Fulvio D’Angelo
A5025088765- Glioma Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Phagocytosis and Immune Regulation
- Chromatin Remodeling and Cancer
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Neuroblastoma Research and Treatments
- Single-cell and spatial transcriptomics
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Neurofibromatosis and Schwannoma Cases
- Pancreatic and Hepatic Oncology Research
- Bioinformatics and Genomic Networks
- MicroRNA in disease regulation
- Protein Degradation and Inhibitors
- RNA modifications and cancer
- Microtubule and mitosis dynamics
- Cancer Research and Treatments
- 14-3-3 protein interactions
- Cancer-related molecular mechanisms research
- Ubiquitin and proteasome pathways
- Cancer Mechanisms and Therapy
- Cancer, Hypoxia, and Metabolism
- Mitochondrial Function and Pathology
- Gene expression and cancer classification
University of Miami
2023-2025
Istituto Nazionale di Fisica Nucleare, Sezione di Bologna
2023-2025
Cancer Genetics (United States)
2018-2024
Columbia University Irving Medical Center
2017-2024
Sylvester Comprehensive Cancer Center
2023-2024
Neurological Surgery
2023-2024
University of Bologna
2023-2024
Columbia University
2019-2022
National Center on Addiction and Substance Abuse at Columbia University
2021-2022
Biogem
2013-2021
We present a proteogenomic study of 108 human papilloma virus (HPV)-negative head and neck squamous cell carcinomas (HNSCCs). Proteomic analysis systematically catalogs HNSCC-associated proteins phosphosites, prioritizes copy number drivers, highlights an oncogenic role for RNA processing genes. investigation mutual exclusivity between FAT1 truncating mutations 11q13.3 amplifications reveals dysregulated actin dynamics as common functional consequence. Phosphoproteomics characterizes two...
<ns4:p>Biotechnological advances in sequencing have led to an explosion of publicly available data via large international consortia such as <ns4:ext-link xmlns:ns3="http://www.w3.org/1999/xlink" ext-link-type="uri" ns3:href="http://cancergenome.nih.gov/">The Cancer Genome Atlas (TCGA)</ns4:ext-link>, ns3:href="http://www.encodeproject.org/">The Encyclopedia DNA Elements (ENCODE)</ns4:ext-link>, and ns3:href="http://www.roadmapepigenomics.org/">The NIH Roadmap Epigenomics Mapping Consortium...
<ns4:p>Biotechnological advances in sequencing have led to an explosion of publicly available data via large international consortia such as <ns4:ext-link xmlns:ns3="http://www.w3.org/1999/xlink" ext-link-type="uri" ns3:href="http://cancergenome.nih.gov/">The Cancer Genome Atlas (TCGA)</ns4:ext-link>, ns3:href="https://www.encodeproject.org/">The Encyclopedia DNA Elements (ENCODE)</ns4:ext-link>, and ns3:href="http://www.roadmapepigenomics.org/">The NIH Roadmap Epigenomics Mapping Consortium...
Despite producing a panoply of potential cancer-specific targets, the proteogenomic characterization human tumors has yet to demonstrate value for precision cancer medicine. Integrative multi-omics using machine-learning network identified master kinases responsible effecting phenotypic hallmarks functional glioblastoma subtypes. In subtype-matched patient-derived models, we validated PKCδ and DNA-PK as glycolytic/plurimetabolic proliferative/progenitor subtypes, respectively, qualified...
We present results over an 11-year Solar cycle of cosmic antiprotons based on <a:math xmlns:a="http://www.w3.org/1998/Math/MathML" display="inline"><a:mn>1.1</a:mn><a:mo>×</a:mo><a:msup><a:mn>10</a:mn><a:mn>6</a:mn></a:msup></a:math> events in the rigidity range from 1.00 to 41.9 GV. The <c:math xmlns:c="http://www.w3.org/1998/Math/MathML" display="inline"><c:mover accent="true"><c:mi>p</c:mi><c:mo stretchy="false">¯</c:mo></c:mover></c:math> fluxes exhibit distinct properties. magnitude...
Abstract Tumor adaptation or selection is thought to underlie therapy resistance in glioma. To investigate longitudinal epigenetic evolution of gliomas response therapeutic pressure, we performed an epigenomic analysis 132 matched initial and recurrent tumors from patients with IDH-wildtype (IDHwt) IDH-mutant (IDHmut) IDHwt showed a stable epigenome over time relatively low levels global methylation. The IDHmut high genome-wide DNA methylation that was progressively reduced similar those...
Sampling restrictions have hindered the comprehensive study of invasive non-enhancing (NE) high-grade glioma (HGG) cell populations driving tumor progression. Here, we present an integrated multi-omic analysis spatially matched molecular and multi-parametric magnetic resonance imaging (MRI) profiling across 313 multi-regional biopsies, including 111 from NE, 68 HGG patients. Whole exome RNA sequencing uncover unique genomic alterations to unresectable NE tumor, subclonal events, which inform...
Precision measurements by the Alpha Magnetic Spectrometer (AMS) on International Space Station of deuteron (<a:math xmlns:a="http://www.w3.org/1998/Math/MathML" display="inline"><a:mrow><a:mi>D</a:mi></a:mrow></a:math>) flux are presented. The based <c:math xmlns:c="http://www.w3.org/1998/Math/MathML" display="inline"><c:mrow><c:mn>21</c:mn><c:mo>×</c:mo><c:msup><c:mrow><c:mn>10</c:mn></c:mrow><c:mrow><c:mn>6</c:mn></c:mrow></c:msup></c:mrow></c:math> <e:math...
We report the properties of precision time structures cosmic nuclei He, Li, Be, B, C, N, and O fluxes over an 11-year solar cycle from May 2011 to November 2022 in rigidity range 1.92 60.3 GV. The show similar but not identical variations with amplitudes decreasing increasing rigidity. In particular, below 3.64 GV B fluxes, 2.15 are significantly less affected by modulation than He flux. observe that these differences linearly correlated spectral indices fluxes. This shows, a...
Abstract Epidemiologic and experimental studies have associated changes of blood glucose homeostasis to Bisphenol A (BPA) exposure. We took a toxicogenomic approach investigate the mechanisms low-dose (1 × 10 −9 M) BPA toxicity in ex vivo cultures primary murine pancreatic islets hepatocytes. Twenty-nine inhibited genes were identified none exposed Although their expression was slightly altered, impaired cellular level, as whole, resulted specific phenotypic changes. Damage mitochondrial...
ABSTRACT Background Single-cell RNA sequencing is the reference technique for characterizing heterogeneity of tumor microenvironment. The composition various cell types making up microenvironment can significantly affect way in which immune system activates cancer rejection mechanisms. Understanding cross-talk signals between cells and fundamental importance identification immuno-oncology therapeutic targets. Results We present a novel method, single-cell Tumor–Host Interaction tool (scTHI),...
<title>Abstract</title> Current treatment strategies for medulloblastoma remain ineffective due to extensive tumor heterogeneity. In this study, we performed integrated multi-omic characterization improve the conventional molecular classification of medulloblastoma, leading identification seven refined distinct subtypes. The SHH group was reclassified into two subgroups, SHHα and SHHβ, while 4 divided three G4α, G4β, G4γ. Group subtypes exhibit neuronal differentiation trajectories: granular...
We present the precision measurements of 11 years daily cosmic positron fluxes in rigidity range from 1.00 to 41.9 GV based on 3.4×10^{6} positrons collected with Alpha Magnetic Spectrometer (AMS) aboard International Space Station. The show distinctly different time variations electron at short and long timescales. A hysteresis between is observed a significance greater than 5σ rigidities below 8.5 GV. On contrary, proton similar variation. Remarkably, we found that are modulated more for 7...
Epidemiological and experimental data highlighted the thyroid-disrupting activity of bisphenol A (BPA). Although pivotal to identify mechanisms toxicity, direct low-dose BPA effects on thyrocytes have not been assessed. Here, we report results microarray experiments revealing that transcriptome reacts dynamically exposure, adapting changes in gene expression exposure duration. The response involves many genes, enriching specific pathways biological functions mainly cell death/proliferation...
Background and objective Glioblastoma (GBM) is one of the most aggressive lethal human cancers. Intra-tumoral genetic heterogeneity poses a significant challenge for treatment. Biopsy invasive, which motivates development non-invasive, MRI-based machine learning (ML) models to quantify intra-tumoral each patient. This capability holds great promise enabling better therapeutic selection improve patient outcome. Methods We proposed novel Weakly Supervised Ordinal Support Vector Machine...
The progressive and physiological decline in ovarian function depends on the rate of follicular loss by atresia, contributing to reduction reserve. Genetics environmental factors play important roles senescence onset dysfunctions such as diminished A better understanding mechanisms underlying aging their regulation genetic is needed evaluate reserve predict fertility potential identification more accurate less invasive markers. We report transcriptomic data (i) implicating novel (e.g. EIF2...
Abstract In vitro Omics analysis (i.e. transcriptome) is suggested to predict in vivo toxicity and adverse effects humans, although the causal link between high-throughput data not easily established. Indeed, chemical-organism interaction can involve processes, such as adaptation, established cell cultures. Starting from this consideration we investigate transcriptomic response of immortalized thyrocytes ethylenthiourea chlorpyrifos. revealed specific common genes/mechanisms toxicity,...
Tumor heterogeneity underlies resistance and disease progression in glioblastoma (GBM), tumors most commonly recur adjacent to the surgical resection margins contrast non-enhancing (NE) regions. To date, no targeted therapies have meaningfully altered overall patient survival up-front setting. The aim of this study was characterize intratumoral recurrent GBM using bulk samples from primary taken contrast-enhancing (EN) NE regions.Whole exome RNA sequencing were performed on matched multiple...
As the clinical failure of glioblastoma treatment is attributed by multiple components, including myelin-associated infiltration, assessment molecular mechanisms underlying such process and identification infiltrating cells have been primary objectives in research. Here, we adopted radiogenomic analysis to screen for functionally relevant genes that orchestrate glioma cell infiltration through myelin promote aggressiveness. The receptor Nogo ligand (NgR1) was selected as top candidate...