A5088738470- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Meningioma and schwannoma management
- Lung Cancer Research Studies
- MicroRNA in disease regulation
- RNA Research and Splicing
- Medical Imaging Techniques and Applications
- Histone Deacetylase Inhibitors Research
- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Blood properties and coagulation
- Extracellular vesicles in disease
- Head and Neck Surgical Oncology
- MRI in cancer diagnosis
- CNS Lymphoma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Photoacoustic and Ultrasonic Imaging
- Cancer, Stress, Anesthesia, and Immune Response
- Minimally Invasive Surgical Techniques
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrospinal fluid and hydrocephalus
- Neuroblastoma Research and Treatments
- Sarcoma Diagnosis and Treatment
- Autophagy in Disease and Therapy
National Cancer Center
2016-2025
Chungnam National University
2022-2025
Ajou University
2025
Cancer Hospital of Chinese Academy of Medical Sciences
2023
National Cancer Center
2016-2022
Chungnam National University Hospital
2022
Cancer Clinic
2019
The goal of this study was to evaluate the therapeutic impact resection metastatic brain tumor cells infiltrating adjacent parenchyma.Between July 2001 and February 2007, 94 patients (67 males 27 females, with a mean age 55.0 +/-12.0 years) underwent single metastasis, followed by systemic chemotherapy or without radiotherapy. In 43 tumors located in noneloquent areas, authors performed microscopic total resections (MTRs) that included parenchyma, they pathologically confirmed during surgery...
Abstract The interplay between glioblastoma stem cells (GSCs) and tumor-associated macrophages (TAMs) promotes progression of multiforme (GBM). However, the detailed molecular mechanisms underlying relationship these two cell types remain unclear. Here, we demonstrate that ARS2 (arsenite-resistance protein 2), a zinc finger is essential for early mammalian development, plays critical roles in GSC maintenance M2-like TAM polarization. directly activates its novel transcriptional target MGLL ,...
Abstract Diffuse infiltration is the main reason for therapeutic resistance and recurrence in glioblastoma (GBM). However, potential targeted therapies GBM stem-like cell (GSC) which responsible invasion are limited. Herein, we report Insulin-like Growth Factor-Binding Protein 5 (IGFBP5) a ligand Receptor tyrosine kinase like Orphan 1 (ROR1), as promising target GSC invasion. Using GSC-derived brain tumor model, GSCs were characterized into invasive or non-invasive subtypes, RNA sequencing...
Surgical spillage has been one of the causative factors for development leptomeningeal seeding (LMS) after resection brain metastases. In this paper, authors' goal was to define related LMS and evaluate difference according tumor location.The authors retrospectively analyzed 242 patients who had undergone The investigated included location with proximity CSF pathway (that is, contacting, involved with, or separated from pathway), method resection, use Cavitron Ultrasonic Aspirator (CUSA).A...
ObjectiveThe aim of this report is to provide accurate nationwide epidemiologic data on primary brain and central nervous system (CNS) tumors in Republic Korea.In 2010, we had reported first diagnosed 2005.In report, updated the by analyzing CNS 2010 using from national cancer incidence database. MethodsData were collected Korean Central Cancer Registry.Crude age-standardized rates calculated terms gender, age, histological type. ResultsA total 10,004 patients with included study.Brain...
Background This report aims to provide accurate nationwide epidemiologic data on primary brain and central nervous system (CNS) tumors in the Republic of Korea.We updated by analyzing CNS diagnosed 2013 using from national cancer incidence database. MethodsData were collected Korean Central Cancer Registry.Crude age-standardized rates calculated terms gender, age, histological type. ResultsA total 11,827 patients with 2013.Brain occurred females more often than males (female:male,...
Necrosis is a hallmark of glioblastoma (GBM) and responsible for poor prognosis resistance to conventional therapies. However, the molecular mechanisms underlying necrotic microenvironment-induced malignancy GBM have not been elucidated. Here, we report that transglutaminase 2 (TGM2) upregulated in perinecrotic region triggered mesenchymal (MES) transdifferentiation glioma stem cells (GSC) by regulating master transcription factors (TF), such as C/EBPβ, TAZ, STAT3. TGM2 expression was...
Radiation-induced autophagy has been shown to play two different roles, in malignant glioma (MG) cells, cytocidal or cytoprotective. However, neither the role of radiation-induced for cell death nor existence autophagy-induced apoptosis, a well-known cell-death pathway after irradiation, verified yet.We observed both temporal and dose-dependent response patterns apoptosis radiation MG lines. Additionally, we investigated through knockdown autophagy-related proteins.Autophagic activity...
Leptomeningeal carcinomatosis (LMC) is frequently associated with hydrocephalus, which quickly devastates the performance of patient. Cerebrospinal fluid (CSF) shunt a widely accepted treatment choice, but clinical outcomes in patients LMC are not well studied. This study aimed to examine efficacy CSF LMC. Seventy confirmed by cytology or magnetic resonance imaging (MRI) underwent ventriculoperitoneal (VP) lumboperitoneal (LP) surgery. We retrospectively analyzed characteristics patients,...
Glioblastoma (GBM) has a poor prognosis after standard treatment. Recently, metformin been shown to have an antitumor effect on glioma cells. We performed the first randomized prospective phase II clinical trial investigate efficacy and safety of in patients with recurrent or refractory GBM treated low-dose temozolomide.Included were randomly assigned control group [placebo plus temozolomide (50 mg/m2, daily)] experimental [metformin (1000 mg, 1500 2000 mg per day during 1st, 2nd, 3rd week...
There is inconsistency among the perioperative management strategies currently used for chronic subdural hematoma (cSDH). Moreover, postoperative complications such as acute intracranial bleeding and cSDH recurrence affect clinical outcome of surgery. This study evaluated risk factors associated with identified an effective strategy patients.A retrospective patients who underwent bur hole craniostomy between 2008 2012 was performed.A consecutive series 303 (234 males 69 females; mean age...
When distant metastases are discovered, it is important to determine receptor profiles of these lesions through histologic examination. However, brain metastasis sites difficult reach be routinely biopsied. The purpose this study was expression estrogen (ER), progesterone (PR), and human epidermal growth factor 2 (HER2) in breast cancer (BCBM) the existence discordance between primary metastasis. A total 37 patients who underwent craniotomies for metastatic tumors arising from at National...
Abstract Glioblastoma is the most common type of malignant primary brain tumor and displays highly aggressive heterogeneous phenotypes. The transcription factor STAT3 has been reported to play a key role in glioblastoma malignancy. Thus, discovering targets functional downstream networks regulated by that govern pathogenesis may lead improved treatment strategies. In this study, we identified poly(A)-specific ribonuclease (PARN), modulator RNA metabolism, activates EGFR–STAT3 signaling...
Background/Objectives: To compare the outcomes of single-port assessment laparoscopic surgery (SPALS) and single-site robotic (SSRS) for benign gynecological diseases. Methods: The clinical data 367 patients who underwent gynecologic at Sejong Chungnam National University Hospital from October 2020 to December 2023 were analyzed retrospectively. Of these patients, 197 received SPALS while 170 SSRS. group comprise 87 hysterectomies, 107 adnexal surgeries (44 cystectomies, 63 adnexectomies) 1...
Leptomeningeal metastasis (LM) is a devastating complication of cancer that difficult to treat. Thus, early diagnosis essential for LM patients. However, cerebrospinal fluid (CSF) cytology has low sensitivity, and imaging approaches are ineffective. We explored targeted CSF metabolic profiling discriminate among other conditions affecting the central nervous system (CNS). quantitatively measured amino acids, biogenic amines, hexoses, acylcarnitines (AC), cholesteryl esters (CE), glycerides,...
Background/Objectives: To compare the outcomes of single-port access laparoscopic surgery (SPALS) and single-site robotic (SSRS) for benign gynecological diseases, we retrospectively analyzed clinical data from 367 patients who underwent gynecologic at Sejong Chungnam National University Hospital October 2020 to December 2023. Methods: Of these patients, 197 SPALS, whereas 170 SSRS. The SPALS group comprised 87 hysterectomy; 107, adnexal (cystectomy: 44, adnexectomy: 63); 1 myomectomy. SSRS...
Abstract Hyaluronic acid (HA) binds to cell-surface receptors such as CD44, and seems be involved in cell adhesion, motility, tumor progression brain. To identify gene expression changes that are initiated by HA, we explored human cytokine arrays U87MG glioma cells identified osteopontin, a secreted matrix protein, transcriptional target of HA. Interestingly, osteopontin was induced HA lacking functional PTEN, suppressor (U87MG, U251MG, U373MG), but not wild-type (wt)-PTEN-harboring (LN18...
<title>Abstract</title> Current treatment strategies for medulloblastoma remain ineffective due to extensive tumor heterogeneity. In this study, we performed integrated multi-omic characterization improve the conventional molecular classification of medulloblastoma, leading identification seven refined distinct subtypes. The SHH group was reclassified into two subgroups, SHHα and SHHβ, while 4 divided three G4α, G4β, G4γ. Group subtypes exhibit neuronal differentiation trajectories: granular...
This study aimed to compare kyphotic changes and postoperative complications between laminectomy laminoplasty for spinal cord tumors. We retrospectively included 110 patients who underwent tumor resection at the Ajou University Medical Center, Korea, January 1994 March 2022 laminoplasty. A total of 59 51 laminoplasty, respectively. The groups had similar demographic characteristics. Tumor locations were classified as cervical, thoracic, lumbar lesions compared. measured preoperative...
Purpose The purpose of this study was to investigate the feasibility and survival benefits combined treatment with radiotherapy adjuvant temozolomide (TMZ) in a Korean sample. Materials Methods A total 750 patients histologically confirmed glioblastoma multiforme, who received concurrent chemoradiotherapy TMZ (CCRT) from January 2006 until June 2011, were analyzed retrospectively. Results After first operation, gross resection (GTR), subtotal (STR), partial (PR), biopsy alone achieved 388...