A5022530414- Glioma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- Advanced MRI Techniques and Applications
- Medical Imaging Techniques and Applications
- Ferroptosis and cancer prognosis
- Lanthanide and Transition Metal Complexes
Barrow Neurological Institute
2023-2024
The University of Texas MD Anderson Cancer Center
2024
Medical College of Wisconsin
2024
Mayo Clinic in Florida
2024
WinnMed
2024
Rhode Island Hospital
2024
Dignity Health
2023
Sampling restrictions have hindered the comprehensive study of invasive non-enhancing (NE) high-grade glioma (HGG) cell populations driving tumor progression. Here, we present an integrated multi-omic analysis spatially matched molecular and multi-parametric magnetic resonance imaging (MRI) profiling across 313 multi-regional biopsies, including 111 from NE, 68 HGG patients. Whole exome RNA sequencing uncover unique genomic alterations to unresectable NE tumor, subclonal events, which inform...
Relative cerebral blood volume (rCBV) obtained from dynamic susceptibility contrast (DSC) MRI is widely used to distinguish high grade glioma recurrence post treatment radiation effects (PTRE). Application of rCBV thresholds yield maps between regional tumor burden and PTRE, a biomarker termed the fractional (FTB). FTB generally measured using conventional double-dose, single-echo DSC-MRI protocols; recently, single-dose, dual-echo protocol was clinically validated by direct comparison...
DSC-MR imaging can be used to generate fractional tumor burden (FTB) maps via application of relative CBV thresholds spatially differentiate glioblastoma recurrence from posttreatment radiation effects (PTRE). Image-localized histopathology was previously validate FTB derived a reference protocol by using preload, moderate flip angle (MFA, 60°), and postprocessing leakage correction. Recently, with low (LFA, 30°) no preload shown provide leakage-corrected (rCBV) equivalent the protocol. This...
Single-echo pulse sequences are commonly employed for DSC-MRI. The multi-echo spin and gradient echo (SAGE) sequence can be useful in multi-contrast multi-scale imaging of morphologic functional features brain tumor vasculature. goal this study is to establish harmonized SAGE analysis protocol across primary MRI vendors facilitate multi-site clinical trials. In work, we present initial results reproducibility repeatability phantom, healthy volunteers high-grade glioma patients.
Early differentiation of tumor recurrence from post treatment radiation effects (PTRE) in glioblastoma patients would improve patient management. The purpose this study is to identify the optimal standardized relative cerebral blood volume (sRCBV) threshold for generating fractional burden (FTB) maps derived new consensus protocol, single-dose, low-flip angle data. To establish threshold, data was compared well-validated, double-dose, moderate-flip In summary, with optimized approach yielded...
Reliable differentiation of tumor recurrence and treatment effects in glioblastoma patients is still a prevailing challenge. The purpose this study to identify the optimal threshold for generating fractional burden (FTB) maps derived from single-dose, dual-echo based standardized relative cerebral blood volume measurements. To establish threshold, data was compared well-validated, double-dose single echo FTB map. In summary, with optimized approach yielded that strongly agreed reference...
Abstract INTRODUCTION Differentiation of glioblastoma recurrence from post treatment radiation effects (PTRE) would improve patient management. Dynamic susceptibility contrast (DSC) MRI can be used to generate fractional tumor burden (FTB) maps, via application regional cerebral blood volume (RCBV) thresholds, spatially differentiate PTRE. FTB maps derived a DSC-MRI protocol that includes agent preload in addition the bolus injection and moderate-flip angle (MFA) been histologically...
Abstract High grade glioma (HGG) represents a group of devastating diseases with dismal prognosis. Surgical resection the contrast enhancing (CE) region HGG remains mainstay treatment, but recurrence inevitably arises from unresected non-contrast (NE) region, surgically inaccessible due to cancer cell invasion into healthy brain tissue. Due its critical role in recurrence, understanding NE is central improvement clinical outcomes. We reveal biological characteristics this through image...