A5066408894- Management of metastatic bone disease
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Glioma Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Pain Mechanisms and Treatments
- Advanced Radiotherapy Techniques
- Neurofibromatosis and Schwannoma Cases
- Meningioma and schwannoma management
- Oral and Maxillofacial Pathology
- Brain Metastases and Treatment
- Medical Imaging and Analysis
- Medical Imaging Techniques and Applications
- Cancer Treatment and Pharmacology
- Vascular Malformations Diagnosis and Treatment
- Spinal Hematomas and Complications
- Cancer Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Cervical and Thoracic Myelopathy
- Migraine and Headache Studies
- Trigeminal Neuralgia and Treatments
- Adrenal and Paraganglionic Tumors
- Bone health and treatments
- Intraoperative Neuromonitoring and Anesthetic Effects
The University of Texas MD Anderson Cancer Center
2016-2025
Neurological Surgery
2017-2024
Stony Brook University
2022
Kanazawa University
2022
The Maria Sklodowska-Curie National Research Institute of Oncology
2021
Scripps MD Anderson Cancer Center
2017-2021
Medtronic (Switzerland)
2021
Hofstra University
2021
Northwell Health
2021
Huazhong University of Science and Technology
2021
Neuropathic pain encompasses a diverse array of clinical entities affecting 7-10% the population, which is challenging to adequately treat. Several promising therapeutics derived from molecular discoveries in animal models neuropathic have failed translate following unsuccessful trials suggesting possibility important cellular-level and differences between animals humans. Establishing extent potential laboratory humans, through direct study human tissues and/or cells, likely facilitating...
Peripheral neuropathy is dose limiting in paclitaxel cancer chemotherapy and can result both acute pain during treatment chronic persistent survivors. The hypothesis tested was that produces these adverse effects at least part by sensitizing transient receptor potential vanilloid subtype 1 (TRPV1) through Toll-like 4 (TLR4) signaling. data show paclitaxel-induced behavioral hypersensitivity prevented reversed spinal administration of a TRPV1 antagonist. number + neurons increased the dorsal...
Chemotherapy-induced peripheral neuropathy (CIPN) is a common adverse effect experienced by cancer patients receiving treatment with paclitaxel. The voltage-gated sodium channel 1.7 (Na v 1.7) plays an important role in multiple preclinical models of neuropathic pain and inherited human phenotypes, its gene expression increased dorsal root ganglia (DRGs) paclitaxel-treated rats. Hence, the potential change function Na protein DRGs from male rats paclitaxel-related CIPN female humans...
Here, it is shown that paclitaxel-induced neuropathy associated with the development of spontaneous activity (SA) and hyperexcitability in dorsal root ganglion (DRG) neurons paralleled by increased expression low-voltage-activated calcium channels (T-type; Cav3.2). The percentage DRG showing SA overall mean rate were significantly higher at day 7 rats receiving paclitaxel treatment than vehicle. Cav3.2 was L4-L6 spinal cord segments paclitaxel-treated rats, localized to small calcitonin...
Neuropathic pain is a leading cause of high-impact pain, often disabling and poorly managed by current therapeutics. Here we focused on unique group neuropathic patients undergoing thoracic vertebrectomy where the dorsal root ganglia removed as part surgery allowing for molecular characterization identification mechanistic drivers independently preclinical models. Our goal was to quantify whole transcriptome RNA abundances using RNA-seq in pain-associated human from these patients,...
Abstract SARS-CoV-2 has created a global crisis. COVID-19, the disease caused by virus, is characterized pneumonia, respiratory distress, and hypercoagulation can be fatal. An early sign of infection loss smell, taste, chemesthesis—loss chemical sensation. Other neurological effects have been described, but not explained. It now apparent that many these (for instance joint pain headache) persist for at least months after infection, suggesting sensory neuronal involvement in persistent...
This study describes the implementation of a multimodal, multidisciplinary, evidence-based ERAS program in oncologic spine surgery, identifies and measures several relevant postoperative recovery outcomes, demonstrates feasibility potential benefit improving analgesia decreasing opioid consumption. The underscores importance defining capturing meaningful, patient-specific, patient-reported constant evaluation monitoring group's compliance with program. represents steppingstone for...
OBJECTIVE The objective of this study was to compare fractionation schemes and outcomes patients with renal cell carcinoma (RCC) treated in institutional prospective spinal stereotactic radiosurgery (SSRS) trials who did not previously undergo radiation treatment at the site SSRS. METHODS Patients enrolled 2 separate protocols SSRS between 2002 2011 were included. A secondary analysis performed on nonirradiated RCC metastases either single-fraction (SF) or multifraction (MF) RESULTS 47 sites...
Narrative Review. The management of spinal tumors requires a multi-disciplinary approach including surgery, radiation, and systemic therapy. Surgical approaches typically require posterior segmental instrumentation to maintain long-term stability. Carbon fiber reinforced pedicle screws (CFRP) are increasingly used in the oncologic setting due reductions both imaging artifacts radiotherapy perturbations compared titanium implants. We performed review literature highlight advantages future...
OBJECT High-grade malignant spinal cord compression is commonly managed with a combination of surgery aimed at removing the epidural tumor, followed by stereotactic radiosurgery (SSRS) local tumor control. The authors here introduce use laser interstitial thermotherapy (SLITT) as an alternative to prior SSRS. METHODS Patients high degree due radioresistant tumors were selected for study. Visual analog scale (VAS) scores pain and quality life obtained before within 30 60 days after treatment....
Graphene possesses unique electrical, physical, and chemical properties that may offer significant potential as a bioscaffold for neuronal regeneration after spinal cord injury. The purpose of this investigation was to establish the in vitro biocompatibility pristine graphene interface with primary rat cortical neurons.Graphene films were prepared by vapor deposition on copper foil catalytic substrate subsequent apposition bare Permanox plastic polymer dishes. Rat cell culture grown...
BACKGROUND: Although surgery followed by radiation effectively treats metastatic epidural compression, the ideal surgical approach should enable fast recovery and rapid institution of systemic therapy directed at primary tumor. OBJECTIVE: To assess spinal laser interstitial thermotherapy (SLITT) as an alternative to monitored in real time thermal magnetic resonance (MR) images. METHODS: Patients referred for metastasis without motor deficits underwent MR-guided SLITT, stereotactic...
OBJECTIVE The authors investigated the outcomes following spine stereotactic radiosurgery (SSRS) for patients with oligometastatic disease of spine. METHODS study was a secondary analysis 38 209 enrolled in 2 separate institutional Phase I/II prospective protocols and treated SSRS between 2002 2011. Of these patients, 33 (87%) were solitary metastasis, no other history metastatic disease. prescribed to 24 Gy 1 fraction (8%), 18 (18%), 16 (11%), 27 3 fractions (53%), 30 5 or 20 (3%)....
Carbon-fiber reinforced polyetheretherketone (CFRP)-based spinal implants are an alternative to titanium, offering less image artifact as their metallic counterparts while maintaining similar biomechanical and biocompatibility properties. Its use in the management of tumors has been reported, however perceived advantages related improved imaging quality, radiation treatment planning, detection tumor recurrence have not fully assessed.We performed a retrospective review medical records...
INTRODUCTION: Chordomas are locally aggressive neoplasms of the axial skeleton with recurrence rates approaching 40%. Moreover, recurrent chordomas nearly impossible to eradicate—highlighting an unmet clinical need. METHODS: Using replicating oncolytic adenovirus Delta-24-RGD, we investigate efficacy chordoma treatment using in vitro approaches, ex vivo bone scaffolds, and murine models. Additionally, explore underlying mechanism OV cytotoxicity, immunogenic cell death, Brachyury modulation,...
RNA sequencing studies on human dorsal root ganglion (hDRG) from patients suffering neuropathic pain show upregulation of OSM, linking this IL-6 family cytokine to disorders. In mice, however, OSM signaling causes itch behaviors through a direct effect its cognate receptor expressed uniquely by pruriceptive sensory neurons. We hypothesized that an expansion in function OSM-OSM (OSMR) disorders humans could be explained species differences expression and signaling. Our situ hybridization...
Renal cell carcinoma (RCC) frequently metastasizes to the spine, and prognosis can be quite variable. Surgical removal of tumor with spinal reconstruction has been a mainstay palliative treatment. The ability predict is valuable when determining role magnitude surgical intervention in cancer patients. To better identify factors affecting survival patients undergoing surgery for metastasis from RCC, authors undertook retrospective analysis large patient cohort at tertiary care center.Relevant...