A5022682132- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Brain Metastases and Treatment
- Neurofibromatosis and Schwannoma Cases
- Immune cells in cancer
- Head and Neck Surgical Oncology
- Vascular Malformations Diagnosis and Treatment
- Nigella sativa pharmacological applications
- Pituitary Gland Disorders and Treatments
- Cytomegalovirus and herpesvirus research
- Intracranial Aneurysms: Treatment and Complications
- Advanced MRI Techniques and Applications
- Extracellular vesicles in disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Lung Cancer Research Studies
- Cerebrospinal fluid and hydrocephalus
- Advanced Neuroimaging Techniques and Applications
- Spine and Intervertebral Disc Pathology
- Immunotherapy and Immune Responses
- Effects of Radiation Exposure
- Nanoplatforms for cancer theranostics
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrovascular and Carotid Artery Diseases
- Management of metastatic bone disease
- Spinal Hematomas and Complications
Bezmiâlem Vakıf Üniversitesi
2015-2024
Biruni University
2024
Ankara Onkoloji Eğitim ve Araştırma Hastanesi
2021
The University of Texas MD Anderson Cancer Center
2008-2020
Kocaeli Üniversitesi
2016
Foundation University
2013
Okmeydanı Eğitim ve Araştırma Hastanesi
2006-2010
Baylor College of Medicine
2009
Ministry of Health
2006-2007
OBJECTIVE To determine the impact of intraoperative magnetic resonance imaging (iMRI) on decision to proceed with additional glioma resection during surgery and maximize extent (EOR). METHODS Patients who underwent craniotomy for high-field iMRI guidance were prospectively evaluated between September 2006 August 2007. Volumetric analysis EOR assessed iMRI, using postcontrast T1-weighted images tumors showing contrast enhancement T2-weighted nonenhancing tumors. RESULTS Forty-six patients...
Local recurrence (LR) of a resected brain metastasis occurs in up to 46% patients. Postoperative whole-brain radiation therapy (WBRT) reduces that incidence. To isolate factors associated with the risk LR after resection, authors only studied patients who did not receive adjuvant radiotherapy.The reviewed data from 570 cases involving had undergone resection previously untreated single at The University Texas M. D. Anderson Cancer Center between 1993 and 2006 without receiving postoperative...
OBJECTIVE To test the hypothesis that differential risks of developing leptomeningeal disease (LMD) exist in patients having a single supratentorial brain metastasis resected via piecemeal or en bloc approach treated with stereotactic radiosurgery (SRS). METHODS Between 1993 and 2006, 827 underwent resection SRS at The University Texas M.D. Anderson Cancer Center. primary outcome was incidence LMD. RESULTS Resection performed 191 351 patients; 285 received SRS. LMD occurred 33 patients, 29...
Cytomegalovirus (CMV) has been ubiquitously detected within high-grade gliomas, but its role in gliomagenesis not fully elicited.Glioblastoma multiforme (GBM) tumors were analyzed by flow cytometry to determine CMV antigen expression various glioma-associated immune populations. The glioma cancer stem cell (gCSC) interleukin (IL)-10 production was determined ELISA. Human monocytes stimulated with recombinant IL-10 and levels of p-STAT3, VEGF (vascular endothelial growth factor), TGF-β, viral...
OBJECT Brain metastases are the most common intracranial neoplasms and on increase. As radiation side effects increasingly better understood, more patients being treated with surgery alone varying outcomes. The authors previously reported that en bloc resection of a single brain metastasis was associated decreased incidences leptomeningeal disease local recurrence compared piecemeal resection. However, is often feared to cause an increased incidence postoperative complications. This study...
Brain metastasis is a devastating complication of systemic malignancy that affects considerable number cancer patients.The appearance brain metastases often considered to be sign poor prognosis; in patients with survival time has been reported the literature.Therefore, treatment these lesions important for quality life, providing local tumour control, preventing death from neurological causes, and improving survival, although potentially only minority patients.Surgical resection cornerstone...
Treatment of tumors metastatic to the brainstem with stereotactic radiosurgery (SRS) has not been widely studied.To identify effects SRS on patients metastases by assessing duration local progression-free survival (LPFS) and overall survival.We retrospectively reviewed clinical data collected from 60 undergoing linear accelerator-based for between August 1994 December 2007. The LPFS were calculated Kaplan-Meier method. Prognostic factors evaluated log-rank test Cox proportional hazards...
Renal cell carcinoma (RCC) frequently metastasizes to the spine, and prognosis can be quite variable. Surgical removal of tumor with spinal reconstruction has been a mainstay palliative treatment. The ability predict is valuable when determining role magnitude surgical intervention in cancer patients. To better identify factors affecting survival patients undergoing surgery for metastasis from RCC, authors undertook retrospective analysis large patient cohort at tertiary care center.Relevant...
Glioblastoma, as an invasive tumor, is one of the most common primary malignant brain tumors. Despite maximum aggressive treatment, patients with glioblastoma have a dismal prognosis. Thymoquinone (TQ) has been found to show anti-cancer effects on different types cancer. There are few in vitro studies effect TQ glial However, molecular mechanism TQ's not fully elucidated. In present study, we aimed investigate genotoxic, apoptotic, and cytotoxic C6 rat glioma cells. cells were analyzed after...
Liquid biopsy can be used to make the diagnosis, screen treatment response, and predict prognosis. Extracellular vesicles (EVs) cell-free DNA (cfDNA) sources are as liquid biomarkers from body fluids such serum, cerebrospinal fluid, urine, mucosa. The purpose of this study was investigate whether EVs cfDNA predictive for diagnosis prognosis in patients with glioma. levels were measured 17 glioma at three different time intervals (before surgery, 10–14 days after recurrence) 7 healthy...
Abstract Melanoma is a common and deadly tumor that upon metastasis to the central nervous system (CNS) has median survival duration of less than 5 months. Activation signal transducer activator transcription 3 (STAT3) been identified as key mediator drives fundamental components melanoma. We hypothesized WP1066, novel inhibitor STAT3 signaling, would enhance antitumor activity cyclophosphamide (CTX) against melanoma, including disease within CNS. The mechanisms efficacy were investigated by...
A 28-year-old woman presented with a rare primary epidural hemangioma without adjacent vertebral involvement manifesting as progressive paraparesis. Magnetic resonance imaging of the thoracic spine showed an lesion at T4-5 space appearing isointense on T1-weighted images enhancement by contrast medium and hyperintense T2-weighted images. The was totally removed microsurgically. Histological examination revealed cavernous hemangioma. She made complete recovery from her symptoms has remained...