the king of medicinal herbs, has slow growth, long generation time, low seed production and complicated genome structure that hamper its study. Here, we unveil genomic architecture tetraploid P. by de novo assembly, representing 2.98 Gbp with 59 352 annotated genes. Resequencing data indicated diploid species diverged in association global warming Southern Asia, two North American evolved via intercontinental migrations. Two whole duplications (...
We report the chloroplast (cp) genome sequence of tartary buckwheat (Fagopyrum tataricum) obtained by next-generation sequencing technology and compared this with previously reported common (F. esculentum ssp. ancestrale) cp genome. The F. tataricum has a total length 159,272 bp, which is 327 bp shorter than gene content, order, orientation are similar to those buckwheat, but some structural variation at tandem palindromic repeat frequencies junction areas. A seven InDels (around 100 bp)...
Recent studies demonstrated that chitinase 3-like-1 (Chi3l1) binds to and signals via IL-13Rα2. However, the mechanism IL-13Rα2 uses mediate effects of Chi3l1 has not been defined. Here, we demonstrate membrane protein, TMEM219, is a binding partner using yeast two-hybrid, co-immunoprecipitation, co-localization bimolecular fluorescence complementation assays. Furthermore, anisotropy nanodisc assays revealed direct physical interaction between TMEM219 IL-13Rα2-Chi3l1 complexes. Null...
ABSTRACT Huntington’s disease (HD), due to expansion of a CAG repeat in HTT , is representative growing number disorders involving somatically unstable short tandem repeats. We find that overlapping and distinct genetic modifiers clinical landmarks somatic blood DNA reveal an underlying complexity cell-type specificity the mismatch repair-related processes influence timing. Differential capture non-DNA-repair gene by multiple measures cognitive motor dysfunction argues additionally for...
BACKGROUND: Although cell therapy has emerged as a promising approach to promote neovascularization, its effects are mostly limited capillaries. To generate larger or stable vessels, layering of mural cells such smooth muscle (SMCs) pericytes is required. Recently, direct reprogramming approaches have been developed for generating SMCs. However, reprogrammed SMCs lack genuine features contractile SMCs, native SMC phenotype; thus, their therapeutic and vessel-forming potential in vivo was not...
Abstract Background Elucidating the molecular mechanisms by which tumors become resistant to Herceptin is critical for treatment of Her2-overexpressed metastatic breast cancer. Methods To further understand resistance at level, we used comparative proteome approaches analyze two human cancer cell lines; Her2-positive SK-BR-3 cells and its Herceptin-resistant (SK-BR-3 HR) cells. Results Heat-shock protein 27 (HSP27) expression was shown be upregulated in HR Suppression HSP27 specific siRNA...
Levan, a polysaccharide that can be produced by both plants and microorganisms, is sugar polymer composed of fructose, with beta-2,6 linkages. Here, we have attempted to assess the possible use levan Zymomonas mobilis as cosmeceutical ingredient. In service this goal, assessed host levan's properties, including its moisturizing effects, cell cytotoxicity, proliferation anti-inflammation effects. Levan exhibited effect was almost exactly same evidenced hyaluronic acid, well similar in human...