A5100337048- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Gastric Cancer Management and Outcomes
- Meningioma and schwannoma management
- Medical Imaging Techniques and Applications
- Cancer Genomics and Diagnostics
- Metastasis and carcinoma case studies
- Advanced biosensing and bioanalysis techniques
- Lung Cancer Treatments and Mutations
- Esophageal Cancer Research and Treatment
- Neuroblastoma Research and Treatments
- Ferroptosis and cancer prognosis
- CNS Lymphoma Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- RNA Interference and Gene Delivery
- Advanced Glycation End Products research
- Palliative Care and End-of-Life Issues
- Advanced Breast Cancer Therapies
- Neurofibromatosis and Schwannoma Cases
- Vascular Malformations Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Birth, Development, and Health
- Radiation Therapy and Dosimetry
- Advanced Radiotherapy Techniques
Xijing Hospital
2024-2025
The University of Texas MD Anderson Cancer Center
2015-2025
Zhengzhou University
2024-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2025
Air Force Medical University
2024-2025
Southern Medical University
2011-2025
Henan Cancer Hospital
2024-2025
First People's Hospital of Yunnan Province
2025
Guangdong Provincial People's Hospital
2025
Guangdong Academy of Medical Sciences
2025
Abstract Background Glioblastoma (GBM) exhibits profound intratumoral genetic heterogeneity. Each tumor comprises multiple genetically distinct clonal populations with different therapeutic sensitivities. This has implications for targeted therapy and informed paradigms. Contrast-enhanced (CE)-MRI conventional sampling techniques have failed to resolve this heterogeneity, particularly nonenhancing populations. study explores the feasibility of using multiparametric MRI texture analysis...
Background Genetic profiling represents the future of neuro-oncology but suffers from inadequate biopsies in heterogeneous tumors like Glioblastoma (GBM). Contrast-enhanced MRI (CE-MRI) targets enhancing core (ENH) yields adequate tumor only ~60% cases. Further, CE-MRI poorly localizes infiltrative within surrounding non-enhancing parenchyma, or brain-around-tumor (BAT), despite importance characterizing this segment, which universally recurs. In study, we use multiple texture analysis and...
We investigated differences in radiation-induced grade 3+ lymphopenia (G3+L), defined as an absolute lymphocyte count (ALC) nadir of <500 cells/µL, after proton therapy (PT) or X-ray (photon) (XRT) for patients with glioblastoma (GBM).
Abstract Background To determine if proton radiotherapy (PT), compared to intensity-modulated (IMRT), delayed time cognitive failure in patients with newly diagnosed glioblastoma (GBM). Methods Eligible were randomized unblinded PT vs IMRT. The primary endpoint was failure. Secondary endpoints included overall survival (OS), intracranial progression-free (PFS), toxicity, and patient-reported outcomes (PROs). Results A total of 90 enrolled 67 evaluable median follow-up 48.7 months (range...
Cardiac fibrosis plays a critical role in the progression of various forms heart disease, significantly increasing risk sudden cardiac death. However, currently, there are no therapeutic strategies available to prevent onset fibrosis. Here, biomimetic ATP-responsive nanozymes based on genetically engineered cell membranes adapted specifically recognize activated fibroblasts (CFs) for treatment By fusing anti-FAP CAR membrane zeolitic imidazole frameworks-90 (zif-90) cores loaded with...
Abstract Background Radiomic analysis of quantitative features extracted from segmented medical images can be used for predictive modeling prognosis in brain tumor patients. Manual segmentation the components is time-consuming and poses significant reproducibility issues. We compare prediction overall survival (OS) recurrent high-grade glioma(HGG) patients undergoing immunotherapy, using deep learning (DL) classification networks along with radiomic signatures derived manual convolutional...
Though challenging, maximal safe resection of insular gliomas enhances overall and progression-free survival deters malignant transformation. Previously published reports have shown that surgery can be performed with low morbidity. The authors previously described a Berger-Sanai zone classification system for gliomas. Using subsequent dataset, they undertook this study to validate predictability extent (EOR) in patients gliomas.The population included adults who had undergone WHO Grade II,...
BACKGROUND: Low-grade glioma (LGG) patients have increased life expectancy, so interest is high in the treatments that maximize cognition and quality of life. OBJECTIVE: To examine presurgical baseline cognitive deficits a case series LGG determine effects surgical resection with awake mapping. METHODS: We retrospectively assessed neurological deficits, subjective concerns from patient or caregiver, at postsurgery for 22 newly diagnosed who underwent neuropsychological evaluation magnetic...
CDK4/6-dependent cell-cycle regulation is disrupted in most glioblastomas. This study assesses the central nervous system (CNS) pharmacokinetics and tumor pharmacodynamics of ribociclib, a highly selective CDK4/6 inhibitor, patients with recurrent glioblastoma.
OBJECTIVE Maximal safe resection is a primary objective in the management of gliomas. Despite this objective, surgeons and referring physicians may, on basis radiological studies alone, assume glioma to be unresectable. Because imaging studies, including functional MRI, may not localize brain functions (such as language) with high fidelity, simplistic approach exclude some patients from what could resection. Intraoperative direct electrical stimulation (DES) allows for accurate localization...
BACKGROUNDA patient-derived organoid (PDO) platform may serve as a promising tool for translational cancer research. In this study, we evaluated PDO's ability to predict clinical response gastrointestinal (GI) cancers.METHODSWe generated PDOs from primary and metastatic lesions of patients with GI cancers, including pancreatic ductal adenocarcinoma, colorectal cholangiocarcinoma. We compared PDO the observed donor same treatments.RESULTSWe report an approximately 80% concordance rate between...
Small interfering RNAs (siRNAs) are short, double-stranded that use the endogenous RNAi pathway to mediate gene silencing. Phosphorylation facilitates loading of a siRNA into Ago2 complex and subsequent cleavage target mRNA. In this study, 2', 3' seco nucleoside modifications, which contain an acylic ribose ring commonly called unlocked nucleic acids (UNAs), were evaluated at all positions along guide strand targeting apolipoprotein B (ApoB). UNA modifications 1, 2 3 detrimental activity....
Objective To characterize co-deletion of chromosome 1p/19q and IDH1/2 mutation in Chinese brain tumor patients to assess their associations with clinical features. Methods In a series 528 gliomas, pathological radiological materials were reviewed. Pathological constituents subsets, incidences gliomas by regions sides the analyzed. Results Overall, 1p 19q was detected 339 FISH method while sequence determined 280 patients. Gliomas frontal, temporal insular origin had significantly different...
BACKGROUND: The role of radiotherapy after surgery for myxopapillary ependymoma (MPE) is unclear. OBJECTIVE: To review long-term outcomes surgery, with or without radiation, spinal MPE. METHODS: Fifty-one patients MPE treated from 1968 to 2007 were included. Associations between clinical variables and overall survival (OS), progression-free (PFS), local control (LC) tested Cox regression analysis. RESULTS: median age at diagnosis was 35 years (range, 8-63 years). Twenty (39%) had alone, 30...
Palliative care has been associated with improved survival and quality of life, lower rate end-of-life health utilization cost. We examined trends in palliative older pancreatic cancer patients.Pancreatic patients without consults were identified using the Surveillance, Epidemiology, End Results (SEER)-Medicare linked database between 2000 2009. Trend use was studied. Emergency room/intensive unit (ICU) costs last 30 days life compared both groups propensity score-matched (PSM) analysis.Of...
Abstract Glioblastoma is the most aggressive type of primary adult brain tumour. The median survival patients with glioblastoma remains approximately 15 months, and 5-year rate &lt;10%. Current treatment options are limited, standard care has remained relatively constant since 2011. Over last decade, a range different regimens have been investigated very limited success. Tumour recurrence almost inevitable current strategies, as tumours highly heterogeneous invasive. Additionally,...
Brain metastases in esophageal adenocarcinoma (EAC) patients are associated with poor prognosis and remain understudied. We performed multi-omics analysis whole-genome sequencing single-cell spatial transcriptomics on the brain matched primary tumors. Our identified ERBB2 as a recurrent oncogene EAC metastases, 9 out of 10 cases harboring amplifications. Single-cell multi-region revealed that alterations, occur early during disease progression monoclonal seeding. Although median survival our...